Yakubu Alhassan

University of Ghana

54 publications · 426 citations · ORCID 0000-0002-0658-3820

Malaria Research and ControlHIV/AIDS Research and InterventionsChild Nutrition and Water AccessMosquito-borne diseases and controlVaccine Coverage and Hesitancy

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Yakubu Alhassan is a public health researcher specializing in epidemiology and health systems analysis, with a strong focus on infectious diseases, maternal and child health, and non-communicable diseases in Ghana and West Africa. Alhassan's work frequently employs large-scale survey data and cohort studies to evaluate treatment outcomes, vaccination coverage, and the impact of public health interventions such as insecticide-treated nets. Recent research has expanded to include COVID-19 vaccine responses, cancer genomics, and the development of data curation tools for infection studies.

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What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

New developments in tuberculosis diagnosis and treatment — Breathe, 2022
Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

What is the comparative efficacy of household water treatment interventions versus improved water source infrastructure in reducing stunting among children under five in low- and middle-income countries?

Why this gap exists: While the retrieved literature confirms associations between water quality and child growth (e.g., Abstracts 2, 5, 8), no study directly compares the efficacy of household water treatment interventions against improved water source infrastructure for reducing stunting, leaving the specific comparative question unresolved.

Sources

Determinants of stunting in Indonesian children: evidence from a cross-sectional survey indicate a prominent role for the water, sanitation and hygiene sector in stunting reduction — BMC Public Health, 2016
Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trial — The Lancet Global Health, 2018
Effects of Water Pollution on Human Health and Disease Heterogeneity: A Review — Frontiers in Environmental Science, 2022
Associated factors with malnutrition among children under-5 years old in Somaliland: evidence from Somaliland health and demographic survey of 2020. — BMC public health, 2026
Safe Drinking Water and Its Impact on Children's Growth and Development: A Systematic Review. — International journal of environmental research and public health, 2026
Modelling the impact of dietary diversity on child nutrition in Pakistan: a machine learning analysis with Shapley Additive exPlanations and Boruta interpretability. — Journal of global health, 2026
Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis — The Lancet, 2022
Effect of Household Source of Drinking Water on Malnutrition among under Five Children in Ethiopia: Systematic Review and Meta-Analysis — 2026
Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields — Water 2017, 9, 339, 2018

How do specific policy frameworks regarding social protection and food systems in low-income countries moderate the projected increase in child wasting and maternal undernutrition caused by economic shocks like the COVID-19 pandemic?

Why this gap exists: While the retrieved literature confirms the projected increase in child wasting and maternal undernutrition due to COVID-19 disruptions [0] and explores general concepts of food system resilience [2] and social protection [3], no study directly quantifies how specific policy frameworks moderate these projected outcomes, leaving the core interaction unresolved.

Sources

Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
Biofortification as a sustainable strategy to address micronutrient malnutrition in South Asia. — Journal of health, population, and nutrition, 2025
Resilience of local food systems and links to food security – A review of some important concepts in the context of COVID-19 and other shocks — Food Security, 2020
Resilience and Recovery in the Informal Economy: Social Networks, Social Protection, and Adaptive Strategies Among Post-COVID Workers in Bangladesh. — Public health challenges, 2026
Malnutrition at a Crossroads: The Impact of Pandemic, Climate Change, and War on Tigray’s Children Malnutrition — 2026
Economic Shocks, Inequality and Poverty: The Need for Safety Nets — 1998
Lessons from low-to middle-income countries on the development of child protection systems — The Development of Child Protection Systems and Practice in Low- to Middle-Income Countries, 2025
Drivers of Stunting Reduction in Yogyakarta, Indonesia: A Case Study. — International journal of environmental research and public health, 2022
Inequality, mobility and the financial accumulation process: A computational economic analysis — Journal of Economic Interaction and Coordination (2020), online, 2019
The Role of Agriculture in Ensuring Food Security in Developing Countries: Considerations in the Context of the Problem of Sustainable Food Production — Sustainability, 2020

What are the specific long-term treatment strategies required to mitigate the risk of developing chronic non-communicable diseases in children born to mothers with gestational diabetes mellitus?

Why this gap exists: While the retrieved literature consistently establishes that maternal gestational diabetes mellitus (GDM) increases the long-term risk of cardiometabolic diseases in offspring [1][2][3], it focuses primarily on pathogenesis and risk association rather than defining specific, evidence-based long-term treatment strategies for the children to mitigate these risks.

Sources

Diagnosis and Classification of Diabetes Mellitus — Diabetes Care, 2010
A Clinical Update on Gestational Diabetes Mellitus — Endocrine Reviews, 2022
Maternal Diabetes and Risk of Early-Onset Cardiovascular Diseases in Offspring. — JAMA cardiology, 2026
Gestational diabetes as an inter-generational cardiometabolic risk factor: spotlight on emerging exerkines. — Cardiovascular diabetology, 2026
Gestational diabetes: from pathogenesis to therapeutic intervention. — Diabetology & metabolic syndrome, 2026
2. Classification and Diagnosis of Diabetes:<i>Standards of Medical Care in Diabetes—2022</i> — Diabetes Care, 2021
Maternal congenital heart disease and risk of child developmental vulnerability in early school age: A population-based cohort study. — PLoS medicine, 2026
Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026
Gestational Diabetes and Obesity: Immediate and Late Sequelae for Offspring. — Children (Basel, Switzerland), 2025
Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications — Diabetes & Metabolism Journal, 2022

How do specific maternal microbiota profiles (gut, oral, or vaginal) during gestation correlate with the development of gestational diabetes mellitus (GDM) and subsequent long-term metabolic health in offspring?

Why this gap exists: While recent reviews [8] confirm GDM alters maternal gut microbiota and neonatal health, and older studies [0] note dysbiosis across maternal sites, the retrieved evidence lacks direct, longitudinal studies correlating specific gestational maternal microbiota profiles with the *long-term* metabolic health of offspring, leaving the core question unresolved.

Sources

Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus — Gut, 2018
Dysbiosis of the gut microbiota in disease — Microbial Ecology in Health and Disease, 2015
Temporal development of the gut microbiome in early childhood from the TEDDY study — Nature, 2018
Microbiota in health and diseases — Signal Transduction and Targeted Therapy, 2022
Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis — Hormone and Metabolic Research, 2024
Perinatal phlorizin alleviates maternal high-fat diet-induced metabolic syndrome in female mouse offspring and is associated with modulation of the gut microbiota. — Frontiers in nutrition, 2026
Offspring long-term infectious morbidity following pregnancies with cervical cerclage. — Archives of gynecology and obstetrics, 2026
Interaction between microbiota and immunity in health and disease — Cell Research, 2020
Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions. — Journal of translational medicine, 2026
Microbes in the Moonlight: How the Gut Microbiota Influences Sleep — arXiv preprint, 2025

What are the long-term developmental and health outcomes in children born to mothers who experienced COVID-19-related mental health stressors compared to those who did not, controlling for socioeconomic status?

Why this gap exists: While recent studies [0, 5, 6] link pandemic-related maternal distress to child neurodevelopmental issues, the retrieved evidence focuses on general pandemic exposure rather than specifically isolating COVID-19 mental health stressors while controlling for socioeconomic status, leaving the specific comparison unresolved.

Sources