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Eric Kyei‐Baafour

University of Ghana

60 publications · 560 citations · ORCID 0000-0001-6423-1885

Malaria Research and ControlMosquito-borne diseases and controlvaccines and immunoinformatics approachesParasites and Host InteractionsComplement system in diseases

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Eric Kyei‐Baafour is an immunologist and infectious disease researcher focused on understanding and measuring naturally acquired immunity to malaria in Ghanaian populations. Kyei‐Baafour investigates immune correlates of protection, antibody responses to specific parasite antigens, and the impact of host genetic factors on disease severity. Additionally, Kyei‐Baafour has contributed to studies on Lassa fever vaccine development, reproductive health in adolescents, and the immunology of co-infections such as hepatitis B and schistosomiasis.

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What is the comparative efficacy and cost-effectiveness of the one-step 75g OGTT versus the two-step (50g GCT followed by 100g OGTT) diagnostic approach in preventing adverse maternal and neonatal outcomes?

Why this gap exists: While Abstract [7] compares diagnostic criteria and Abstract [4] compares 75g and 100g OGTTs, the retrieved evidence lacks direct, comparative studies on the cost-effectiveness and relative efficacy of the one-step versus two-step *approaches* in preventing adverse outcomes, leaving the specific question unresolved.

Sources

  1. Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO Criteria — PLoS ONE, 2016
  2. A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes — New England Journal of Medicine, 2009
  3. Standards of Medical Care in Diabetes—2013 — Diabetes Care, 2012
  4. An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative Review — Diabetes Metabolic Syndrome and Obesity, 2021
  5. Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to detect gestational diabetes mellitus — Frontiers in Endocrinology, 2025
  6. Large language models for generating longitudinal synthetic data in low-risk pregnancy care. — Data in brief, 2026
  7. Effects of physical activity and diet in pregnancy to prevent gestational diabetes: an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation. — Health technology assessment (Winchester, England), 2026
  8. 187-OR: Randomized Clinical Trial of the IADPSG vs. Carpenter Coustan Criteria for Diagnosis of Gestational Diabetes Mellitus — Diabetes, 2020
  9. Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A cross-sectional study. — Diabetes & metabolic syndrome, 2019
  10. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026

To what extent does maternal access to improved water and sanitation facilities mediate the relationship between maternal undernutrition and child developmental outcomes during the first 1,000 days?

Why this gap exists: While the retrieved papers confirm the individual importance of WASH access for child nutrition [0], maternal undernutrition for child development [5, 8], and the critical nature of the first 1,000 days [5], none of the provided abstracts directly analyze the specific mediating role of water and sanitation facilities in the relationship between maternal undernutrition and child developmental outcomes.

Sources

  1. Household water, sanitation, and hygiene access and its impact on nutritional outcomes in children under five: evidence from Pakistan. — BMC public health, 2026
  2. Early childhood development and stunting: Findings from the MAL‐ED birth cohort study in Bangladesh — Maternal and Child Nutrition, 2019
  3. Policy and Structural Drivers of Malnutrition in Afghan Women: Evidence and Interventions. — International journal of women's health, 2026
  4. COVID-19 pandemic and mitigation strategies: implications for maternal and child health and nutrition — American Journal of Clinical Nutrition, 2020
  5. Maternal and child undernutrition 3: what works? Interventions for maternal and child undernutrition and survival — Child: Care, Health and Development, 2008
  6. Nutrition as the Foundation of Human Capital: Pathways to Holistic Development. — Maternal & child nutrition, 2026
  7. The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring. — The British journal of nutrition, 2017
  8. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  9. Prevalence of undernutrition and its associated factors among pregnant women attending antenatal care service in public hospitals in Mogadishu, Somalia. — PloS one, 2026
  10. Concurrent wasting and stunting among under‐five children in Niakhar, Senegal — Maternal & Child Nutrition, 2018

How do specific policy frameworks regarding social protection and food systems in low-income countries moderate the projected increase in child wasting and maternal undernutrition caused by economic shocks like the COVID-19 pandemic?

