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Sylvester Yao Lokpo

University of Health and Allied Sciences

67 publications · 897 citations · ORCID 0000-0002-1628-0735

Diabetes, Cardiovascular Risks, and LipoproteinsMalaria Research and ControlAdipokines, Inflammation, and Metabolic DiseasesMosquito-borne diseases and controlHepatitis B Virus Studies

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Sylvester Yao Lokpo is a public health and biomedical researcher focused on the epidemiology, clinical management, and comorbidities of non-communicable and infectious diseases in Ghana. Lokpo's work frequently investigates metabolic syndrome, diabetes, and dyslipidaemia, while also encompassing studies on HIV, malaria, and hepatitis. Recent research has expanded into predictive modeling using machine learning and the review of environmental toxicology impacts on neurological health.

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What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

  1. New developments in tuberculosis diagnosis and treatment — Breathe, 2022
  2. Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
  3. Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
  4. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
  5. Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
  6. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
  7. Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
  8. Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
  9. Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
  10. Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

How does the longitudinal trajectory of maternal stress and resilience during pregnancy specifically mediate the association between social determinants of health (e.g., socioeconomic status, structural inequality) and infant cognitive or emotional development outcomes?

Why this gap exists: While the retrieved literature confirms associations between socioeconomic disadvantage, maternal stress, and infant neurodevelopment, it does not resolve the specific question of how longitudinal trajectories of maternal stress and resilience mediate these associations, as the studies focus on broad correlations or static measures rather than dynamic mediation pathways.

Sources

  1. Maternal Depression During Pregnancy and the Postnatal Period — JAMA Psychiatry, 2013
  2. Socioeconomic disadvantage, gestational immune activity, and neurodevelopment in early childhood — Proceedings of the National Academy of Sciences, 2017
  3. Disrupted beginnings: Neurodevelopmental outcomes of COVID-19 lockdowns in early childhood (Review). — Experimental and therapeutic medicine, 2026
  4. Pregnancy as a period of risk, adaptation, and resilience for mothers and infants — Development and Psychopathology, 2020
  5. The influence of attachment and relational quality on developmental outcomes across the lifespan: a systematic review and meta-analytic insights (2014-2024). — Frontiers in psychology, 2026
  6. Nutrition as the Foundation of Human Capital: Pathways to Holistic Development. — Maternal & child nutrition, 2026
  7. Chronic stress may disrupt covariant fluctuations of vitamin D and cortisol plasma levels in pregnant sheep during the last trimester: a preliminary report — arXiv preprint, 2019
  8. Resilience and Stress during Pregnancy: A Comprehensive Multidimensional Approach in Maternal and Perinatal Health — The Scientific World JOURNAL, 2021
  9. Maternal Stress During Pregnancy and Infant and Child Outcome — Oxford Handbooks Online, 2014
  10. Maternal Docosahexaenoic Acid Status During Pregnancy and Its Impact on Infant Neurodevelopment — 2020

How does the consumption of plant-based proteins, specifically those high in anti-nutritional factors like phytates and trypsin inhibitors, affect mineral bioavailability and growth outcomes in children relying on these proteins as primary staples?

Why this gap exists: While the retrieved papers confirm that anti-nutritional factors like phytates and trypsin inhibitors reduce mineral bioavailability [0, 2], they focus on general adult health or crop improvement [1, 6] and do not provide direct evidence on the specific growth outcomes in children relying on these proteins as primary staples.

Sources

  1. Plant food anti-nutritional factors and their reduction strategies: an overview — Food Production Processing and Nutrition, 2020
  2. Sustaining Protein Nutrition Through Plant-Based Foods — Frontiers in Nutrition, 2022
  3. Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds — Nutrients, 2020
  4. Faba Bean: An Untapped Source of Quality Plant Proteins and Bioactives — Nutrients, 2022
  5. Nutritional properties and health aspects of pulses and their use in plant‐based yogurt alternatives — Comprehensive Reviews in Food Science and Food Safety, 2021
  6. Grains – a major source of sustainable protein for health — Nutrition Reviews, 2021
  7. Healthy and Resilient Cereals and Pseudo-Cereals for Marginal Agriculture: Molecular Advances for Improving Nutrient Bioavailability — Frontiers in Genetics, 2020
  8. Protein Quality in Perspective: A Review of Protein Quality Metrics and Their Applications — Nutrients, 2022
  9. Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases — Nutrients, 2021
  10. Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits — Frontiers in Nutrition, 2020

How do specific policy interventions aimed at improving female education and labor force participation accelerate the 'maternal mortality transition' in regions currently experiencing high maternal mortality?

