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Samuel Antwi‐Baffour

London Metropolitan University

67 publications · 1,041 citations · ORCID 0000-0002-7653-1129

Extracellular vesicles in diseaseMalaria Research and ControlHemoglobinopathies and Related DisordersBlood groups and transfusionIron Metabolism and Disorders

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Samuel Antwi‐Baffour specializes in hematology, immunology, and the study of extracellular vesicles, with a strong focus on infectious diseases like malaria and transfusion medicine. Antwi‐Baffour investigates the role of plasma membrane-derived vesicles in disease pathogenesis, the hematological impacts of malaria and diabetes, and the safety of the blood supply in Ghana. The research profile spans from basic molecular characterization of microvesicles to clinical evaluations of blood donors and patients with metabolic or infectious conditions.

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How do specific maternal microbiota profiles (gut, oral, or vaginal) during gestation correlate with the development of gestational diabetes mellitus (GDM) and subsequent long-term metabolic health in offspring?

Why this gap exists: While recent reviews [8] confirm GDM alters maternal gut microbiota and neonatal health, and older studies [0] note dysbiosis across maternal sites, the retrieved evidence lacks direct, longitudinal studies correlating specific gestational maternal microbiota profiles with the *long-term* metabolic health of offspring, leaving the core question unresolved.

Sources

  1. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus — Gut, 2018
  2. Dysbiosis of the gut microbiota in disease — Microbial Ecology in Health and Disease, 2015
  3. Temporal development of the gut microbiome in early childhood from the TEDDY study — Nature, 2018
  4. Microbiota in health and diseases — Signal Transduction and Targeted Therapy, 2022
  5. Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis — Hormone and Metabolic Research, 2024
  6. Perinatal phlorizin alleviates maternal high-fat diet-induced metabolic syndrome in female mouse offspring and is associated with modulation of the gut microbiota. — Frontiers in nutrition, 2026
  7. Offspring long-term infectious morbidity following pregnancies with cervical cerclage. — Archives of gynecology and obstetrics, 2026
  8. Interaction between microbiota and immunity in health and disease — Cell Research, 2020
  9. Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions. — Journal of translational medicine, 2026
  10. Microbes in the Moonlight: How the Gut Microbiota Influences Sleep — arXiv preprint, 2025

What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

  1. New developments in tuberculosis diagnosis and treatment — Breathe, 2022
  2. Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
  3. Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
  4. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
  5. Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
  6. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
  7. Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
  8. Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
  9. Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
  10. Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

How does the consumption of plant-based proteins, specifically those high in anti-nutritional factors like phytates and trypsin inhibitors, affect mineral bioavailability and growth outcomes in children relying on these proteins as primary staples?

Why this gap exists: While the retrieved papers confirm that anti-nutritional factors like phytates and trypsin inhibitors reduce mineral bioavailability [0, 2], they focus on general adult health or crop improvement [1, 6] and do not provide direct evidence on the specific growth outcomes in children relying on these proteins as primary staples.

Sources

  1. Plant food anti-nutritional factors and their reduction strategies: an overview — Food Production Processing and Nutrition, 2020
  2. Sustaining Protein Nutrition Through Plant-Based Foods — Frontiers in Nutrition, 2022
  3. Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds — Nutrients, 2020
  4. Faba Bean: An Untapped Source of Quality Plant Proteins and Bioactives — Nutrients, 2022
  5. Nutritional properties and health aspects of pulses and their use in plant‐based yogurt alternatives — Comprehensive Reviews in Food Science and Food Safety, 2021
  6. Grains – a major source of sustainable protein for health — Nutrition Reviews, 2021
  7. Healthy and Resilient Cereals and Pseudo-Cereals for Marginal Agriculture: Molecular Advances for Improving Nutrient Bioavailability — Frontiers in Genetics, 2020
  8. Protein Quality in Perspective: A Review of Protein Quality Metrics and Their Applications — Nutrients, 2022
  9. Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases — Nutrients, 2021
  10. Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits — Frontiers in Nutrition, 2020

What are the specific long-term treatment strategies required to mitigate the risk of developing chronic non-communicable diseases in children born to mothers with gestational diabetes mellitus?

