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Albert Akpalu

University of Ghana

219 publications · 5,937 citations · ORCID 0000-0002-4802-9852

Acute Ischemic Stroke ManagementStroke Rehabilitation and RecoveryDementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsEpilepsy research and treatment

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How does the longitudinal trajectory of maternal stress and resilience during pregnancy specifically mediate the association between social determinants of health (e.g., socioeconomic status, structural inequality) and infant cognitive or emotional development outcomes?

Why this gap exists: While the retrieved literature confirms associations between socioeconomic disadvantage, maternal stress, and infant neurodevelopment, it does not resolve the specific question of how longitudinal trajectories of maternal stress and resilience mediate these associations, as the studies focus on broad correlations or static measures rather than dynamic mediation pathways.

What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

How do specific policy interventions aimed at improving female education and labor force participation accelerate the 'maternal mortality transition' in regions currently experiencing high maternal mortality?

Why this gap exists: While the retrieved literature establishes links between female education, political power, and health outcomes (e.g., [3], [6], [9]), no study directly addresses how specific labor or education policy interventions accelerate the 'maternal mortality transition' in high-mortality regions, leaving the mechanism and impact of such specific policies unresolved.

What is the comparative effectiveness of telemedicine versus traditional in-person care in maintaining essential antenatal coverage and reducing maternal mortality in low-income and middle-income countries during future health system shocks?

Why this gap exists: While abstracts [4], [7], [8], and [9] discuss digital tools and maternity care in low- and middle-income countries, none provide a direct comparative effectiveness analysis of telemedicine versus in-person care regarding maternal mortality during health system shocks, leaving the specific question unresolved.

Sources

  1. COVID-19 and resilience of healthcare systems in ten countriesNature Medicine, 2022
  2. Community Health Workers Can Provide Psychosocial Support to the People During COVID-19 and Beyond in Low- and Middle- Income CountriesFrontiers in Public Health, 2021
  3. Social Impacts and Responses Related to COVID-19 in Low- and Middle-income CountriesOpenDocs (Institute of Development Studies), 2020
  4. Seizing the moment to rethink health systemsThe Lancet Global Health, 2021
  5. Use of mHealth in promoting maternal and child health in “BIMARU” states of India “A health system strengthening strategy”: Systematic literature reviewPLOS Digital Health, 2024
  6. Investments for effective functionality of health systems towards Universal Health Coverage in Africa: A scoping reviewPLOS Global Public Health, 2022
  7. Infant and young child feedingOECD eBooks, 2023
  8. Facilitators and barriers to the implementation of a Mobile Health Wallet for pregnancy-related health care: A qualitative study of stakeholders’ perceptions in MadagascarPLoS ONE, 2020
  9. The impact of digital interventions on health insurance coverage for reproductive, maternal, newborn and child health services utilization in Kakamega, Kenya: a cluster randomized controlled trialHealth Policy and Planning, 2024
  10. Seeking digital maternity healthcare during the pandemic health system shock: a systematic review of women's experiences in low- and middle-income countriesFrontiers in Reproductive Health, 2026

How does the consumption of plant-based proteins, specifically those high in anti-nutritional factors like phytates and trypsin inhibitors, affect mineral bioavailability and growth outcomes in children relying on these proteins as primary staples?

Why this gap exists: While the retrieved papers confirm that anti-nutritional factors like phytates and trypsin inhibitors reduce mineral bioavailability [0, 2], they focus on general adult health or crop improvement [1, 6] and do not provide direct evidence on the specific growth outcomes in children relying on these proteins as primary staples.

Publications

Low-density lipoprotein cholesterol and severity of intracerebral hemorrhage: Insights from the SIREN study

Journal of the Neurological Sciences · 2025 · corresponding author · 1 citations

Determinants of First‐Ever Stroke Severity in West Africans: Evidence From the SIREN Study

Journal of the American Heart Association · 2023 · 8 citations

PREVALENCE AND RISK FACTORS OF STROKE RECURRENCE IN GHANA AND NIGERIA

Journal of Stroke and Cerebrovascular Diseases · 2023 · 1 citations

Intracranial aneurysms in Ghanaian adults

Ghana Medical Journal · 2023 · 1 citations

Frequency & factors associated with recurrent stroke in Ghana and Nigeria

Journal of the Neurological Sciences · 2022 · 10 citations

Developing stroke care services in west Africa

The Lancet Neurology · 2022 · 2 citations

Differential associations between pre-diabetes, diabetes and stroke occurrence among West Africans

Journal of Stroke and Cerebrovascular Diseases · 2022 · 1 citations

Human Rights Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa

International Human Rights Law Review · 2022 · 1 citations

Exercise Induced Paralysis in Two Young Ghanaian Men

Postgraduate Medical Journal of Ghana · 2022

The International Parkinson Disease Genomics Consortium Africa

The Lancet Neurology · 2021 · 27 citations

A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study

Journal of Stroke and Cerebrovascular Diseases · 2021 · 18 citations

Conceptual framework for establishing the African Stroke Organization

International Journal of Stroke · 2020 · 30 citations

Antecedent febrile illness and occurrence of stroke in West Africa: The SIREN study

Journal of the Neurological Sciences · 2020 · 4 citations

Stroke Among Young West Africans

Stroke · 2018 · 155 citations

APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke

Acta Neurologica Scandinavica · 2017 · 38 citations

Stroke Investigative Research and Education Network: Public Outreach and Engagement

Journal of Community Medicine & Health Education · 2017 · 18 citations

Joan Agama Dellor 1977–2014

Lara D. Veeken · 2017

Use of Mosquito Nets: Is it Time to Think Differently?

Spiral (Imperial College London) · 2017

Stroke Investigative Research and Education Network

Health Education & Behavior · 2016 · 26 citations

The burden of stroke in Africa: a glance at the present and a glimpse into the future: review article

Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · 2015 · 414 citations

Stroke genomics in people of African ancestry: charting new paths: review article

Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · 2015 · 39 citations

The medical system in Ghana.

PubMed · 2014 · 36 citations

Food Preservation, Snake Venoms and Stroke in the Tropics

2014 · corresponding author · 2 citations

Beliefs on epilepsy in Northern Ghana

Epilepsy & Behavior · 2013 · 37 citations