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Fred Stephen Sarfo

Komfo Anokye Teaching Hospital

423 publications · 10,285 citations · ORCID 0000-0001-7274-5093

Acute Ischemic Stroke ManagementStroke Rehabilitation and RecoveryBlood Pressure and Hypertension StudiesMycobacterium research and diagnosisHIV-related health complications and treatments

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Fred Stephen Sarfo is a neurologist and researcher focused on the epidemiology, prevention, and management of stroke and other non-communicable diseases in sub-Saharan Africa. Sarfo leads large-scale multicenter studies such as the Stroke Investigative Research and Educational Network (SIREN) and clinical trials like SMAART and PINGS to investigate stroke risk factors, genetics, and secondary prevention strategies in Ghana and Nigeria. Additionally, Sarfo contributes to research on sickle cell disease, HIV-associated co-infections, and the implementation of digital health technologies for neurological care.

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What is the comparative effectiveness of telemedicine versus traditional in-person care in maintaining essential antenatal coverage and reducing maternal mortality in low-income and middle-income countries during future health system shocks?

Why this gap exists: While abstracts [4], [7], [8], and [9] discuss digital tools and maternity care in low- and middle-income countries, none provide a direct comparative effectiveness analysis of telemedicine versus in-person care regarding maternal mortality during health system shocks, leaving the specific question unresolved.

Sources

  1. COVID-19 and resilience of healthcare systems in ten countriesNature Medicine, 2022
  2. Community Health Workers Can Provide Psychosocial Support to the People During COVID-19 and Beyond in Low- and Middle- Income CountriesFrontiers in Public Health, 2021
  3. Social Impacts and Responses Related to COVID-19 in Low- and Middle-income CountriesOpenDocs (Institute of Development Studies), 2020
  4. Seizing the moment to rethink health systemsThe Lancet Global Health, 2021
  5. Use of mHealth in promoting maternal and child health in “BIMARU” states of India “A health system strengthening strategy”: Systematic literature reviewPLOS Digital Health, 2024
  6. Investments for effective functionality of health systems towards Universal Health Coverage in Africa: A scoping reviewPLOS Global Public Health, 2022
  7. Infant and young child feedingOECD eBooks, 2023
  8. Facilitators and barriers to the implementation of a Mobile Health Wallet for pregnancy-related health care: A qualitative study of stakeholders’ perceptions in MadagascarPLoS ONE, 2020
  9. The impact of digital interventions on health insurance coverage for reproductive, maternal, newborn and child health services utilization in Kakamega, Kenya: a cluster randomized controlled trialHealth Policy and Planning, 2024
  10. Seeking digital maternity healthcare during the pandemic health system shock: a systematic review of women's experiences in low- and middle-income countriesFrontiers in Reproductive Health, 2026

How do specific policy interventions aimed at improving female education and labor force participation accelerate the 'maternal mortality transition' in regions currently experiencing high maternal mortality?

Why this gap exists: While the retrieved literature establishes links between female education, political power, and health outcomes (e.g., [3], [6], [9]), no study directly addresses how specific labor or education policy interventions accelerate the 'maternal mortality transition' in high-mortality regions, leaving the mechanism and impact of such specific policies unresolved.

How does the consumption of plant-based proteins, specifically those high in anti-nutritional factors like phytates and trypsin inhibitors, affect mineral bioavailability and growth outcomes in children relying on these proteins as primary staples?

Why this gap exists: While the retrieved papers confirm that anti-nutritional factors like phytates and trypsin inhibitors reduce mineral bioavailability [0, 2], they focus on general adult health or crop improvement [1, 6] and do not provide direct evidence on the specific growth outcomes in children relying on these proteins as primary staples.