Why this gap exists: While the retrieved literature confirms the projected increase in child wasting and maternal undernutrition due to COVID-19 disruptions [0] and explores general concepts of food system resilience [2] and social protection [3], no study directly quantifies how specific policy frameworks moderate these projected outcomes, leaving the core interaction unresolved.

Sources

  1. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  2. Biofortification as a sustainable strategy to address micronutrient malnutrition in South Asia. — Journal of health, population, and nutrition, 2025
  3. Resilience of local food systems and links to food security – A review of some important concepts in the context of COVID-19 and other shocks — Food Security, 2020
  4. Resilience and Recovery in the Informal Economy: Social Networks, Social Protection, and Adaptive Strategies Among Post-COVID Workers in Bangladesh. — Public health challenges, 2026
  5. Malnutrition at a Crossroads: The Impact of Pandemic, Climate Change, and War on Tigray’s Children Malnutrition — 2026
  6. Economic Shocks, Inequality and Poverty: The Need for Safety Nets — 1998
  7. Lessons from low-to middle-income countries on the development of child protection systems — The Development of Child Protection Systems and Practice in Low- to Middle-Income Countries, 2025
  8. Drivers of Stunting Reduction in Yogyakarta, Indonesia: A Case Study. — International journal of environmental research and public health, 2022
  9. Inequality, mobility and the financial accumulation process: A computational economic analysis — Journal of Economic Interaction and Coordination (2020), online, 2019
  10. The Role of Agriculture in Ensuring Food Security in Developing Countries: Considerations in the Context of the Problem of Sustainable Food Production — Sustainability, 2020

What is the comparative efficacy of household water treatment interventions versus improved water source infrastructure in reducing stunting among children under five in low- and middle-income countries?

Why this gap exists: While the retrieved literature confirms associations between water quality and child growth (e.g., Abstracts 2, 5, 8), no study directly compares the efficacy of household water treatment interventions against improved water source infrastructure for reducing stunting, leaving the specific comparative question unresolved.

Sources

  1. Determinants of stunting in Indonesian children: evidence from a cross-sectional survey indicate a prominent role for the water, sanitation and hygiene sector in stunting reduction — BMC Public Health, 2016
  2. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  3. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trial — The Lancet Global Health, 2018
  4. Effects of Water Pollution on Human Health and Disease Heterogeneity: A Review — Frontiers in Environmental Science, 2022
  5. Associated factors with malnutrition among children under-5 years old in Somaliland: evidence from Somaliland health and demographic survey of 2020. — BMC public health, 2026
  6. Safe Drinking Water and Its Impact on Children's Growth and Development: A Systematic Review. — International journal of environmental research and public health, 2026
  7. Modelling the impact of dietary diversity on child nutrition in Pakistan: a machine learning analysis with Shapley Additive exPlanations and Boruta interpretability. — Journal of global health, 2026
  8. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis — The Lancet, 2022
  9. Effect of Household Source of Drinking Water on Malnutrition among under Five Children in Ethiopia: Systematic Review and Meta-Analysis — 2026
  10. Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields — Water 2017, 9, 339, 2018

How do specific cultural beliefs regarding 'insufficient milk' in rural South African communities mediate the relationship between maternal dietary diversity and the introduction of prelacteal feeds?

Why this gap exists: While the retrieved papers discuss general breastfeeding barriers in South Africa [8] and cultural influences in other regions like Ethiopia [6] and Malaysia [9], none specifically address the mediation of 'insufficient milk' beliefs on the relationship between maternal dietary diversity and prelacteal feeds in rural South African communities.

