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Otchere Addai‐Mensah

Kwame Nkrumah University of Science and Technology

67 publications · 1,002 citations · ORCID 0000-0001-9225-5876

Malaria Research and ControlPregnancy and preeclampsia studiesMosquito-borne diseases and controlIron Metabolism and DisordersClinical Laboratory Practices and Quality Control

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Otchere Addai‐Mensah is a biomedical researcher specializing in hematology, clinical immunology, and infectious diseases, with a strong focus on malaria and coagulation disorders in Ghanaian populations. Addai‐Mensah investigates the pathophysiology of malaria-related anemia, the utility of diagnostic biomarkers for infectious and non-communicable diseases, and the immunological correlates of protection against malaria. The research portfolio spans laboratory-based studies on monoclonal antibodies and genetic diversity to clinical evaluations of coagulation profiles and metabolic syndrome.

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How do specific cultural beliefs regarding 'insufficient milk' in rural South African communities mediate the relationship between maternal dietary diversity and the introduction of prelacteal feeds?

Why this gap exists: While the retrieved papers discuss general breastfeeding barriers in South Africa [8] and cultural influences in other regions like Ethiopia [6] and Malaysia [9], none specifically address the mediation of 'insufficient milk' beliefs on the relationship between maternal dietary diversity and prelacteal feeds in rural South African communities.

Sources

  1. African Political Systems. — American Sociological Review, 1940
  2. Maternal nutrition counselling is associated with reduced stunting prevalence and improved feeding practices in early childhood: a post-program comparison study — Nutrition Journal, 2019
  3. Trends and determinants of early initiation of breastfeeding and exclusive breastfeeding in Ethiopia from 2000 to 2016 — International Breastfeeding Journal, 2019
  4. Marketing of commercial milk formula: a system to capture parents, communities, science, and policy — The Lancet, 2023
  5. Facilitators, barriers, and factors determining the willingness to donate human milk among postpartum mothers in a tertiary women's hospital in Nepal: a cross-sectional study. — International breastfeeding journal, 2026
  6. Assessment of Infant and Young Child Feeding Practices among Mothers Attending Maternal and Child Health Clinic at a Tertiary Hospital, North Karnataka, India - A Cross-sectional Study. — Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine, 2025
  7. Sociocultural and structural influences on infant and young child feeding in pastoralist communities of Afar, Ethiopia: a qualitative phenomenological study. — BMJ open, 2026
  8. Knowledge, attitude, and practice of exclusive breastfeeding among mothers in East Africa: a systematic review — International Breastfeeding Journal, 2020
  9. Facilitators and barriers associated with breastfeeding among mothers attending primary healthcare facilities in Mpumalanga, South Africa. — Frontiers in nutrition, 2023
  10. Assessing the Influence of Cultural Beliefs and Practices on Early Breastfeeding Initiation Rates in Rural Sarawak Communities, Malaysia — Scientific Journal of Pediatrics, 2023

What is the comparative efficacy and cost-effectiveness of the one-step 75g OGTT versus the two-step (50g GCT followed by 100g OGTT) diagnostic approach in preventing adverse maternal and neonatal outcomes?

Why this gap exists: While Abstract [7] compares diagnostic criteria and Abstract [4] compares 75g and 100g OGTTs, the retrieved evidence lacks direct, comparative studies on the cost-effectiveness and relative efficacy of the one-step versus two-step *approaches* in preventing adverse outcomes, leaving the specific question unresolved.

Sources

  1. Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO Criteria — PLoS ONE, 2016
  2. A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes — New England Journal of Medicine, 2009
  3. Standards of Medical Care in Diabetes—2013 — Diabetes Care, 2012
  4. An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative Review — Diabetes Metabolic Syndrome and Obesity, 2021
  5. Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to detect gestational diabetes mellitus — Frontiers in Endocrinology, 2025
  6. Large language models for generating longitudinal synthetic data in low-risk pregnancy care. — Data in brief, 2026
  7. Effects of physical activity and diet in pregnancy to prevent gestational diabetes: an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation. — Health technology assessment (Winchester, England), 2026
  8. 187-OR: Randomized Clinical Trial of the IADPSG vs. Carpenter Coustan Criteria for Diagnosis of Gestational Diabetes Mellitus — Diabetes, 2020
  9. Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A cross-sectional study. — Diabetes & metabolic syndrome, 2019
  10. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026

To what extent does maternal access to improved water and sanitation facilities mediate the relationship between maternal undernutrition and child developmental outcomes during the first 1,000 days?

