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Emmanuel Addo‐Yobo

Komfo Anokye Teaching Hospital

61 publications · 1,431 citations · ORCID 0000-0003-0038-2531

Asthma and respiratory diseasesPneumonia and Respiratory InfectionsChronic Obstructive Pulmonary Disease (COPD) ResearchInhalation and Respiratory Drug DeliverySchool Health and Nursing Education

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How do specific maternal microbiota profiles (gut, oral, or vaginal) during gestation correlate with the development of gestational diabetes mellitus (GDM) and subsequent long-term metabolic health in offspring?

Why this gap exists: While recent reviews [8] confirm GDM alters maternal gut microbiota and neonatal health, and older studies [0] note dysbiosis across maternal sites, the retrieved evidence lacks direct, longitudinal studies correlating specific gestational maternal microbiota profiles with the *long-term* metabolic health of offspring, leaving the core question unresolved.

To what extent do changes in the maternal microbiota (gut, oral, or vaginal) during pregnancy mediate the relationship between maternal perinatal anxiety/depression and the neurodevelopmental outcomes of the offspring?

Why this gap exists: While recent studies confirm associations between maternal mental health and microbiota composition (Abstract 5, 8) and suggest the microbiome-gut-brain axis influences neurodevelopment (Abstract 0, 2), the retrieved evidence does not contain studies that directly test the mediating role of maternal microbiota changes between perinatal anxiety/depression and offspring neurodevelopmental outcomes.

What are the specific long-term treatment strategies required to mitigate the risk of developing chronic non-communicable diseases in children born to mothers with gestational diabetes mellitus?

Why this gap exists: While the retrieved literature consistently establishes that maternal gestational diabetes mellitus (GDM) increases the long-term risk of cardiometabolic diseases in offspring [1][2][3], it focuses primarily on pathogenesis and risk association rather than defining specific, evidence-based long-term treatment strategies for the children to mitigate these risks.

What are the long-term developmental and health outcomes in children born to mothers who experienced COVID-19-related mental health stressors compared to those who did not, controlling for socioeconomic status?

Why this gap exists: While recent studies [0, 5, 6] link pandemic-related maternal distress to child neurodevelopmental issues, the retrieved evidence focuses on general pandemic exposure rather than specifically isolating COVID-19 mental health stressors while controlling for socioeconomic status, leaving the specific comparison unresolved.

Sources

  1. Disrupted beginnings: Neurodevelopmental outcomes of COVID-19 lockdowns in early childhood (Review).Experimental and therapeutic medicine, 2026
  2. Association of Birth During the COVID-19 Pandemic With Neurodevelopmental Status at 6 Months in Infants With and Without In Utero Exposure to Maternal SARS-CoV-2 InfectionJAMA Pediatrics, 2022
  3. Moms Are Not OK: COVID-19 and Maternal Mental HealthFrontiers in Global Women s Health, 2020
  4. Challenges and burden of the Coronavirus 2019 (COVID-19) pandemic for child and adolescent mental health: a narrative review to highlight clinical and research needs in the acute phase and the long return to normalityChild and Adolescent Psychiatry and Mental Health, 2020
  5. Parenting stress and risk of child maltreatment during the COVID-19 pandemic: A family stress theory-informed perspectiveDevelopmental Child Welfare, 2020
  6. Maternal internalizing symptoms as a mechanism linking pre- and postnatal COVID-19 pandemic exposure with preschool-aged children's neurodevelopment.Archives of women's mental health, 2026
  7. Maternal Distress Due to the COVID-19 Pandemic and Changes in Young Children's Behavior.Journal of developmental and behavioral pediatrics : JDBP, 2026
  8. Impact of the COVID‐19 Pandemic on Parent, Child, and Family FunctioningFamily Process, 2021
  9. Exploring factors influencing mother-infant interaction trajectories post-NICU discharge in low-birth-weight infants during COVID-19 in China: a longitudinal qualitative study.BMC pregnancy and childbirth, 2026
  10. An Efficient Mixture of Deep and Machine Learning Models for COVID-19 and Tuberculosis Detection Using X-Ray Images in Resource Limited SettingsArtificial Intelligence for COVID-19. Studies in Systems, Decision and Control, vol 358. 2021, Springer, Cham, 2020

What is the comparative efficacy of digital versus in-person delivery of mental health interventions for mitigating the increased risk of perinatal depression and anxiety in low-income and middle-income countries during future pandemic-like disruptions?

Why this gap exists: While abstracts [6] and [8] compare digital and in-person delivery during the pandemic, they are set in high-income contexts (Spain, unspecified high-income), and abstract [7] focuses on LMICs but lacks a comparative digital vs. in-person design, leaving the specific question of comparative efficacy in LMICs unresolved.