Sources

  1. African Political Systems. — American Sociological Review, 1940
  2. Maternal nutrition counselling is associated with reduced stunting prevalence and improved feeding practices in early childhood: a post-program comparison study — Nutrition Journal, 2019
  3. Trends and determinants of early initiation of breastfeeding and exclusive breastfeeding in Ethiopia from 2000 to 2016 — International Breastfeeding Journal, 2019
  4. Marketing of commercial milk formula: a system to capture parents, communities, science, and policy — The Lancet, 2023
  5. Facilitators, barriers, and factors determining the willingness to donate human milk among postpartum mothers in a tertiary women's hospital in Nepal: a cross-sectional study. — International breastfeeding journal, 2026
  6. Assessment of Infant and Young Child Feeding Practices among Mothers Attending Maternal and Child Health Clinic at a Tertiary Hospital, North Karnataka, India - A Cross-sectional Study. — Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine, 2025
  7. Sociocultural and structural influences on infant and young child feeding in pastoralist communities of Afar, Ethiopia: a qualitative phenomenological study. — BMJ open, 2026
  8. Knowledge, attitude, and practice of exclusive breastfeeding among mothers in East Africa: a systematic review — International Breastfeeding Journal, 2020
  9. Facilitators and barriers associated with breastfeeding among mothers attending primary healthcare facilities in Mpumalanga, South Africa. — Frontiers in nutrition, 2023
  10. Assessing the Influence of Cultural Beliefs and Practices on Early Breastfeeding Initiation Rates in Rural Sarawak Communities, Malaysia — Scientific Journal of Pediatrics, 2023

How does the aggressive marketing of breastmilk substitutes in low-income countries specifically modify the effectiveness of workplace breastfeeding interventions on exclusive breastfeeding rates?

Why this gap exists: While the retrieved literature addresses workplace barriers [7] and the negative impact of breastmilk substitute marketing [2, 9] separately, no study directly investigates the interaction effect or modification of workplace intervention effectiveness by aggressive marketing in low-income countries.

Sources

  1. The cost of not breastfeeding: global results from a new tool — Health Policy and Planning, 2019
  2. Breastfeeding indicators trends in Brazil for three decades — Revista de Saúde Pública, 2017
  3. The World Health Organization Code and exclusive breastfeeding in China, India, and Vietnam — Maternal and Child Nutrition, 2018
  4. Breastfeeding: crucially important, but increasingly challenged in a market-driven world — The Lancet, 2023
  5. "People who have money feed formula to their infants": a qualitative study of exclusive breastfeeding barriers and potential interventions in Lao People's Democratic Republic. — BMC public health, 2026
  6. The politics of breastfeeding: a feminist analysis of breastfeeding policies and promotion in Nigeria. — International breastfeeding journal, 2026
  7. Pumps, patriarchy, and profits: the rise of breast pumping and "human milk feeding" and why preserving "breastfeeding" is important. — International breastfeeding journal, 2026
  8. Examining working mothers’ experience of exclusive breastfeeding in Ghana — International Breastfeeding Journal, 2020
  9. Prenatal Hand Expression of Breastmilk to Help Increase Breastfeeding Initiation and Exclusive Breastfeeding Rates — 2022
  10. Assessing Compliance: Violations of WHO Code in Breast Milk Substitute Marketing, Ecuador. — Maternal & child nutrition, 2025

Publications

Reevaluating malaria severity metrics: insights from PfHRP2-derived biomass estimates in Ghanaian children

Malaria Journal · 2026 · 2 citations

Development and qualification of an enzyme-linked immunosorbent assay to detect human serum immunoglobulin G reactive to multiple lineages of Lassa virus nucleoprotein

PLoS ONE · 2026

Immunogenicity of HLA-restricted peptide vaccine candidates delivered by self-assembling protein nanoparticle (SAPN) technology

Vaccine · 2025 · 1 citations

Determination of Salivary Lactoferrin Levels Before and After Non-Surgical Periodontal Treatment in Patients with Aggressive Periodontitis

Postgraduate Medical Journal of Ghana · 2025 · 1 citations

Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults

Frontiers in Immunology · 2025 · 1 citations

Wider antibody breadth against multiple Plasmodium falciparum antigens is associated with reduced risk of malaria in a transmission hotspot in southern Ghana

International Journal of Infectious Diseases · 2025

Regional variations and socioeconomic factors influencing sex hormone profiles in adolescent girls in Ghana

Frontiers in Reproductive Health · 2025 · corresponding author

Immunogenicity of Hla-Restricted Peptide Vaccine Candidates Delivered by Self-Assembling Protein Nanoparticle (Sapn) Technology

SSRN Electronic Journal · 2025

Plasmodium falciparum AMA1 and CSP antigen diversity in parasite isolates from southern Ghana