Why this gap exists: While the retrieved literature consistently establishes that maternal gestational diabetes mellitus (GDM) increases the long-term risk of cardiometabolic diseases in offspring [1][2][3], it focuses primarily on pathogenesis and risk association rather than defining specific, evidence-based long-term treatment strategies for the children to mitigate these risks.

Sources

  1. Diagnosis and Classification of Diabetes Mellitus — Diabetes Care, 2010
  2. A Clinical Update on Gestational Diabetes Mellitus — Endocrine Reviews, 2022
  3. Maternal Diabetes and Risk of Early-Onset Cardiovascular Diseases in Offspring. — JAMA cardiology, 2026
  4. Gestational diabetes as an inter-generational cardiometabolic risk factor: spotlight on emerging exerkines. — Cardiovascular diabetology, 2026
  5. Gestational diabetes: from pathogenesis to therapeutic intervention. — Diabetology & metabolic syndrome, 2026
  6. 2. Classification and Diagnosis of Diabetes:<i>Standards of Medical Care in Diabetes—2022</i> — Diabetes Care, 2021
  7. Maternal congenital heart disease and risk of child developmental vulnerability in early school age: A population-based cohort study. — PLoS medicine, 2026
  8. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026
  9. Gestational Diabetes and Obesity: Immediate and Late Sequelae for Offspring. — Children (Basel, Switzerland), 2025
  10. Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications — Diabetes & Metabolism Journal, 2022

What is the comparative efficacy of household water treatment interventions versus improved water source infrastructure in reducing stunting among children under five in low- and middle-income countries?

Why this gap exists: While the retrieved literature confirms associations between water quality and child growth (e.g., Abstracts 2, 5, 8), no study directly compares the efficacy of household water treatment interventions against improved water source infrastructure for reducing stunting, leaving the specific comparative question unresolved.

Sources

  1. Determinants of stunting in Indonesian children: evidence from a cross-sectional survey indicate a prominent role for the water, sanitation and hygiene sector in stunting reduction — BMC Public Health, 2016
  2. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  3. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trial — The Lancet Global Health, 2018
  4. Effects of Water Pollution on Human Health and Disease Heterogeneity: A Review — Frontiers in Environmental Science, 2022
  5. Associated factors with malnutrition among children under-5 years old in Somaliland: evidence from Somaliland health and demographic survey of 2020. — BMC public health, 2026
  6. Safe Drinking Water and Its Impact on Children's Growth and Development: A Systematic Review. — International journal of environmental research and public health, 2026
  7. Modelling the impact of dietary diversity on child nutrition in Pakistan: a machine learning analysis with Shapley Additive exPlanations and Boruta interpretability. — Journal of global health, 2026
  8. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis — The Lancet, 2022
  9. Effect of Household Source of Drinking Water on Malnutrition among under Five Children in Ethiopia: Systematic Review and Meta-Analysis — 2026
  10. Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields — Water 2017, 9, 339, 2018

To what extent does maternal access to improved water and sanitation facilities mediate the relationship between maternal undernutrition and child developmental outcomes during the first 1,000 days?

Why this gap exists: While the retrieved papers confirm the individual importance of WASH access for child nutrition [0], maternal undernutrition for child development [5, 8], and the critical nature of the first 1,000 days [5], none of the provided abstracts directly analyze the specific mediating role of water and sanitation facilities in the relationship between maternal undernutrition and child developmental outcomes.