Publications

Role of Nutritional Epigenetics for Cerebrovascular Health in Low‐ and Middle‐Income Countries

Journal of the American Heart Association · 2025 · corresponding author · 4 citations

Time delays in emergency stroke care in a low-resource referral hospital in Ghana

African Journal of Emergency Medicine · 2025 · 4 citations

Costs analysis of integrating group interpersonal therapy into HIV care services in Senegal

International Journal of Mental Health Systems · 2025 · 1 citations

Burden of perceived stress among stroke survivors in Ghana: Insights from a multicentre, cross-sectional study

Journal of Stroke and Cerebrovascular Diseases · 2025 · corresponding author · 1 citations

Advancing Cardiovascular Health Equity Globally Through Digital Technologies

Journal of the American Heart Association · 2024 · 11 citations

Stroke occurrence by hypertension treatment status in Ghana and Nigeria: A case-control study

Journal of the Neurological Sciences · 2024 · corresponding author · 5 citations

Epigenetics as a target to mitigate excess stroke risk in people of African ancestry: A scoping review

Journal of Stroke and Cerebrovascular Diseases · 2024 · corresponding author · 1 citations

Table of Contents

Journal of Stroke and Cerebrovascular Diseases · 2024

Determinants of First‐Ever Stroke Severity in West Africans: Evidence From the SIREN Study

Journal of the American Heart Association · 2023 · 8 citations

Risk factors and outcomes of delirium in hospitalized older Ghanaians

International Journal of Geriatric Psychiatry · 2023 · 5 citations

Frequency & factors associated with elevated lipoprotein-a among Ghanaian stroke survivors

Journal of the Neurological Sciences · 2023 · corresponding author · 1 citations

PREVALENCE AND RISK FACTORS OF STROKE RECURRENCE IN GHANA AND NIGERIA

Journal of Stroke and Cerebrovascular Diseases · 2023 · 1 citations

Table of Contents

Journal of Stroke and Cerebrovascular Diseases · 2023

Utilizing Implementation Science to Bridge Cerebrovascular Health Disparities: a Local to Global Perspective

Current Neurology and Neuroscience Reports · 2022 · corresponding author · 14 citations

Feasibility, acceptability, and appropriateness of a mobile health stroke intervention among Ghanaian health workers

Journal of the Neurological Sciences · 2022 · corresponding author · 12 citations

Long-term determinants of death after stroke in Ghana: Analysis by stroke types & subtypes

Journal of Stroke and Cerebrovascular Diseases · 2022 · corresponding author · 11 citations

Life's Simple 7 at Midlife and Risk of Recurrent Cardiovascular Disease and Mortality after Stroke: The ARIC study

Journal of Stroke and Cerebrovascular Diseases · 2022 · corresponding author · 10 citations

Frequency & factors associated with recurrent stroke in Ghana and Nigeria

Journal of the Neurological Sciences · 2022 · 10 citations

Carers’ needs assessment for patients with dementia in Ghana

African Journal of Primary Health Care & Family Medicine · 2022 · 8 citations

Nationwide rates of outpatient clinic attendance by stroke survivors in Ghana: Analysis by region and facility

Journal of the Neurological Sciences · 2022 · corresponding author · 4 citations

Promise of Physiological Profiling to Prevent Stroke in People of African Ancestry: Prototyping Ghana

Current Neurology and Neuroscience Reports · 2022 · corresponding author · 3 citations

Human Rights Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa

International Human Rights Law Review · 2022 · 1 citations

Differential associations between pre-diabetes, diabetes and stroke occurrence among West Africans

Journal of Stroke and Cerebrovascular Diseases · 2022 · 1 citations

Table of Contents

Journal of Stroke and Cerebrovascular Diseases · 2022

Stroke in Africa: profile, progress, prospects and priorities

Nature Reviews Neurology · 2021 · 316 citations

A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study

Journal of Stroke and Cerebrovascular Diseases · 2021 · 18 citations

Frequency and factors associated with post-stroke seizures in a large multicenter study in West Africa

Journal of the Neurological Sciences · 2021 · corresponding author · 14 citations

Key determinants of long-term post-stroke mortality in Ghana

Journal of the Neurological Sciences · 2021 · corresponding author · 12 citations

Contemporary trends in HIV-associated neurocognitive disorders in Ghana

Clinical Neurology and Neurosurgery · 2021 · corresponding author · 11 citations

Influence of age on links between major modifiable risk factors and stroke occurrence in West Africa

Journal of the Neurological Sciences · 2021 · corresponding author · 9 citations

Quantitative and qualitative analyses of herbal medication use among Ghanaian stroke survivors

Journal of the Neurological Sciences · 2021 · corresponding author · 8 citations

High frequency of post-stroke seizures among West Africans

Journal of the Neurological Sciences · 2021