Frontiers in Cellular and Infection Microbiology · 2024 · 2 citations

Expression patterns of immune checkpoint proteins and <i>Plasmodium falciparum</i>‐induced cytokines in chronic hepatitis B virus‐infected and uninfected individuals: A cross‐sectional study

Health Science Reports · 2024 · 2 citations

Seventh Annual Research Meeting of the Noguchi Memorial Institute for Medical Research: Malaria Control and Elimination

Ghana Medical Journal · 2024 · 2 citations

Host-parasite interaction in severe and uncomplicated malaria infection in ghanaian children

European Journal of Clinical Microbiology & Infectious Diseases · 2024 · 1 citations

Knowledge, perceptions, and management of symptoms of hormonal imbalance among adolescent girls in selected schools in Ghana: a qualitative exploratory study

Frontiers in Reproductive Health · 2024 · 1 citations

Seventh Annual Research Meeting of the Noguchi Memorial Institute for Medical Research: Health Systems Research

Ghana Medical Journal · 2024

Seventh Annual Research Meeting of the Noguchi Memorial Institute for Medical Research: Viral Infections

Ghana Medical Journal · 2024

Ex-vivo evaluation of Plasmodium falciparum-induced cytokine expression in chronic hepatitis B virus-infected and uninfected individuals

Open Research Europe · 2024

Impact of haemoglobinopathies on asymptomatic Plasmodium falciparum infection and naturally acquired immunity among children in Northern Ghana

Frontiers in Hematology · 2023 · 13 citations

Plasmodium falciparum infection and naturally acquired immunity to malaria antigens among Ghanaian children in northern Ghana

Parasite Epidemiology and Control · 2023 · 11 citations

Immunodominant T cell peptides from four candidate malarial antigens as biomarkers of protective immunity against malaria

Vaccine · 2023 · 8 citations

High burden of asymptomatic malaria and anaemia despite high adherence to malaria control measures: a cross-sectional study among pregnant women across two seasons in a malaria-endemic setting in Ghana

Infection · 2023 · 5 citations

High opsonic phagocytosis activity and growth inhibition of merozoites are associated with RON4 antibody levels and protect against febrile malaria in Ghanaian children

Frontiers in Immunology · 2023 · 5 citations

(untitled)

International Journal of Pharmaceutical Sciences and Research · 2023 · 1 citations

Serology reveals micro-differences in Plasmodium falciparum transmission in the Hohoe municipality of Ghana

Frontiers in Parasitology · 2023

Perturbations in the T cell receptor β repertoire during malaria infection in children: A preliminary study

Frontiers in Immunology · 2022 · 6 citations

Immunodominant T Cell Peptides from Four Candidate Malarial Antigens as Biomarkers of Protective Immunity Against Malaria

SSRN Electronic Journal · 2022 · 1 citations

Influence of &alpha;2-Macroglobulin, Anti-Parasite IgM and ABO Blood Group on Rosetting in Plasmodium falciparum Clinical Isolates and Their Associations with Disease Severity in a Ghanaian Population

DOAJ (DOAJ: Directory of Open Access Journals) · 2022

Total Salivary Immunoglobulin A determination before and after Non-surgical periodontal treatment in patients with Aggressive periodontitis

Research Square · 2022 · corresponding author

Total Salivary Immunoglobulin A Determination Before and After Non-Surgical Periodontal Treatment in Patients with Aggressive Periodontitis

Journal of Surgery and Research · 2022 · corresponding author

Suitability of IgG responses to multiple Plasmodium falciparum antigens as markers of transmission intensity and pattern

PLoS ONE · 2021 · 9 citations

Towards large-scale identification of HLA-restricted T cell epitopes from four vaccine candidate antigens in a malaria endemic community in Ghana

Vaccine · 2021 · 8 citations

Ex vivo Sensitivity Profile of Plasmodium falciparum Clinical Isolates to a Panel of Antimalarial Drugs in Ghana 13 Years After National Policy Change