Sources

  1. Household water, sanitation, and hygiene access and its impact on nutritional outcomes in children under five: evidence from Pakistan. — BMC public health, 2026
  2. Early childhood development and stunting: Findings from the MAL‐ED birth cohort study in Bangladesh — Maternal and Child Nutrition, 2019
  3. Policy and Structural Drivers of Malnutrition in Afghan Women: Evidence and Interventions. — International journal of women's health, 2026
  4. COVID-19 pandemic and mitigation strategies: implications for maternal and child health and nutrition — American Journal of Clinical Nutrition, 2020
  5. Maternal and child undernutrition 3: what works? Interventions for maternal and child undernutrition and survival — Child: Care, Health and Development, 2008
  6. Nutrition as the Foundation of Human Capital: Pathways to Holistic Development. — Maternal & child nutrition, 2026
  7. The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring. — The British journal of nutrition, 2017
  8. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  9. Prevalence of undernutrition and its associated factors among pregnant women attending antenatal care service in public hospitals in Mogadishu, Somalia. — PloS one, 2026
  10. Concurrent wasting and stunting among under‐five children in Niakhar, Senegal — Maternal &amp; Child Nutrition, 2018

Publications

Integrative proteomic profiling of malaria-derived microparticles: A mass spectrometry–based study

Open MIND · 2026

Integrative proteomic profiling of malaria-derived microparticles: A mass spectrometry-based study.

PubMed · 2026

Submicroscopic Malaria Parasite Carriage and Hemoglobin Levels among Individuals with Asymptomatic Malaria Infections

Research Square · 2026

Integrative proteomic profiling of malaria-derived microparticles: A mass spectrometry–based study

Zenodo (CERN European Organization for Nuclear Research) · 2026

In differentiated HL-60 neutrophil-like cells, MRP1- (ABCC1-) mediated glutathione efflux stimulated by BzATP and P2X <sub>7</sub> receptor signalling regulates exosome release through nSMase activity

bioRxiv (Cold Spring Harbor Laboratory) · 2026

Overview of the host immune response to P. falciparum malaria

Journal of Parasitic Diseases · 2025 · corresponding author · 2 citations

Evaluation of Iron Levels and Hematological Indices Among Blood Donors at the Southern Zonal Blood Center, Accra, Ghana

SSRN Electronic Journal · 2025 · corresponding author

Evaluation of iron levels and hematological indices among blood donors at the Southern Zonal Blood Center, Accra, Ghana

Transfusion and Apheresis Science · 2025 · corresponding author

Comparative evaluation of RT-PCR and antigen-based rapid diagnostic tests (Ag-RDTs) for SARS-CoV-2 detection: performance, variant specificity, and clinical implications

Microbiology Spectrum · 2024 · 8 citations

Molecular Epidemiology of SARS-CoV-2 within Accra Metropolis Postlockdown

Advances in Virology · 2024 · 2 citations

Evaluation of immunophenotypic alterations of peripheral blood lymphocytes and their sub-sets in uncomplicated P. Falciparum infection

BMC Immunology · 2024 · corresponding author · 1 citations

Comparison of Glycated Haemoglobin with Coagulation and Biochemical Profile of Patients with Type II Diabetes Mellitus

Research Square · 2024 · 1 citations

Comorbidity of Hyperglycemia and Dyslipidemia among Factory Workers: A Study on the Interrelationship of Metabolic Disorders in Occupational Settings

Journal of Diabetes and Clinical Research · 2024

A cross-sectional study of the Evaluation of Iodine Deficiency among Pregnant Women Attending Antenatal Clinic at a Community Health Centre

Research Square · 2024

Association of Glycated Hemoglobin with Coagulation and Biochemical Profiles in Type II Diabetes Patients – a Case Control Study

Research Square · 2024

Human Parvovirus B19 Infections among Blood Donors in Selected Blood Centers in Ghana

Journal of Biotechnology and Biomedicine · 2024

Haematological parameters and their correlation with the degree of malaria parasitaemia among outpatients attending a polyclinic