Why this gap exists: While the retrieved literature establishes links between female education, political power, and health outcomes (e.g., [3], [6], [9]), no study directly addresses how specific labor or education policy interventions accelerate the 'maternal mortality transition' in high-mortality regions, leaving the mechanism and impact of such specific policies unresolved.

Sources

  1. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 — The Lancet, 2024
  2. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 — The Lancet, 2024
  3. Determinants of female labor force participation: implications for policy in Qatar — Cogent Social Sciences, 2022
  4. Maternal Mortality and Women’s Political Power — Journal of the European Economic Association, 2023
  5. The labor force participation of Indian women before and after widowhood — Demographic Research, 2020
  6. The public health effects of interventions similar to basic income: a scoping review — The Lancet Public Health, 2020
  7. Differential impact of maternal education on under-five mortality in rural and urban India — Health & Place, 2023
  8. Public Health Expenditure and Under-five Mortality in Nigeria: An Overview for Policy Intervention — Open Access Macedonian Journal of Medical Sciences, 2020
  9. Efficacy of companion-integrated childbirth preparation for childbirth fear, self-efficacy, and maternal support in primigravid women in Malawi — BMC Pregnancy and Childbirth, 2020
  10. The contribution of female health to economic development — The Economic Journal, 2020

What is the comparative effectiveness of telemedicine versus traditional in-person care in maintaining essential antenatal coverage and reducing maternal mortality in low-income and middle-income countries during future health system shocks?

Why this gap exists: While abstracts [4], [7], [8], and [9] discuss digital tools and maternity care in low- and middle-income countries, none provide a direct comparative effectiveness analysis of telemedicine versus in-person care regarding maternal mortality during health system shocks, leaving the specific question unresolved.

Sources

  1. COVID-19 and resilience of healthcare systems in ten countries — Nature Medicine, 2022
  2. Community Health Workers Can Provide Psychosocial Support to the People During COVID-19 and Beyond in Low- and Middle- Income Countries — Frontiers in Public Health, 2021
  3. Social Impacts and Responses Related to COVID-19 in Low- and Middle-income Countries — OpenDocs (Institute of Development Studies), 2020
  4. Seizing the moment to rethink health systems — The Lancet Global Health, 2021
  5. Use of mHealth in promoting maternal and child health in “BIMARU” states of India “A health system strengthening strategy”: Systematic literature review — PLOS Digital Health, 2024
  6. Investments for effective functionality of health systems towards Universal Health Coverage in Africa: A scoping review — PLOS Global Public Health, 2022
  7. Infant and young child feeding — OECD eBooks, 2023
  8. Facilitators and barriers to the implementation of a Mobile Health Wallet for pregnancy-related health care: A qualitative study of stakeholders’ perceptions in Madagascar — PLoS ONE, 2020
  9. The impact of digital interventions on health insurance coverage for reproductive, maternal, newborn and child health services utilization in Kakamega, Kenya: a cluster randomized controlled trial — Health Policy and Planning, 2024
  10. Seeking digital maternity healthcare during the pandemic health system shock: a systematic review of women's experiences in low- and middle-income countries — Frontiers in Reproductive Health, 2026

Publications

The role of microplastics exposure in Alzheimer’s and Parkinson’s disease

Discover Applied Sciences · 2026

Metabolic Syndrome With Concomitant Anaemia Among Patients With Type 2 Diabetes Mellitus in the Volta Region of Ghana: A Cross‐Sectional Study

Journal of Nutrition and Metabolism · 2026 · corresponding author

Toxoplasma gondii seropositivity among patients with sickle cell disease: Prevalence and association with blood transfusion history

PLoS ONE · 2026

Predictive models and determinants of mortality among T2DM patients in a tertiary hospital in Ghana, how do machine learning techniques perform?

