Janet Neequaye

University of Ghana

59 publications · 1,192 citations

Lymphoma Diagnosis and TreatmentMalaria Research and ControlViral-associated cancers and disordersMosquito-borne diseases and controlChronic Lymphocytic Leukemia Research

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Janet Neequaye is a clinical researcher and pediatrician whose work has primarily focused on the epidemiology, treatment, and pathogenesis of endemic Burkitt lymphoma (eBL) in Ghana. Neequaye has contributed extensively to understanding the clinical presentation of eBL, the role of malaria and Epstein-Barr virus (EBV) in its etiology, and the management of pediatric infectious diseases including HIV, malaria, and neonatal tetanus.

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What are the specific long-term treatment strategies required to mitigate the risk of developing chronic non-communicable diseases in children born to mothers with gestational diabetes mellitus?

Why this gap exists: While the retrieved literature consistently establishes that maternal gestational diabetes mellitus (GDM) increases the long-term risk of cardiometabolic diseases in offspring [1][2][3], it focuses primarily on pathogenesis and risk association rather than defining specific, evidence-based long-term treatment strategies for the children to mitigate these risks.

Sources

Diagnosis and Classification of Diabetes Mellitus — Diabetes Care, 2010
A Clinical Update on Gestational Diabetes Mellitus — Endocrine Reviews, 2022
Maternal Diabetes and Risk of Early-Onset Cardiovascular Diseases in Offspring. — JAMA cardiology, 2026
Gestational diabetes as an inter-generational cardiometabolic risk factor: spotlight on emerging exerkines. — Cardiovascular diabetology, 2026
Gestational diabetes: from pathogenesis to therapeutic intervention. — Diabetology & metabolic syndrome, 2026
2. Classification and Diagnosis of Diabetes:<i>Standards of Medical Care in Diabetes—2022</i> — Diabetes Care, 2021
Maternal congenital heart disease and risk of child developmental vulnerability in early school age: A population-based cohort study. — PLoS medicine, 2026
Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026
Gestational Diabetes and Obesity: Immediate and Late Sequelae for Offspring. — Children (Basel, Switzerland), 2025
Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications — Diabetes & Metabolism Journal, 2022

What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

New developments in tuberculosis diagnosis and treatment — Breathe, 2022
Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

What is the comparative efficacy and cost-effectiveness of the one-step 75g OGTT versus the two-step (50g GCT followed by 100g OGTT) diagnostic approach in preventing adverse maternal and neonatal outcomes?

Why this gap exists: While Abstract [7] compares diagnostic criteria and Abstract [4] compares 75g and 100g OGTTs, the retrieved evidence lacks direct, comparative studies on the cost-effectiveness and relative efficacy of the one-step versus two-step *approaches* in preventing adverse outcomes, leaving the specific question unresolved.

Sources

Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO Criteria — PLoS ONE, 2016
A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes — New England Journal of Medicine, 2009
Standards of Medical Care in Diabetes—2013 — Diabetes Care, 2012
An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative Review — Diabetes Metabolic Syndrome and Obesity, 2021
Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to detect gestational diabetes mellitus — Frontiers in Endocrinology, 2025
Large language models for generating longitudinal synthetic data in low-risk pregnancy care. — Data in brief, 2026
Effects of physical activity and diet in pregnancy to prevent gestational diabetes: an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation. — Health technology assessment (Winchester, England), 2026
187-OR: Randomized Clinical Trial of the IADPSG vs. Carpenter Coustan Criteria for Diagnosis of Gestational Diabetes Mellitus — Diabetes, 2020
Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A cross-sectional study. — Diabetes & metabolic syndrome, 2019
Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026

How do specific cultural beliefs regarding 'insufficient milk' in rural South African communities mediate the relationship between maternal dietary diversity and the introduction of prelacteal feeds?

Why this gap exists: While the retrieved papers discuss general breastfeeding barriers in South Africa [8] and cultural influences in other regions like Ethiopia [6] and Malaysia [9], none specifically address the mediation of 'insufficient milk' beliefs on the relationship between maternal dietary diversity and prelacteal feeds in rural South African communities.