Malaria Journal · 2023 · corresponding author · 27 citations

Comparative analysis of glycated haemoglobin, fasting blood glucose and haematological parameters in Type-2 diabetes patients

BMC Research Notes · 2023 · corresponding author · 13 citations

Human Parvovirus B19 Infections among Blood Donors in Selected Blood Centers in Ghana

Research Square · 2023 · 1 citations

Haematological Parameters and Their Correlation With the Degree of Malaria Parasitaemia Among Outpatients Attending a Polyclinic

Research Square · 2023 · corresponding author · 1 citations

Comparative Analysis of Glycated Haemoglobin, Fasting Blood Glucose and Haematological Parameters of Type-2 Diabetes Patients

Research Square · 2023

Evaluation of Immunophenotypic Alterations of Peripheral Blood Lymphocytes and their Sub-Sets in Uncomplicated P. Falciparum Infection

Research Square · 2023 · corresponding author

Seroprevalence and effect of HBV and HCV co-infections on the immuno-virologic responses of adult HIV-infected persons on anti-retroviral therapy

PLoS ONE · 2022 · 8 citations

Identification of Serum Cytokine Biomarkers Associated with Multidrug Resistant Tuberculosis (MDR-TB)

Immuno · 2021 · 7 citations

Comediation of Erythrocyte Haemolysis by Erythrocyte-Derived Microparticles and Complement during Malaria Infection

Advances in Hematology · 2020 · 4 citations

Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets

Journal of Extracellular Vesicles · 2019 · 33 citations

Comorbidity of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease Exert Significant Effect on RBC Indices

Anemia · 2019 · corresponding author · 27 citations

A Study of the Change in Sodium and Potassium Ion Concentrations in Stored Donor Blood and Their Effect on Electrolyte Balance of Recipients

BioMed Research International · 2019 · corresponding author · 21 citations

The Incidence of Malaria Parasites in Screened Donor Blood for Transfusion

Malaria Research and Treatment · 2019 · corresponding author · 9 citations

Severity of Anaemia Has Corresponding Effects on Coagulation Parameters of Sickle Cell Disease Patients

Diseases · 2019 · corresponding author · 8 citations

Selected Candidate Genes and Obesity Among Ghanaian Adults: A Case-control Study at the Korle-Bu Teaching Hospital (Dietherapy Unit) Accra (P15-014-19)

Current Developments in Nutrition · 2019 · 1 citations

Severity of Anaemia has Corresponding Effects on Coagulation Parameters of Sickle Cell Disease Patients

Preprints.org · 2019 · 1 citations

Haematological parameters and lipid profile abnormalities among patients with Type-2 diabetes mellitus in Ghana

Lipids in Health and Disease · 2018 · corresponding author · 46 citations

Plasma Levels of Cytokines (IL-10, IFN-γ and TNF-α) in Multidrug Resistant Tuberculosis and Drug Responsive Tuberculosis Patients in Ghana

Diseases · 2018 · 28 citations

Correlation of malaria parasitaemia with peripheral blood monocyte to lymphocyte ratio as indicator of susceptibility to severe malaria in Ghanaian children

Malaria Journal · 2018 · corresponding author · 26 citations

RETRACTED ARTICLE: Proteomic analysis of microparticles isolated from malaria positive blood samples

Proteome Science · 2017 · corresponding author · 29 citations

The relative merits of therapies being developed to tackle inappropriate (‘self’-directed) complement activation

Autoimmunity Highlights · 2016 · corresponding author · 3 citations

Plasma Membrane- Derived Vesicles Shows Effects on the Induction of Differentiation of Promonocytes into Macrophages: A Possible Cancer Therapy

MOJ Immunology · 2016 · corresponding author

Understanding the biosynthesis of platelets‐derived extracellular vesicles

Immunity Inflammation and Disease · 2015 · corresponding author · 41 citations

Prevalence of hemoglobin S trait among blood donors: a cross-sectional study

BMC Research Notes · 2015 · corresponding author · 34 citations

Relationship between oxidative stress and haematological indices in patients with diabetes in the Ghanaian population