Why this gap exists: While the retrieved papers confirm the individual importance of WASH access for child nutrition [0], maternal undernutrition for child development [5, 8], and the critical nature of the first 1,000 days [5], none of the provided abstracts directly analyze the specific mediating role of water and sanitation facilities in the relationship between maternal undernutrition and child developmental outcomes.

Sources

  1. Household water, sanitation, and hygiene access and its impact on nutritional outcomes in children under five: evidence from Pakistan. — BMC public health, 2026
  2. Early childhood development and stunting: Findings from the MAL‐ED birth cohort study in Bangladesh — Maternal and Child Nutrition, 2019
  3. Policy and Structural Drivers of Malnutrition in Afghan Women: Evidence and Interventions. — International journal of women's health, 2026
  4. COVID-19 pandemic and mitigation strategies: implications for maternal and child health and nutrition — American Journal of Clinical Nutrition, 2020
  5. Maternal and child undernutrition 3: what works? Interventions for maternal and child undernutrition and survival — Child: Care, Health and Development, 2008
  6. Nutrition as the Foundation of Human Capital: Pathways to Holistic Development. — Maternal & child nutrition, 2026
  7. The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring. — The British journal of nutrition, 2017
  8. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  9. Prevalence of undernutrition and its associated factors among pregnant women attending antenatal care service in public hospitals in Mogadishu, Somalia. — PloS one, 2026
  10. Concurrent wasting and stunting among under‐five children in Niakhar, Senegal — Maternal & Child Nutrition, 2018

What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

  1. New developments in tuberculosis diagnosis and treatment — Breathe, 2022
  2. Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
  3. Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
  4. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
  5. Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
  6. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
  7. Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
  8. Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
  9. Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
  10. Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

How do specific maternal microbiota profiles (gut, oral, or vaginal) during gestation correlate with the development of gestational diabetes mellitus (GDM) and subsequent long-term metabolic health in offspring?

Why this gap exists: While recent reviews [8] confirm GDM alters maternal gut microbiota and neonatal health, and older studies [0] note dysbiosis across maternal sites, the retrieved evidence lacks direct, longitudinal studies correlating specific gestational maternal microbiota profiles with the *long-term* metabolic health of offspring, leaving the core question unresolved.

Sources

  1. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus — Gut, 2018
  2. Dysbiosis of the gut microbiota in disease — Microbial Ecology in Health and Disease, 2015
  3. Temporal development of the gut microbiome in early childhood from the TEDDY study — Nature, 2018
  4. Microbiota in health and diseases — Signal Transduction and Targeted Therapy, 2022
  5. Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis — Hormone and Metabolic Research, 2024
  6. Perinatal phlorizin alleviates maternal high-fat diet-induced metabolic syndrome in female mouse offspring and is associated with modulation of the gut microbiota. — Frontiers in nutrition, 2026
  7. Offspring long-term infectious morbidity following pregnancies with cervical cerclage. — Archives of gynecology and obstetrics, 2026
  8. Interaction between microbiota and immunity in health and disease — Cell Research, 2020
  9. Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions. — Journal of translational medicine, 2026
  10. Microbes in the Moonlight: How the Gut Microbiota Influences Sleep — arXiv preprint, 2025

To what extent do changes in the maternal microbiota (gut, oral, or vaginal) during pregnancy mediate the relationship between maternal perinatal anxiety/depression and the neurodevelopmental outcomes of the offspring?

Why this gap exists: While recent studies confirm associations between maternal mental health and microbiota composition (Abstract 5, 8) and suggest the microbiome-gut-brain axis influences neurodevelopment (Abstract 0, 2), the retrieved evidence does not contain studies that directly test the mediating role of maternal microbiota changes between perinatal anxiety/depression and offspring neurodevelopmental outcomes.