Sources

  1. Mobile Health for Perinatal Depression and Anxiety: Scoping ReviewJournal of Medical Internet Research, 2020
  2. Effects of COVID-19 on College Students’ Mental Health in the United States: Interview Survey StudyJournal of Medical Internet Research, 2020
  3. A Preventive Social Media Intervention for Perinatal Depression and Anxiety in Regional, Rural, and Remote Communities: Participatory Co-Design Study.Journal of medical Internet research, 2026
  4. Risk-Stratified Screening for Perinatal Depression and Anxiety: Integrating Sexual Function, Self-Esteem, and Psychosocial Context.Diagnostics (Basel, Switzerland), 2026
  5. A Brief Intervention for the Treatment of Anxiety in Pregnancy: A Pilot Randomized Controlled Trial (The TAP Study).Psychotherapy and psychosomatics, 2026
  6. Barriers to and Facilitators of User Engagement With Digital Mental Health Interventions: Systematic ReviewJournal of Medical Internet Research, 2021
  7. Engagement, efficacy, and experiences of psychotherapy for perinatal populations with depression and anxiety during the COVID-19 pandemic.Frontiers in psychiatry, 2025
  8. Integration of stepped care for perinatal mood and anxiety disorders among women attending maternal and child health clinics in Kenya: Protocol for a cluster randomized controlled trial.PloS one, 2026
  9. Internet-based interdisciplinary therapeutic group (Grupo Interdisciplinar Online, GIO) for perinatal anxiety and depression-a randomized pilot study during COVID-19.Archives of women's mental health, 2024
  10. Detecting anxiety and depression in dialogues: a multi-label and explainable approachde Arriba-Pérez, F., García-Méndez, S. (2024). Detecting anxiety and depression in dialogues: a multi-label and explainable approach. In Proceedings of the 3rd AIxIA Workshop on Artificial Intelligence For Healthcare (pp. 257-271), 2024
  11. Community Interventions for Addressing Postpartum Depression Across the United States: A Narrative Review.Cureus, 2026
  12. Perspectives and support needs for a spouse-inclusive digital intervention for perinatal depression and anxiety: a qualitative study.Women's health nursing (Seoul, Korea), 2026
  13. How effective are cognitive behavior therapies for major depression and anxiety disorders? A meta‐analytic update of the evidenceWorld Psychiatry, 2016
  14. Association between maternal and neonatal outcomes and psychosocial risk levels in pregnant women: a convergent parallel mixed methods study protocol.Reproductive health, 2026
  15. Detecting anxiety and depression in dialogues: a multi-label and explainable approachde Arriba-Pérez, F., García-Méndez, S. (2024). Detecting anxiety and depression in dialogues: a multi-label and explainable approach. In Proceedings of the 3rd AIxIA Workshop on Artificial Intelligence For Healthcare (pp. 257-271), 2024
  16. Multitask learning for recognizing stress and depression in social mediaOnline Social Networks and Media (Volumes: 37-38, September 2023), 2023
  17. Digital Cognitive Behavioral Therapy for Insomnia Versus Sleep Hygiene Education for Prevention of Perinatal Depression: Protocol for a Randomized Clinical Trial.JMIR research protocols, 2026

What is the comparative efficacy of household water treatment interventions versus improved water source infrastructure in reducing stunting among children under five in low- and middle-income countries?

Why this gap exists: While the retrieved literature confirms associations between water quality and child growth (e.g., Abstracts 2, 5, 8), no study directly compares the efficacy of household water treatment interventions against improved water source infrastructure for reducing stunting, leaving the specific comparative question unresolved.

Sources

  1. Determinants of stunting in Indonesian children: evidence from a cross-sectional survey indicate a prominent role for the water, sanitation and hygiene sector in stunting reductionBMC Public Health, 2016
  2. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling studyThe Lancet Global Health, 2020
  3. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trialThe Lancet Global Health, 2018
  4. Effects of Water Pollution on Human Health and Disease Heterogeneity: A ReviewFrontiers in Environmental Science, 2022
  5. Associated factors with malnutrition among children under-5 years old in Somaliland: evidence from Somaliland health and demographic survey of 2020.BMC public health, 2026
  6. Safe Drinking Water and Its Impact on Children's Growth and Development: A Systematic Review.International journal of environmental research and public health, 2026
  7. Modelling the impact of dietary diversity on child nutrition in Pakistan: a machine learning analysis with Shapley Additive exPlanations and Boruta interpretability.Journal of global health, 2026
  8. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysisThe Lancet, 2022
  9. Effect of Household Source of Drinking Water on Malnutrition among under Five Children in Ethiopia: Systematic Review and Meta-Analysis2026
  10. Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum FieldsWater 2017, 9, 339, 2018

Publications