Clinical Diabetes and Endocrinology · 2015 · 24 citations

Molecular characterisation of plasma membrane-derived vesicles

Journal of Biomedical Science · 2015 · corresponding author · 22 citations

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9

Biochemical and Biophysical Research Communications · 2015 · 17 citations

Anemia in prospective blood donors deferred by the copper sulphate technique of hemoglobin estimation

BMC Hematology · 2015 · corresponding author · 15 citations

Storage of Blood for Transfusion in Domestic Refrigerators: Any Immune Consequences?

OALib · 2015 · 1 citations

Prolonged Storage of Red Blood Cells for Transfusion in Citrate Phosphate Dextrose Adenine-1 Affects Their Viability

OALib · 2015 · 1 citations

Biological Functions of Plasma Membrane-Derived Extracellular Vesicles and Their Role in Diseases

Journal of Cells · 2015

The Place of Traditional Medicine in the African Society: The Science, Acceptance and Support

American Journal of Health Research · 2014 · corresponding author · 49 citations

Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance

Biochemical and Biophysical Research Communications · 2014 · 15 citations

Incidence of Hepatitis B Surface Antigen among Sickle Cell Disease Patients Receiving Transfusion Therapy

International Journal of Biomedical Science and Engineering · 2014 · corresponding author · 6 citations

Alterations in Plasma Glucose Levels among Blood Donors

European Journal of Preventive Medicine · 2014 · corresponding author

Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal

UCL Discovery (University College London) · 2014

Blood/plasma secretome and microvesicles

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2013 · 106 citations

Prolong Storage of Blood in EDTA Has an Effect on the Morphology and Osmotic Fragility of Erythrocytes

International Journal of Biomedical Science and Engineering · 2013 · corresponding author · 50 citations

Plasma Membrane-derived Vesicles (PMVs) in G6PD Deficient Patients

SOJ Immunology · 2013 · corresponding author · 4 citations

Plasma Membrane-Derived Vesicles in Sickle Cell Disease: A Possible Indicator of the Continuous Endothelial Stimulation and/or Injury to Blood Cells

American Journal of Biomedical and Life Sciences · 2013 · corresponding author · 4 citations

Foetomaternal Haemorrhage (FMH): A Case for Routine Screening

Journal of Gynecology and Obstetrics · 2013 · corresponding author

Microvesicles in Health and Disease

Archivum Immunologiae et Therapiae Experimentalis · 2012 · 66 citations

Microvessels in health and disease.

2012

Two subtypes of microvesicles can be isolated from tissue culture (174.17)

The Journal of Immunology · 2012

Isolation of microvesicles and exosomes by filtration and estimation of normal reference range in blood plasma

WestminsterResearch (University of Westminster) · 2012

Characterisation of microvesicles released from cells constitutively and upon stimulation

University of Hertfordshire Research Archive (University of Hertfordshire) · 2012

A filtration-based protocol to isolate human Plasma Membrane-derived Vesicles and exosomes from blood plasma

Journal of Immunological Methods · 2011 · 140 citations

Human Plasma Membrane-Derived Vesicles Halt Proliferation and Induce Differentiation of THP-1 Acute Monocytic Leukemia Cells

The Journal of Immunology · 2010 · 58 citations

Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells – Possible role in SLE

Biochemical and Biophysical Research Communications · 2010 · 49 citations

Red cell PMVs, plasma membrane-derived vesicles calling out for standards

Biochemical and Biophysical Research Communications · 2010 · 33 citations

Antiphospholipid (aPL) antibodies promote the release of plasma membrane-derived vesicles which inhibit the phagocytosis of apoptotic cells - role in Systemic Lupus Erythematosus (SLE) (135.9)

The Journal of Immunology · 2010