Global Maternal and Child HealthAdolescent Sexual and Reproductive HealthReproductive Health and ContraceptionBreastfeeding Practices and InfluencesReproductive Health and Technologies
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How do specific maternal microbiota profiles (gut, oral, or vaginal) during gestation correlate with the development of gestational diabetes mellitus (GDM) and subsequent long-term metabolic health in offspring?
Why this gap exists: While recent reviews [8] confirm GDM alters maternal gut microbiota and neonatal health, and older studies [0] note dysbiosis across maternal sites, the retrieved evidence lacks direct, longitudinal studies correlating specific gestational maternal microbiota profiles with the *long-term* metabolic health of offspring, leaving the core question unresolved.
Microbes in the Moonlight: How the Gut Microbiota Influences Sleep — arXiv preprint, 2025
To what extent do changes in the maternal microbiota (gut, oral, or vaginal) during pregnancy mediate the relationship between maternal perinatal anxiety/depression and the neurodevelopmental outcomes of the offspring?
Why this gap exists: While recent studies confirm associations between maternal mental health and microbiota composition (Abstract 5, 8) and suggest the microbiome-gut-brain axis influences neurodevelopment (Abstract 0, 2), the retrieved evidence does not contain studies that directly test the mediating role of maternal microbiota changes between perinatal anxiety/depression and offspring neurodevelopmental outcomes.
What is the comparative efficacy of digital or telehealth lactation support versus traditional face-to-face peer support on breastfeeding exclusivity rates during pandemic-related social restrictions?
Why this gap exists: While Abstract [3] confirms the general effectiveness of digital health interventions on breastfeeding practices and Abstract [0] notes the cancellation of face-to-face peer support during the pandemic, the retrieved evidence does not contain a direct comparative study between digital/telehealth lactation support and traditional face-to-face peer support specifically regarding exclusivity rates during social restrictions.
How do specific cultural beliefs regarding 'insufficient milk' in rural South African communities mediate the relationship between maternal dietary diversity and the introduction of prelacteal feeds?
Why this gap exists: While the retrieved papers discuss general breastfeeding barriers in South Africa [8] and cultural influences in other regions like Ethiopia [6] and Malaysia [9], none specifically address the mediation of 'insufficient milk' beliefs on the relationship between maternal dietary diversity and prelacteal feeds in rural South African communities.
How do specific policy interventions aimed at improving female education and labor force participation accelerate the 'maternal mortality transition' in regions currently experiencing high maternal mortality?
Why this gap exists: While the retrieved literature establishes links between female education, political power, and health outcomes (e.g., [3], [6], [9]), no study directly addresses how specific labor or education policy interventions accelerate the 'maternal mortality transition' in high-mortality regions, leaving the mechanism and impact of such specific policies unresolved.
How does the longitudinal trajectory of maternal stress and resilience during pregnancy specifically mediate the association between social determinants of health (e.g., socioeconomic status, structural inequality) and infant cognitive or emotional development outcomes?
Why this gap exists: While the retrieved literature confirms associations between socioeconomic disadvantage, maternal stress, and infant neurodevelopment, it does not resolve the specific question of how longitudinal trajectories of maternal stress and resilience mediate these associations, as the studies focus on broad correlations or static measures rather than dynamic mediation pathways.
Chronic stress may disrupt covariant fluctuations of vitamin D and cortisol plasma levels in pregnant sheep during the last trimester: a preliminary report — arXiv preprint, 2019