BMC Endocrine Disorders · 2025 · 8 citations

Identification of hematological biomarkers and assessment of machine learning models for sickle cell anemia severity classification

Journal of sickle cell disease. · 2025 · 2 citations

Prevalence of anaemia and associated factors among patients with type 2 diabetes mellitus in the Ho municipality in Ghana

Ghana Medical Journal · 2025 · 1 citations

Hypothyroidism phenotypes, clinical characteristics, and factors associated with nodular thyroid disease in patients with hypothyroidism in Southern Ghana: a 6-year retrospective study

BMC Endocrine Disorders · 2025 · 1 citations

Hypothyroidism phenotypes, clinical characteristics and factors associated with nodular thyroid disease in patients with hypothyroidism in southern Ghana: A 6-year retrospective study

Research Square · 2025

Demographic, clinical characteristics, polycystic ovarian syndrome phenotypes and predictors of anti-mullerian hormone among women with PCOS at a Fertility Center in Ghana: A 5-year retrospective study

Research Square · 2025

The utility of simple biomarkers of inflammation in the diagnosis of dyslipidaemia among patients with type 2 diabetes mellitus in the Ho municipality: a cross sectional study

Discover Medicine · 2025 · corresponding author

The utility of simple biomarkers of inflammation in the diagnosis of dyslipidaemia among patients with type 2 diabetes mellitus in the Ho Municipality: A cross sectional study

Research Square · 2025

Age and sex-specific analysis of mixed dyslipidaemia among patients with type 2 diabetes mellitus in the Ho municipality: A cross-sectional study

Research Square · 2025

Association between Interleukin-6 Gene Polymorphism (rs1800795 and rs1800796) and Type 2 Diabetes Mellitus in a Ghanaian Population: A Case-Control Study in the Ho Municipality

BioMed Research International · 2024 · corresponding author · 7 citations

Association between asymptomatic Plasmodium falciparum malaria infection, anaemia and mean corpuscular volume of school children in the Volta Region of Ghana

European Journal of Microbiology and Immunology · 2024 · 1 citations

Predictive models and determinants of mortality among T2DM patients in a tertiary hospital in Ghana, how do Machine Learning Techniques perform?

Research Square · 2024

Assessing nursing mothers’ knowledge, perceptions and uptake of Sulphadoxine Pyrimethamine (IPTp-SP) during pregnancy in the Ho Teaching Hospital of the Volta Region of Ghana

PLOS Global Public Health · 2023 · corresponding author · 13 citations

Performance of Body Adiposity Index and Relative Fat Mass in Predicting Bioelectric Impedance Analysis‐Derived Body Fat Percentage: A Cross‐Sectional Study among Patients with Type 2 Diabetes in the Ho Municipality, Ghana

BioMed Research International · 2023 · corresponding author · 11 citations

Predictors of metabolic syndrome and its components in patients with type 2 diabetes: A cross-sectional study in the Ho municipality, Ghana

Scientific African · 2023 · corresponding author · 5 citations

Association between asymptomatic Plasmodium falciparum malaria infection, anemia and mean corpuscular volume of school children in the Volta Region of Ghana

American Journal of Clinical Pathology · 2023 · 1 citations

Metabolic Syndrome and Renal Dysfunction Coexistence and Associated Factors in Patients with Type 2 Diabetes in Ghana: A Cross-Sectional Study

SSRN Electronic Journal · 2023 · corresponding author

Lipoprotein-Associated Phospholipase A2 has Comparable Ability as Anthropometric Indices to Discriminate Cardiovascular Disease Risk: A Cross-Sectional Study.