Sources

African Political Systems. — American Sociological Review, 1940
Maternal nutrition counselling is associated with reduced stunting prevalence and improved feeding practices in early childhood: a post-program comparison study — Nutrition Journal, 2019
Trends and determinants of early initiation of breastfeeding and exclusive breastfeeding in Ethiopia from 2000 to 2016 — International Breastfeeding Journal, 2019
Marketing of commercial milk formula: a system to capture parents, communities, science, and policy — The Lancet, 2023
Facilitators, barriers, and factors determining the willingness to donate human milk among postpartum mothers in a tertiary women's hospital in Nepal: a cross-sectional study. — International breastfeeding journal, 2026
Assessment of Infant and Young Child Feeding Practices among Mothers Attending Maternal and Child Health Clinic at a Tertiary Hospital, North Karnataka, India - A Cross-sectional Study. — Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine, 2025
Sociocultural and structural influences on infant and young child feeding in pastoralist communities of Afar, Ethiopia: a qualitative phenomenological study. — BMJ open, 2026
Knowledge, attitude, and practice of exclusive breastfeeding among mothers in East Africa: a systematic review — International Breastfeeding Journal, 2020
Facilitators and barriers associated with breastfeeding among mothers attending primary healthcare facilities in Mpumalanga, South Africa. — Frontiers in nutrition, 2023
Assessing the Influence of Cultural Beliefs and Practices on Early Breastfeeding Initiation Rates in Rural Sarawak Communities, Malaysia — Scientific Journal of Pediatrics, 2023

How do specific maternal microbiota profiles (gut, oral, or vaginal) during gestation correlate with the development of gestational diabetes mellitus (GDM) and subsequent long-term metabolic health in offspring?

Why this gap exists: While recent reviews [8] confirm GDM alters maternal gut microbiota and neonatal health, and older studies [0] note dysbiosis across maternal sites, the retrieved evidence lacks direct, longitudinal studies correlating specific gestational maternal microbiota profiles with the *long-term* metabolic health of offspring, leaving the core question unresolved.

Sources

Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus — Gut, 2018
Dysbiosis of the gut microbiota in disease — Microbial Ecology in Health and Disease, 2015
Temporal development of the gut microbiome in early childhood from the TEDDY study — Nature, 2018
Microbiota in health and diseases — Signal Transduction and Targeted Therapy, 2022
Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis — Hormone and Metabolic Research, 2024
Perinatal phlorizin alleviates maternal high-fat diet-induced metabolic syndrome in female mouse offspring and is associated with modulation of the gut microbiota. — Frontiers in nutrition, 2026
Offspring long-term infectious morbidity following pregnancies with cervical cerclage. — Archives of gynecology and obstetrics, 2026
Interaction between microbiota and immunity in health and disease — Cell Research, 2020
Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions. — Journal of translational medicine, 2026
Microbes in the Moonlight: How the Gut Microbiota Influences Sleep — arXiv preprint, 2025

To what extent does maternal access to improved water and sanitation facilities mediate the relationship between maternal undernutrition and child developmental outcomes during the first 1,000 days?

Why this gap exists: While the retrieved papers confirm the individual importance of WASH access for child nutrition [0], maternal undernutrition for child development [5, 8], and the critical nature of the first 1,000 days [5], none of the provided abstracts directly analyze the specific mediating role of water and sanitation facilities in the relationship between maternal undernutrition and child developmental outcomes.

Sources

Household water, sanitation, and hygiene access and its impact on nutritional outcomes in children under five: evidence from Pakistan. — BMC public health, 2026
Early childhood development and stunting: Findings from the MAL‐ED birth cohort study in Bangladesh — Maternal and Child Nutrition, 2019
Policy and Structural Drivers of Malnutrition in Afghan Women: Evidence and Interventions. — International journal of women's health, 2026
COVID-19 pandemic and mitigation strategies: implications for maternal and child health and nutrition — American Journal of Clinical Nutrition, 2020
Maternal and child undernutrition 3: what works? Interventions for maternal and child undernutrition and survival — Child: Care, Health and Development, 2008
Nutrition as the Foundation of Human Capital: Pathways to Holistic Development. — Maternal & child nutrition, 2026
The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring. — The British journal of nutrition, 2017
Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
Prevalence of undernutrition and its associated factors among pregnant women attending antenatal care service in public hospitals in Mogadishu, Somalia. — PloS one, 2026
Concurrent wasting and stunting among under‐five children in Niakhar, Senegal — Maternal & Child Nutrition, 2018

