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Dorothy Yeboah‐Manu

University of Ghana

227 publications · 8,284 citations · ORCID 0000-0002-1663-6287

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosisDiagnosis and treatment of tuberculosisInfectious Diseases and TuberculosisInfectious Diseases and Mycology

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What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

How does the longitudinal trajectory of maternal stress and resilience during pregnancy specifically mediate the association between social determinants of health (e.g., socioeconomic status, structural inequality) and infant cognitive or emotional development outcomes?

Why this gap exists: While the retrieved literature confirms associations between socioeconomic disadvantage, maternal stress, and infant neurodevelopment, it does not resolve the specific question of how longitudinal trajectories of maternal stress and resilience mediate these associations, as the studies focus on broad correlations or static measures rather than dynamic mediation pathways.

What is the comparative effectiveness of telemedicine versus traditional in-person care in maintaining essential antenatal coverage and reducing maternal mortality in low-income and middle-income countries during future health system shocks?

Why this gap exists: While abstracts [4], [7], [8], and [9] discuss digital tools and maternity care in low- and middle-income countries, none provide a direct comparative effectiveness analysis of telemedicine versus in-person care regarding maternal mortality during health system shocks, leaving the specific question unresolved.

Sources

  1. COVID-19 and resilience of healthcare systems in ten countriesNature Medicine, 2022
  2. Community Health Workers Can Provide Psychosocial Support to the People During COVID-19 and Beyond in Low- and Middle- Income CountriesFrontiers in Public Health, 2021
  3. Social Impacts and Responses Related to COVID-19 in Low- and Middle-income CountriesOpenDocs (Institute of Development Studies), 2020
  4. Seizing the moment to rethink health systemsThe Lancet Global Health, 2021
  5. Use of mHealth in promoting maternal and child health in “BIMARU” states of India “A health system strengthening strategy”: Systematic literature reviewPLOS Digital Health, 2024
  6. Investments for effective functionality of health systems towards Universal Health Coverage in Africa: A scoping reviewPLOS Global Public Health, 2022
  7. Infant and young child feedingOECD eBooks, 2023
  8. Facilitators and barriers to the implementation of a Mobile Health Wallet for pregnancy-related health care: A qualitative study of stakeholders’ perceptions in MadagascarPLoS ONE, 2020
  9. The impact of digital interventions on health insurance coverage for reproductive, maternal, newborn and child health services utilization in Kakamega, Kenya: a cluster randomized controlled trialHealth Policy and Planning, 2024
  10. Seeking digital maternity healthcare during the pandemic health system shock: a systematic review of women's experiences in low- and middle-income countriesFrontiers in Reproductive Health, 2026

How does the consumption of plant-based proteins, specifically those high in anti-nutritional factors like phytates and trypsin inhibitors, affect mineral bioavailability and growth outcomes in children relying on these proteins as primary staples?

Why this gap exists: While the retrieved papers confirm that anti-nutritional factors like phytates and trypsin inhibitors reduce mineral bioavailability [0, 2], they focus on general adult health or crop improvement [1, 6] and do not provide direct evidence on the specific growth outcomes in children relying on these proteins as primary staples.

How do specific policy interventions aimed at improving female education and labor force participation accelerate the 'maternal mortality transition' in regions currently experiencing high maternal mortality?

Why this gap exists: While the retrieved literature establishes links between female education, political power, and health outcomes (e.g., [3], [6], [9]), no study directly addresses how specific labor or education policy interventions accelerate the 'maternal mortality transition' in high-mortality regions, leaving the mechanism and impact of such specific policies unresolved.