Sources

  1. Parental microbiome programming of early-life neurodevelopment: multi-niche contributions through the microbiome-gut-brain axis. — Gut microbes, 2026
  2. Dysbiosis of the gut microbiota in disease — Microbial Ecology in Health and Disease, 2015
  3. Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner — Scientific Reports, 2017
  4. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication — Frontiers in Endocrinology, 2020
  5. Ultra-processed food consumption across early life: implications for pediatric health and disease risk. — Frontiers in nutrition, 2026
  6. Mental health in early pregnancy: Interplay of objectively measured lifestyles, gut microbiota, and metabolomics. — iScience, 2026
  7. The impact of maternal high-fat diet on offspring neurodevelopment — Frontiers in Neuroscience, 2022
  8. Maternal education and offspring birthweight for gestational age: the mediating effect of smoking during pregnancy — arXiv preprint, 2020
  9. Is Gut Microbiota Altered in Depression and Anxiety? — 2025
  10. Vaginal Microbiota: A Critical Component of Reproductive Health and Pregnancy Outcomes — Vaginal Microbiota: A Critical Component of Reproductive Health and Pregnancy Outcomes, 2025

Publications

Rapid Measurement of Erythrocyte Sedimentation Rate Using a Tube Positioned at a 45° Angle Compared With the Westergren Reference Method

BioMed Research International · 2026

Diagnostic utility of fibrinolytic markers as indicators of pediatric Plasmodium falciparum malaria: a case-control study in the Offinso-North District, Ghana

Research Square · 2026

Serum Anti‐Erythropoietin Autoantibodies and Their Association With Younger Age in Paediatric Malaria Cases

BioMed Research International · 2025 · corresponding author

Anaemia during pregnancy: a cross-sectional study of antenatal attendants at the Madina Pentecost Hospital, La Nkwantanang Municipality, Ghana

Cogent Public Health · 2024 · 2 citations

Diagnostic value of neutrophil gelatinase-associated lipocalin and neutrophil-to-lymphocyte ratio in type 2 diabetes mellitus individuals with reduced estimated glomerular filtration rate(eGFR): A case-control study in a municipal hospital in Ghana

medRxiv · 2024

Coagulation Factors and Natural Anticoagulants as Surrogate Markers of Preeclampsia and Its Subtypes: A Case–Control Study in a Ghanaian Population

Clinical and Applied Thrombosis/Hemostasis · 2023 · 9 citations

Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women

SAGE Open Medicine · 2023 · 7 citations

Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana

Health Science Reports · 2023 · corresponding author · 3 citations

Biomarkers of oxidative stress and its nexus with haemoglobin variants and adverse foeto-maternal outcome among women with preeclampsia in a Ghanaian population: A multi-centre prospective study

PLoS ONE · 2023 · corresponding author · 3 citations

Plasma levels of fibrinolytic and coagulation biomarkers in HIV‐infected individuals on highly active antiretroviral therapy: A case‐control study in a Northern Ghanaian population

Health Science Reports · 2023 · 2 citations

Prevalence of Cardiometabolic Syndrome and its Association With Body Shape Index and A Body Roundness Index Among Type 2 Diabetes Mellitus Patients: A Hospital-Based Cross-Sectional Study in a Ghanaian Population

Frontiers in Clinical Diabetes and Healthcare · 2022 · 24 citations

Prevalence and risk factors of malaria and anaemia and the impact of preventive methods among pregnant women: A case study at the Akatsi South District in Ghana

PLoS ONE · 2022 · 23 citations

Prevalence and Risk Factors of Preterm Birth Among Pregnant Women Admitted at the Labor Ward of the Komfo Anokye Teaching Hospital, Ghana

Frontiers in Global Women s Health · 2022 · 16 citations

Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia

PLoS ONE · 2022 · 8 citations

Effect of pulmonary tuberculosis on natural anticoagulant activity in therapy-naïve Ghanaian adults; a case-control study

Journal of Immunoassay and Immunochemistry · 2022 · 6 citations

Haematological Profile in Pre-Surgery Hernia Patients: A Case-Control Study in Ghana