Publications

Subtyping Burkitt Lymphoma by <scp>DNA</scp> Methylation

Genes Chromosomes and Cancer · 2025 · 9 citations

Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

EBioMedicine · 2018 · 25 citations

The changing clinical pattern of endemic Burkitt lymphoma in Western Africa: Experience from a tertiary center in Ghana

Pediatric Blood & Cancer · 2018 · 14 citations

Frequency of EBV LMP-1 Promoter and Coding Variations in Burkitt Lymphoma Samples in Africa and South America and Peripheral Blood in Uganda

Cancers · 2018 · 12 citations

High-throughput sequencing of the B-cell receptor in African Burkitt lymphoma reveals clues to pathogenesis

Blood Advances · 2017 · 29 citations

High-throughput sequencing reveals novel features of immunoglobulin gene rearrangements in Burkitt lymphoma

Blood Advances · 2017 · 1 citations

PROFILING OF DNA METHYLATION IN EPIDEMIOLOGICAL AND CLINICAL SUBGROUPS OF BURKITT LYMPHOMA IN THE FRAMEWORK OF THE MMML: ICGC AND BLUEPRINT CONSORTIA

Hematological Oncology · 2017

Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration

International Journal of Cancer · 2016 · 19 citations

Epstein-Barr virus from Burkitt Lymphoma biopsies from Africa and South America share novel LMP-1 promoter and gene variations

Scientific Reports · 2015 · 31 citations

Human Immune Deficiency Virus Infections in Ghana

2015 · 1 citations

Childhood Burkitt lymphoma in Ghana: A retrospective study from the pediatric oncology unit of Korle Bu Teaching Hospital, Accra

PubMed Central · 2015

Elevated serum levels of interleukin‐6 in endemic Burkitt lymphoma in Ghana

Hematological Oncology · 2014 · 4 citations

Endomyocardial fibrosis associated with Schistosoma haematobium infection.

PubMed · 2014 · 3 citations

Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response

Blood · 2013 · 37 citations

Risk of Burkitt Lymphoma Correlates with Breadth and Strength of Antibody Response to Plasmodium Falciparum Malaria Stage-Specific Antigens

Blood · 2012 · corresponding author

African Burkitt Lymphoma: Age-Specific Risk and Correlations with Malaria Biomarkers

American Journal of Tropical Medicine and Hygiene · 2011 · 43 citations

Kawasaki disease in Ghana: Case reports from Korle Bu Teaching Hospital

Ghana Medical Journal · 2011 · 15 citations

Antibodies reactive to <i>Plasmodium falciparum</i> serine repeat antigen in children with Burkitt lymphoma from Ghana

International Journal of Cancer · 2011 · 11 citations

Osteomyelitis of the frontal bone

Ghana Medical Journal · 2010 · 24 citations

Comparison of chloroquine with Quinimax(R) in the treatment of cerebral malaria in Ghanaian children

Research at the University of Copenhagen (University of Copenhagen) · 2003

Complement binding to erythrocytes is associated with macrophage activation and reduced haemoglobin in Plasmodium falciparum malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene · 2001 · 49 citations

Oral Chloroquine in the treatment of cerebral malaria in Ghanaian Children

Research at the University of Copenhagen (University of Copenhagen) · 2000 · 1 citations

Congenital rubella syndrome in Korle Bu Teaching Hospital

2000

HIV-1 and HIV-2 in Ghana, west Africa: community surveys compared to surveys of pregnant women.