Publications

Rebuilding community trust after attacks on Ebola treatment facilities in DRC: lessons from previous epidemics

International Journal of Infectious Diseases · 2026 · corresponding author · 5 citations

Characterizing trachoma elimination using serology

Nature Communications · 2025 · 9 citations

Malaria resurgence in Africa: confronting the challenges

The Lancet Infectious Diseases · 2025 · 3 citations

Data Resource Profile: Global Trachoma Serology Data Repository

International Journal of Epidemiology · 2025 · 2 citations

The epidemiology of Lassa fever in Ghana: A study on the 2023 Lassa fever outbreak in Ghana

Journal of Interventional Epidemiology and Public Health · 2025

Marburg Virus Disease in Ghana

New England Journal of Medicine · 2023 · 14 citations

Macrophage susceptibility to infection by Ghanaian Mycobacterium tuberculosis complex lineages 4 and 5 varies with self-reported ethnicity

Frontiers in Cellular and Infection Microbiology · 2023 · corresponding author · 12 citations

From research to health policy: The Noguchi story in the past, present and next 25 years

Frontiers in Tropical Diseases · 2023 · corresponding author · 2 citations

Diarrhea-Causing Bacteria and Their Antibiotic Resistance Patterns Among Diarrhea Patients From Ghana

Frontiers in Microbiology · 2022 · corresponding author · 30 citations

Drug discovery research in Ghana, challenges, current efforts, and the way forward

PLoS neglected tropical diseases · 2022 · 16 citations

Relevance of genomic diversity of Mycobacterium tuberculosis complex in Africa

International Journal of Infectious Diseases · 2022 · corresponding author · 6 citations

Additional files for BuruliRifDACC

Zenodo (CERN European Organization for Nuclear Research) · 2022 · 6 citations

Zoonotic Tuberculosis – The Changing Landscape

International Journal of Infectious Diseases · 2021 · corresponding author · 103 citations

Minimizing the impact of the triple burden of COVID-19, tuberculosis and HIV on health services in sub-Saharan Africa

International Journal of Infectious Diseases · 2021 · corresponding author · 79 citations

Diagnosis of tuberculosis among COVID-19 suspected cases in Ghana

PLoS ONE · 2021 · corresponding author · 16 citations

The Relevance of Genomic Epidemiology for Control of Tuberculosis in West Africa

Frontiers in Public Health · 2021 · corresponding author · 11 citations

Bacterial Load Comparison of the Three Main Lineages of Mycobacterium tuberculosis Complex in West Africa

Frontiers in Microbiology · 2021 · corresponding author · 7 citations

Molecular epidemiology and drug susceptibility profiles of Mycobacterium tuberculosis complex isolates from Northern Ghana

International Journal of Infectious Diseases · 2021 · corresponding author · 7 citations

Primary Isolation of Mycobacterium ulcerans

Methods in molecular biology · 2021 · corresponding author · 3 citations

COVID-19—Zoonosis or Emerging Infectious Disease?

Frontiers in Public Health · 2020 · 188 citations

Non-tuberculous mycobacterial infections—A neglected and emerging problem

International Journal of Infectious Diseases · 2020 · 97 citations

Zoonotic tuberculosis—a call for an open One Health debate

The Lancet Infectious Diseases · 2020 · 17 citations

Commemorating World TB Day 2020: “IT’S TIME” — It’s time to End the Global TB Epidemic

International Journal of Infectious Diseases · 2020 · corresponding author · 13 citations

Latent TB Infection (LTBI) – Mycobacterium tuberculosis pathogenesis and the dynamics of the granuloma battleground

International Journal of Infectious Diseases · 2019 · corresponding author · 53 citations

Improving treatment outcomes for MDR-TB — Novel host-directed therapies and personalised medicine of the future

International Journal of Infectious Diseases · 2019 · corresponding author · 36 citations

Challenges of bovine tuberculosis control and genetic distribution in Africa

Biomedical and Biotechnology Research Journal (BBRJ) · 2019 · 16 citations

Secondary Infection of Buruli Ulcer Lesions

2019 · corresponding author · 8 citations

Bovine Tuberculosis in Ghana

2019 · 2 citations

Buruli Ulcer: a Review of the Current Knowledge

Current Tropical Medicine Reports · 2018 · 117 citations

Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africa

International Journal of Infectious Diseases · 2018 · corresponding author · 42 citations