SciMedicine Journal · 2022 · 2 citations

Interplay between foetal haemoglobin, micronutrients and oxidative stress biomarkers in sickle cell anaemia children

Human Nutrition & Metabolism · 2022 · corresponding author · 1 citations

Effects of Buffer Substitution on Rapid Diagnostic Tests for Malaria Diagnosis

Research Square · 2022

Patterns of hernia, haematological profile, and predictive ability of blood cell indices in pre-surgery patients; A case-control study in a district hospital in Ghana

Research Square · 2022

Novel prognostic Potential of Early Second Trimester and Mid-pregnancy 8-hydroxy-2-deoxyguanosine/Placental growth factor ratio for preeclampsia: A Longitudinal Nested-Case Control Study

2022

Reference intervals for selected haematological and biochemical parameters among apparently healthy adults in different eco-geographical zones in Ghana

PLoS ONE · 2021 · corresponding author · 23 citations

Plasminogen Activator Inhibitor-1 in poorly controlled vs well controlled Type-2 Diabetes Mellitus patients: A case-control study in a district hospital in Ghana

PLoS ONE · 2021 · 17 citations

Isolation and light chain shuffling of a Plasmodium falciparum AMA1-specific human monoclonal antibody with growth inhibitory activity

Malaria Journal · 2021 · 12 citations

Early gestational profiling of oxidative stress and angiogenic growth mediators as predictive, preventive and personalised (3P) medical approach to identify suboptimal health pregnant mothers likely to develop preeclampsia

The EPMA Journal · 2021 · 8 citations

Acute Phase Responses Vary Between Children of HbAS and HbAA Genotypes During Plasmodium falciparum Infection

Journal of Inflammation Research · 2021 · 4 citations

Coagulation abnormalities in childhood acute lymphoblastic leukemia: assessing the impact of L-asparaginase therapy in Ghana

Thrombosis Journal · 2021 · corresponding author · 4 citations

Malaria and Anaemia: Prevalence, Risk Factors and Impact of Preventive Methods among Pregnant Women in the Akatsi South District, Ghana: A Hospital-Based Cross-Sectional Study

Research Square · 2021

A multicenter study of the prevalence and risk factors of malaria and anemia among pregnant women at first antenatal care visit in Ghana

PLoS ONE · 2020 · 58 citations

Plasmodium falciparum histidine-rich protein 2 diversity in Ghana

Malaria Journal · 2020 · corresponding author · 50 citations

Assessment of platelet indices and platelet activation markers in children with Plasmodium falciparum malaria

Malaria Journal · 2020 · 14 citations

SARS-CoV-2 updates in a West African population and precautionary measures for sustaining quality antenatal care delivery

Journal of Global Health · 2020 · 7 citations

Population-derived cut-off for HbA1c could enhance the identification of metabolic syndrome among non-diabetic population

Heliyon · 2020 · 6 citations

Comediation of Erythrocyte Haemolysis by Erythrocyte-Derived Microparticles and Complement during Malaria Infection

Advances in Hematology · 2020 · 4 citations

Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment

American Journal of Laboratory Medicine · 2020 · 4 citations

Molecular Characterization of Glucose-6-Phosphate Dehydrogenase: Do Single Nucleotide Polymorphisms Affect Hematological Parameters in HIV-Positive Patients?

Journal of Tropical Medicine · 2020 · corresponding author · 3 citations

Fetal Rhesus D Genotyping and Sex Determination from Maternal Plasma of Rhesus D-Negative Antenatal Population: The Usefulness of Conventional Polymerase Chain Reaction in Resource-limited Settings

Obstetrics and Gynecology International · 2020 · corresponding author · 1 citations

Molecular characterization of Glucose-6-Phosphate Dehydrogenase: do single nucleotide polymorphisms affect hematological parameters in HIV positive patients?

Research Square (Research Square) · 2020 · 1 citations

Effect of Pulmonary Tuberculosis on Protein C, S, and Antithrombin-III among Therapy-naïve Ghanaian Adults; A Comparative Cross-Sectional Study

Research Square · 2020

Plasmodium falciparum histidine-rich protein 2 (PfHRP2) diversity in Ghana

Research Square · 2020 · corresponding author

Effect of Pulmonary tuberculosis on natural anticoagulant activity in therapy-naive Ghanaian adults; a case-control study.