PubMed · 1997 · 10 citations

Will Genetic Counselling Be Effective in Controlling Sickle Cell Disease in Ghana

1995

Acute Hepatitis in Recurrent Hereditary Polyserositis (Familial Mediterranean Fever)

Journal of Tropical Pediatrics · 1994 · 17 citations

The Prevalence of Antibodies to the Human T Lymphotropic Virus (HTLV) in Ghana, West Africa

AIDS Research and Human Retroviruses · 1993 · 23 citations

Geographic/Ethnic Differences in Human Herpesvirus‐6 Antibody Patterns

Microbiology and Immunology · 1992 · 18 citations

Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma [see comments]

Blood · 1991 · 207 citations

Factors That Could Influence the Spread of AIDS in Ghana, West Africa

JAIDS Journal of Acquired Immune Deficiency Syndromes · 1991 · 52 citations

Sero‐epidemiological investigations on human herpesvirus 6 (HHV‐6) infections using a newly developed early antigen assay

International Journal of Cancer · 1991 · 47 citations

Characterization and localization of Plasmodium falciparum surface antigens on infected erythrocytes from west African patients

Blood · 1991 · 38 citations

Comparative trial of oral versus intramuscular chloroquine in children with cerebral malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene · 1991 · 17 citations

Menarche and reproduction after treatment for African Burkitt's lymphoma.

BMJ · 1991 · 7 citations

Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma [see comments]

Blood · 1991 · 4 citations

Genes for Plasmodium falciparum surface antigens cloned by expression in COS cells.

Proceedings of the National Academy of Sciences · 1990 · 66 citations

Specific transfer factor with activity against Epstein-Barr virus reduces late relapse in endemic Burkitt's lymphoma.

PubMed · 1990 · 23 citations

Human Immunodeficiency Virus (HIV) infection following transfusion of screened blood in Accra, Ghana.

1990 · 1 citations

Malaria chemoprophylaxis -a paediatrician's view point

1989 · corresponding author

Two approximately 300 kilodalton Plasmodium falciparum proteins at the surface membrane of infected erythrocytes

Molecular and Biochemical Parasitology · 1988 · 127 citations

Falciparum Malaria not sensitive to Chloroquine Emerges in Accra in 1987.

1988 · 14 citations

Cardiotoxic effects of milk bush - A common herbal remedy: A report of two cases

1988 · corresponding author

A Review of Paediatric Aids

1988

Ghanaian children of women infected with human immuno- deficiency virus (HIV).

1988

A report on Human Immuno- deficiency virus (HIV) Infection in Ghana up to December 1986

1987 · 2 citations

Ebv-Specific Transfer Factor in the Treatment of Abdominal Burkitt’s Lymphoma in Ghana, West Africa

Humana Press eBooks · 1987

In vivo chloroquine-resistant falciparum malaria in western Africa.

PubMed · 1986 · 53 citations

IN VIVO CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN WESTERN AFRICA

The Lancet · 1986 · 40 citations

PREPONDERANCE OF FEMALES WITH AIDS IN GHANA

The Lancet · 1986 · 23 citations

Intrathecal chemoprophylaxis in the prevention of central nervous system relapse in Burkitt's lymphoma

Cancer · 1985 · 17 citations

EBV-Specific Transfer Factor in the Treatment Of African Burkitt’s Lymphoma: A Pilot Study

1985

Bone marrow in sickle cell anaemia at time of anaemic crisis.

Archives of Disease in Childhood · 1984 · 12 citations

NEONATAL TETANUS IN ACCRA

The Lancet · 1984 · corresponding author

Failure of intrathecal antitetanus serum to improve survival in neonatal tetanus.

Archives of Disease in Childhood · 1983 · 24 citations

Use of buffy-coat smears in the diagnosis of septicaemia in children

Annals of Tropical Paediatrics · 1983

AGE AND SEX AS FACTORS INFLUENCING REMISSION DURATION IN AFRICAN BURKITTS LYMPHOMA

American Journal of Epidemiology · 1982 · 4 citations

Cerebrospinal Fluid Markers in African Burkitt's Lymphoma WithCentral Nervous System Involvement<xref ref-type="fn" rid="FN2">2</xref>

JNCI Journal of the National Cancer Institute · 1982 · 1 citations

Changes in presenting tumour site of Burkitt's lymphoma in Ghana, West Africa, 1965-1978

British Journal of Cancer · 1981 · 17 citations

A review of salmonella group G septicaemia in children at the korle bu teaching hospital (1973-1978).

1980