PubMed · 2023

The pattern of dyslipidaemia and factors associated with elevated levels of non-HDL-cholesterol among patients with type 2 diabetes mellitus in the Ho municipality: A cross sectional study

Heliyon · 2022 · corresponding author · 13 citations

Evaluating the impact of COVID-19 pandemic on complicated malaria admissions and outcomes in the paediatric Ho Teaching Hospital of the Volta Region of Ghana

PLOS Global Public Health · 2022 · 8 citations

Abdominal volume index is a better predictor of visceral fat in patients with type 2 diabetes: a cross-sectional study in Ho municipality, Ghana

Alexandria Journal of Medicine · 2022 · corresponding author · 7 citations

Nexus between constructs of social cognitive theory model and diabetes self-management among Ghanaian diabetic patients: A mediation modelling approach

PLOS Global Public Health · 2022 · 6 citations

Nutritional aberration and related morphological disorders among patients with human immunodeficiency virus infection on combination antiretroviral therapy (cART) in Ghana: A retrospective study

Heliyon · 2022 · 2 citations

Evaluating knowledge of malaria and health seeking behavior among clients attending hospital in the Ho Municipality of the Volta Region of Ghana

Journal of Global Health Science · 2022 · 2 citations

Association between Physical Inactivity and Metabolic Syndrome in South-West Nigeria.

PubMed · 2022 · 1 citations

The Pattern of Dyslipidaemia and Factors Associated With Elevated Non-HDL-Cholesterol Levels Among Patients With Type 2 Diabetes Mellitus in the Ho Municipality: A Cross Sectional Study

SSRN Electronic Journal · 2022 · corresponding author

Epidemiological surveillance and burden of serological infectious markers among adult population of New Juaben Municipality: A 6-year laboratory review from the Eastern Regional Hospital, Ghana

International Journal of Blood Transfusion and Immunohematology · 2022

<scp>HIV</scp> and malaria prevalence among pregnant women with and without pre‐eclampsia at the Atua Government Hospital in Ghana’s eastern region

International Journal of Gynecology & Obstetrics · 2022

Hepatitis B and C infections in HIV-1 patients on combination antiretroviral therapy (cART) in Ghana: implications for immunologic recovery, clinical response to treatment, and hepatotoxicity

Heliyon · 2021 · corresponding author · 16 citations

Factors Influencing Adherence to Tuberculosis Treatment in the Ketu North District of the Volta Region, Ghana

Tuberculosis Research and Treatment · 2021 · 15 citations

Community burden of hypertension and treatment patterns: An in-depth age predictor analysis: (The Rural Community Risk of Non-Communicable Disease Study - Nyive Phase I)

PLoS ONE · 2021 · 8 citations

A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five‐Year Multisite Parallel Population‐Based Analysis vis‐à‐vis the Sentinel Survey

BioMed Research International · 2021 · corresponding author · 6 citations

Eosinophilia in school-going children with plasmodium falciparum and helminth infections in the Volta region of Ghana

Pan African Medical Journal · 2021 · 5 citations

Physician Perception and Diagnosis of Intestinal Parasitic Infections among Patients with Gastrointestinal Symptoms in Ghana

Journal of Parasitology Research · 2021 · 2 citations

Health risk assessment and levels of toxic metals in fishes (Oreochromis noliticus and Clarias anguillaris) from Ankobrah and Pra basins: Impact of illegal mining activities on food safety

Toxicology Reports · 2020 · 209 citations

Viral Suppression and Its Associated Factors in HIV Patients on Highly Active Antiretroviral Therapy (HAART): A Retrospective Study in the Ho Municipality, Ghana

AIDS Research and Treatment · 2020 · corresponding author · 54 citations

Asymptomatic Intestinal Parasitic Infestations among Children Under Five Years in Selected Communities in the Ho Municipality, Ghana

Ethiopian Journal of Health Sciences · 2020 · 16 citations

Comparative assessment of anthropometric and bioimpedence methods for determining adiposity

Heliyon · 2020 · 10 citations

Evaluation of dietary patterns and haematological profile of apparently healthy officers of the Central Prisons in the Ho municipality. A cross sectional study

Scientific African · 2020 · corresponding author · 4 citations

The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana

Journal of Tropical Medicine · 2019 · 35 citations

Prevalence of Polyparasitic Infection Among Primary School Children in the Volta Region of Ghana

Open Forum Infectious Diseases · 2019 · 27 citations

Comparative assessment of methods for determining adiposity and a model for obesity index

bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 1 citations

A comparative study of the epidemiology of Treponemal Infection in the Volta Region of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey

Research Square · 2019

The Epidemiology of Syphilis in the Volta Region of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey

Research Square · 2019

Cardiometabolic Risk Factors among Healthcare Workers: A Cross-Sectional Study at the Sefwi-Wiawso Municipal Hospital, Ghana

BioMed Research International · 2018 · 35 citations

Medication Adherence and its Association with Glycaemic Control, Blood Pressure Control, Glycosuria and Proteinuria Among People Living With Diabetes (PLWD) in the Ho Municipality, Ghana

The Open Public Health Journal · 2018 · 19 citations

The Epidemiology of Human Immunodeficiency Virus (HIV) and Syphilis in Ghana: A Five-Year Single Urban Site Parallel Population-Based Analysis vis-à-vis the Sentinel Survey

Journal of Tropical Medicine · 2018 · 18 citations

Malaria Burden and Trend Among Clients Seeking Healthcare in the Western Region: A 4-Year Retrospective Study at the Sefwi-Wiawso Municipal Hospital, Ghana

The Open Microbiology Journal · 2018 · 10 citations

Renal Dysfunction among Ghanaians Living with Clinically Diagnosed Hypertension in the Asutifi‐South District: A Cross‐Sectional Descriptive Study at the St. Elizabeth Hospital, Hwidiem

International Journal of Hypertension · 2018 · corresponding author · 8 citations

Gaps in Laboratory Quality Management Systems in the Volta Region of Ghana

Asian Journal of Medicine and Health · 2018 · 6 citations

Chronic Kidney Disease among Ghanaian HIV Individuals on HAART in the Ho Municipality: A Single-Center Descriptive Cross-Sectional Study

Asian Journal of Biology · 2018 · 4 citations

Cardio-Metabolic Risk Profile of a Diabetic Population in the Ho Municipality

2018 · 2 citations

Cardiovascular risk markers in type II diabetes and hypertension at the Battor Catholic Hospital, Volta Region of Ghana

Tanzania journal of health research/Tanzania Journal of Health Research · 2018

The Prevalence of Metabolic Syndrome and Its Components among People with Type 2 Diabetes in the Ho Municipality, Ghana: A Cross-Sectional Study

International Journal of Chronic Diseases · 2017 · 67 citations

Quality of Life of People Living with HIV/AIDS in the Ho Municipality, Ghana: A Cross-Sectional Study

AIDS Research and Treatment · 2017 · 59 citations

Sero-prevalence of hepatitis B infection among blood donors in a secondary care hospital, Ghana (2014): a retrospective analysis

BMC Research Notes · 2017 · 46 citations

Sero-prevalence of hepatitis B surface antigen amongst pregnant women attending an antenatal clinic, Volta region, Ghana

Journal of Public Health in Africa · 2017 · corresponding author · 33 citations

Viral Hepatitis Endemicity and Trends among an Asymptomatic Adult Population in Ho: A 5-Year Retrospective Study at the Ho Municipal Hospital, Ghana

Hepatitis Research and Treatment · 2017 · corresponding author · 20 citations

The Burden and Trend of Blood-Borne Pathogens among Asymptomatic Adult Population in Akwatia: A Retrospective Study at the St. Dominic Hospital, Ghana

Journal of Tropical Medicine · 2017 · corresponding author · 17 citations

Maternal Age, Low Birth Weight and Early Neonatal Death in Tertiary Hospital in the Volta Region of Ghana

Open Journal of Pediatrics · 2017 · 8 citations

Association between Anthropometry, Dyslipidaemia and the Ten-Year Relative Risk of Cardiovascular Disease in Ghanaians with Type 2 Diabetes and Hypertension at the Battor Catholic Hospital

OALib · 2017 · 1 citations

Comparative Performance Evaluation of Routine Malaria Diagnosis at Ho Municipal Hospital

Journal of Parasitology Research · 2016 · 18 citations

Quality of Life of People Living with Type 2 Diabetes in Ho, Ghana: A Cross-Sectional Study

American Journal of Biomedical Sciences · 2016 · 7 citations

Physical Activity Pattern and Its Association with Glycaemic and Blood Pressure Control among People Living with Diabetes (PLWD) In The Ho Municipality, Ghana

Ethiopian Journal of Health Sciences · 1970 · 22 citations