Harvard Dataverse · 2020

Predominant Complications of Type 2 Diabetes in Kumasi: A 4-Year Retrospective Cross-Sectional Study at a Teaching Hospital in Ghana

Medicina · 2019 · 38 citations

Hepatitis B and C infections in HIV-1 and non-HIV infected pregnant women in the Brong-Ahafo Region, Ghana

PLoS ONE · 2019 · 35 citations

Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

Frontiers in Immunology · 2019 · 29 citations

Determination of Haematological Reference Ranges in Healthy Adults in Three Regions in Ghana

BioMed Research International · 2019 · 29 citations

Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus

PLoS ONE · 2019 · corresponding author · 17 citations

High-Sensitivity C-Reactive Protein: A Potential Ancillary Biomarker for Malaria Diagnosis and Morbidity

Disease Markers · 2019 · 16 citations

Diagnosis of bacterial meningitis in Ghana: Polymerase chain reaction versus latex agglutination methods

PLoS ONE · 2019 · 12 citations

Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans

The Scientific World JOURNAL · 2019 · corresponding author · 10 citations

Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma

Leukemia Research · 2019 · 9 citations

Regular Antenatal Attendance and Education Influence the Uptake of Intermittent Preventive Treatment of Malaria in Pregnancy: A Cross-Sectional Study at the University Hospital, Kumasi, Ghana

Journal of Tropical Medicine · 2018 · corresponding author · 45 citations

Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria

Scientific Reports · 2018 · 37 citations

Author Correction: Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria

Scientific Reports · 2018 · 4 citations

Adequate Exercise Improves Inflammatory, Gonadal Markers and Sexual Function in Type 2 Diabetics

Journal of Advances in Medicine and Medical Research · 2018 · 1 citations

Reference Intervals of Prothrombin Time and Activated Partial Thromboplastin Time and Their Association with Age among Healthy Adults in Kumasi, Ghana

HAL (Le Centre pour la Communication Scientifique Directe) · 2018

Lipid profile, cardiorespiratory function and quality of life of postmenopausal women improves with aerobic exercise

Journal of Human Sport and Exercise · 2017 · 18 citations

Differences in Haematological and Biochemical Parameters of Athletes and Non-Athletes

Journal of Advances in Medicine and Medical Research · 2017 · 5 citations

Characterization of a novel inhibitory human monoclonal antibody directed against Plasmodium falciparum Apical Membrane Antigen 1

Scientific Reports · 2016 · 34 citations

Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria

Malaria Journal · 2016 · 4 citations

Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10

Malaria Journal · 2015 · 23 citations

Safety of Family Replacement Donors vs. Voluntary Non-Remunerated Donors in Komfo Anokye Teaching Hospital, Ghana: A Comparative Study

Journal of Medical and Biomedical Sciences · 2015 · 12 citations

Establishment of a phage display platform for the isolation of plasmodium falciparum specific monoclonal antibodies

RWTH Publications (RWTH Aachen) · 2015

Plant-Based Production of Recombinant Plasmodium Surface Protein Pf38 and Evaluation of its Potential as a Vaccine Candidate

PLoS ONE · 2013 · 36 citations

Renal insufficiency in Ghanaian HIV infected patients: need for dose adjustment

African Health Sciences · 2013 · 23 citations

Prevalence of anaemia and immunological markers among ghanaian HAART-naïve HIV-patients and those on HAART.

PubMed · 2011 · 71 citations

Incidence of sexual dysfunction: a prospective survey in Ghanaian females

Reproductive Biology and Endocrinology · 2010 · 97 citations

Prevalence of male sexual dysfunction among Ghanaian populace: myth or reality?

International Journal of Impotence Research · 2010 · 61 citations

Seroprevalence and Risk Factors for Human Immunodeficiency Virus, Hepatitis B and C Vi-ruses Infections among Blood Donors at the Bolgatanga Regional Hospital in Bolgatanga, Ghana

Journal of the Ghana Science Association · 2010 · 14 citations