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Harriet Affran Bonful

University of Ghana

55 publications · 458 citations · ORCID 0000-0003-0069-3241

Malaria Research and ControlGlobal Maternal and Child HealthAntibiotic Use and ResistancePharmaceutical Quality and CounterfeitingHIV/AIDS Research and Interventions

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Harriet Affran Bonful is a public health researcher specializing in infectious disease control, pharmacovigilance, and health service delivery in Ghana. Bonful's work focuses heavily on malaria case management, including the evaluation of diagnostic practices, treatment adherence, and community acceptance of interventions. Additionally, Bonful investigates antibiotic stewardship, medication safety, and the use of mobile health technology for disease screening and prevention.

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What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

What is the comparative efficacy of digital or telehealth lactation support versus traditional face-to-face peer support on breastfeeding exclusivity rates during pandemic-related social restrictions?

Why this gap exists: While Abstract [3] confirms the general effectiveness of digital health interventions on breastfeeding practices and Abstract [0] notes the cancellation of face-to-face peer support during the pandemic, the retrieved evidence does not contain a direct comparative study between digital/telehealth lactation support and traditional face-to-face peer support specifically regarding exclusivity rates during social restrictions.

How do specific policy frameworks regarding social protection and food systems in low-income countries moderate the projected increase in child wasting and maternal undernutrition caused by economic shocks like the COVID-19 pandemic?

Why this gap exists: While the retrieved literature confirms the projected increase in child wasting and maternal undernutrition due to COVID-19 disruptions [0] and explores general concepts of food system resilience [2] and social protection [3], no study directly quantifies how specific policy frameworks moderate these projected outcomes, leaving the core interaction unresolved.

Sources

  1. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling studyThe Lancet Global Health, 2020
  2. Biofortification as a sustainable strategy to address micronutrient malnutrition in South Asia.Journal of health, population, and nutrition, 2025
  3. Resilience of local food systems and links to food security – A review of some important concepts in the context of COVID-19 and other shocksFood Security, 2020
  4. Resilience and Recovery in the Informal Economy: Social Networks, Social Protection, and Adaptive Strategies Among Post-COVID Workers in Bangladesh.Public health challenges, 2026
  5. Malnutrition at a Crossroads: The Impact of Pandemic, Climate Change, and War on Tigray’s Children Malnutrition2026
  6. Economic Shocks, Inequality and Poverty: The Need for Safety Nets1998
  7. Lessons from low-to middle-income countries on the development of child protection systemsThe Development of Child Protection Systems and Practice in Low- to Middle-Income Countries, 2025
  8. Drivers of Stunting Reduction in Yogyakarta, Indonesia: A Case Study.International journal of environmental research and public health, 2022
  9. Inequality, mobility and the financial accumulation process: A computational economic analysisJournal of Economic Interaction and Coordination (2020), online, 2019
  10. The Role of Agriculture in Ensuring Food Security in Developing Countries: Considerations in the Context of the Problem of Sustainable Food ProductionSustainability, 2020

What is the comparative efficacy of household water treatment interventions versus improved water source infrastructure in reducing stunting among children under five in low- and middle-income countries?

Why this gap exists: While the retrieved literature confirms associations between water quality and child growth (e.g., Abstracts 2, 5, 8), no study directly compares the efficacy of household water treatment interventions against improved water source infrastructure for reducing stunting, leaving the specific comparative question unresolved.

Sources

  1. Determinants of stunting in Indonesian children: evidence from a cross-sectional survey indicate a prominent role for the water, sanitation and hygiene sector in stunting reductionBMC Public Health, 2016
  2. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling studyThe Lancet Global Health, 2020
  3. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trialThe Lancet Global Health, 2018
  4. Effects of Water Pollution on Human Health and Disease Heterogeneity: A ReviewFrontiers in Environmental Science, 2022
  5. Associated factors with malnutrition among children under-5 years old in Somaliland: evidence from Somaliland health and demographic survey of 2020.BMC public health, 2026
  6. Safe Drinking Water and Its Impact on Children's Growth and Development: A Systematic Review.International journal of environmental research and public health, 2026
  7. Modelling the impact of dietary diversity on child nutrition in Pakistan: a machine learning analysis with Shapley Additive exPlanations and Boruta interpretability.Journal of global health, 2026
  8. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysisThe Lancet, 2022
  9. Effect of Household Source of Drinking Water on Malnutrition among under Five Children in Ethiopia: Systematic Review and Meta-Analysis2026
  10. Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum FieldsWater 2017, 9, 339, 2018

What is the comparative efficacy and cost-effectiveness of the one-step 75g OGTT versus the two-step (50g GCT followed by 100g OGTT) diagnostic approach in preventing adverse maternal and neonatal outcomes?