Laboratory confirmation of Buruli ulcer cases in Ghana, 2008-2016

PLoS neglected tropical diseases · 2018 · 25 citations

Challenges associated with the treatment of Buruli ulcer

Journal of Leukocyte Biology · 2018 · corresponding author · 15 citations

OMNIgene SPUTUM: A good transport and decontaminating reagent for tuberculosis testing

International Journal of Mycobacteriology · 2018 · corresponding author · 9 citations

Molecular epidemiology and whole genome sequencing analysis of clinical Mycobacterium bovis from Ghana

bioRxiv (Cold Spring Harbor Laboratory) · 2018 · corresponding author · 5 citations

The global dynamics of diabetes and tuberculosis: the impact of migration and policy implications

International Journal of Infectious Diseases · 2017 · 64 citations

The Biology and Epidemiology of Mycobacterium africanum

Advances in experimental medicine and biology · 2017 · corresponding author · 25 citations

Longitudinal assessment of the bacterial burden of buruli ulcer wounds during treatment

Biomedical and Biotechnology Research Journal (BBRJ) · 2017 · corresponding author · 8 citations

Antimycobacterial and cytotoxic activity of selected medicinal plant extracts

Journal of Ethnopharmacology · 2016 · 89 citations

Spatio-Temporal Distribution of Mycobacterium tuberculosis Complex Strains in Ghana

PLoS ONE · 2016 · corresponding author · 53 citations

Molecular epidemiology of Mycobacterium africanum in Ghana

BMC Infectious Diseases · 2016 · corresponding author · 50 citations

Clinical and Laboratory Diagnosis of Buruli Ulcer Disease: A Systematic Review

Canadian Journal of Infectious Diseases and Medical Microbiology · 2016 · 44 citations

Taking forward the World TB Day 2016 theme ‘Unite to End Tuberculosis’ for the WHO Africa Region

International Journal of Infectious Diseases · 2016 · 25 citations

Burden and Historical Trend of Buruli Ulcer Prevalence in Selected Communities along the Offin River of Ghana

PLoS neglected tropical diseases · 2016 · corresponding author · 23 citations

A Sero-epidemiological Approach to Explore Transmission of Mycobacterium ulcerans

PLoS neglected tropical diseases · 2016 · 17 citations

Antimycobacterial ingredients from plants used in traditional medicine to treat Buruli ulcer

International Journal of Mycobacteriology · 2016 · 3 citations

Antimycobacterial potency and cytotoxicity study of three medicinal plants

International Journal of Mycobacteriology · 2016 · 2 citations

Challenging dogma and stagnation in TB research

International Journal of Mycobacteriology · 2016 · 1 citations

Towards host-directed therapies for tuberculosis

Nature Reviews Drug Discovery · 2015 · 129 citations

Current perspectives in drug discovery against tuberculosis from natural products

International Journal of Mycobacteriology · 2015 · 102 citations

Medicinal plants used to treat TB in Ghana

International Journal of Mycobacteriology · 2015 · 95 citations

Mycobacterium africanum Is Associated with Patient Ethnicity in Ghana

PLoS neglected tropical diseases · 2015 · 81 citations

Methods used in preclinical assessment of anti-Buruli ulcer agents: A global perspective

Journal of Pharmacological and Toxicological Methods · 2015 · 5 citations

Prevalence of bovine tuberculosis in a dairy cattle farm and a research farm in Ghana

Onderstepoort Journal of Veterinary Research · 2014 · 19 citations

Secondary Bacterial Infections of Buruli Ulcer Lesions Before and After Chemotherapy with Streptomycin and Rifampicin

PLoS neglected tropical diseases · 2013 · corresponding author · 75 citations