Infection and Drug Resistance · 2021 · 7 citations

Associations of IL13 gene polymorphisms and immune factors with Schistosoma haematobium infection in schoolchildren in four schistosomiasis-endemic communities in Ghana

PLoS neglected tropical diseases · 2021 · 6 citations

Comparative analysis of the ex vivo IFN-gamma responses to CD8+ T cell epitopes within allelic forms of PfAMA1 in subjects with natural exposure to malaria

PLoS ONE · 2021 · 5 citations

Acute Phase Responses Vary Between Children of HbAS and HbAA Genotypes During Plasmodium falciparum Infection

Journal of Inflammation Research · 2021 · 4 citations

Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

The Journal of Infectious Diseases · 2021 · 2 citations

Corrigendum: Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response

Frontiers in Microbiology · 2021 · 1 citations

IgG Responses as markers of malaria transmission and pattern

Figshare · 2021

Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response

Frontiers in Microbiology · 2020 · 58 citations

Prevalence of sickle cell disorders and malaria infection in children aged 1–12 years in the Volta Region, Ghana: a community-based study

Malaria Journal · 2020 · 25 citations

Impact of an Irrigation Dam on the Transmission and Diversity of <i>Plasmodium falciparum</i> in a Seasonal Malaria Transmission Area of Northern Ghana

Journal of Tropical Medicine · 2020 · corresponding author · 20 citations

Microscopic and Submicroscopic Asymptomatic Plasmodium falciparum Infections in Ghanaian Children and Protection against Febrile Malaria

Infection and Immunity · 2020 · 20 citations

Implementation of Antibody Rapid Diagnostic Testing versus Real-Time Reverse Transcription-PCR Sample Pooling in the Screening of COVID-19: a Case of Different Testing Strategies in Africa

mSphere · 2020 · 15 citations

Identification of Plasmodium falciparum circumsporozoite protein-specific CD8+ T cell epitopes in a malaria exposed population

PLoS ONE · 2020 · 11 citations

Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas

Scientific Reports · 2020 · 8 citations

The First Eighty-Four (84) Days of COVID-19 in Africa: Analysis of Incidence and Deaths Associated with COVID-19

SSRN Electronic Journal · 2020

Drug sensitivity of Plasmodium falciparum field isolates to selected antimalarial drugs in Ghana using the in-vitro DAPI assay

2020

The search for a broadly effective multi-epitope malaria vaccine candidate

Faculty of 1000 Research Ltd · 2020

Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana

Scientific Reports · 2019 · 4 citations

The prevalence of submicroscopic Plasmodium falciparum gametocyte carriage and multiplicity of infection in children, pregnant women and adults in a low malaria transmission area in Southern Ghana

Malaria Journal · 2018 · 57 citations

Etiology of Placental Plasmodium falciparum Malaria in African Women

The Journal of Infectious Diseases · 2018 · 19 citations

Elevated Proangiogenic Markers are Associated with Vascular Complications within Ghanaian Sickle Cell Disease Patients

Medical Sciences · 2018 · 15 citations

Effect of IPTp on Plasmodium falciparum antibody levels among pregnant women and their babies in a sub-urban coastal area in Ghana

Malaria Journal · 2017 · 26 citations

Variations in the quality of malaria-specific antibodies with transmission intensity in a seasonal malaria transmission area of Northern Ghana

PLoS ONE · 2017 · 22 citations

Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana

International Journal of Vascular Medicine · 2017 · 7 citations

Seroprevalence of Antibodies against Plasmodium falciparum Sporozoite Antigens as Predictive Disease Transmission Markers in an Area of Ghana with Seasonal Malaria Transmission

PLoS ONE · 2016 · 16 citations

Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana

Journal of Diabetes & Metabolic Disorders · 2016 · 2 citations

Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana

Journal of Diabetes & Metabolic Disorders · 2016

Naturally acquired antibody responses to recombinant Pfs230 and Pfs48/45 transmission blocking vaccine candidates

Journal of Infection · 2015 · 67 citations

Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation

Malaria Journal · 2014 · 37 citations

Fc Gamma Receptor 3B (FCGR3B-c.233C&gt;A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children

The Journal of Infectious Diseases · 2013 · 26 citations