Why this gap exists: While Abstract [7] compares diagnostic criteria and Abstract [4] compares 75g and 100g OGTTs, the retrieved evidence lacks direct, comparative studies on the cost-effectiveness and relative efficacy of the one-step versus two-step *approaches* in preventing adverse outcomes, leaving the specific question unresolved.

Sources

  1. Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO CriteriaPLoS ONE, 2016
  2. A Multicenter, Randomized Trial of Treatment for Mild Gestational DiabetesNew England Journal of Medicine, 2009
  3. Standards of Medical Care in Diabetes—2013Diabetes Care, 2012
  4. An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative ReviewDiabetes Metabolic Syndrome and Obesity, 2021
  5. Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to detect gestational diabetes mellitusFrontiers in Endocrinology, 2025
  6. Large language models for generating longitudinal synthetic data in low-risk pregnancy care.Data in brief, 2026
  7. Effects of physical activity and diet in pregnancy to prevent gestational diabetes: an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation.Health technology assessment (Winchester, England), 2026
  8. 187-OR: Randomized Clinical Trial of the IADPSG vs. Carpenter Coustan Criteria for Diagnosis of Gestational Diabetes MellitusDiabetes, 2020
  9. Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A cross-sectional study.Diabetes & metabolic syndrome, 2019
  10. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health.International journal of women's health, 2026

What is the comparative effectiveness of telemedicine versus traditional in-person care in maintaining essential antenatal coverage and reducing maternal mortality in low-income and middle-income countries during future health system shocks?

Why this gap exists: While abstracts [4], [7], [8], and [9] discuss digital tools and maternity care in low- and middle-income countries, none provide a direct comparative effectiveness analysis of telemedicine versus in-person care regarding maternal mortality during health system shocks, leaving the specific question unresolved.

Sources

  1. COVID-19 and resilience of healthcare systems in ten countriesNature Medicine, 2022
  2. Community Health Workers Can Provide Psychosocial Support to the People During COVID-19 and Beyond in Low- and Middle- Income CountriesFrontiers in Public Health, 2021
  3. Social Impacts and Responses Related to COVID-19 in Low- and Middle-income CountriesOpenDocs (Institute of Development Studies), 2020
  4. Seizing the moment to rethink health systemsThe Lancet Global Health, 2021
  5. Use of mHealth in promoting maternal and child health in “BIMARU” states of India “A health system strengthening strategy”: Systematic literature reviewPLOS Digital Health, 2024
  6. Investments for effective functionality of health systems towards Universal Health Coverage in Africa: A scoping reviewPLOS Global Public Health, 2022
  7. Infant and young child feedingOECD eBooks, 2023
  8. Facilitators and barriers to the implementation of a Mobile Health Wallet for pregnancy-related health care: A qualitative study of stakeholders’ perceptions in MadagascarPLoS ONE, 2020
  9. The impact of digital interventions on health insurance coverage for reproductive, maternal, newborn and child health services utilization in Kakamega, Kenya: a cluster randomized controlled trialHealth Policy and Planning, 2024
  10. Seeking digital maternity healthcare during the pandemic health system shock: a systematic review of women's experiences in low- and middle-income countriesFrontiers in Reproductive Health, 2026

Publications

Exploring quality of life among elderly persons living with HIV in Accra, Ghana

PLoS ONE · 2025 · corresponding author · 3 citations

Predictors of quality of life of TB/HIV co-infected patients in the Northern region of Ghana

BMC Infectious Diseases · 2024 · corresponding author · 3 citations

Coping strategies among adolescents and young adults living with HIV/AIDS in Accra-Ghana

BMC Public Health · 2023 · corresponding author · 7 citations

Analysis of dog bite surveillance data, Volta Region, Ghana, 2020

Frontiers in Tropical Diseases · 2023 · 6 citations

Coping strategies among adolescents and young adults living with HIV/AIDS in Accra-Ghana

Research Square · 2022 · corresponding author · 2 citations