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Stephaney Gyaase

University Medical Center Utrecht

65 publications · 1,354 citations · ORCID 0000-0003-2389-2307

Malaria Research and ControlGlobal Maternal and Child HealthEnergy and Environment ImpactsAir Quality and Health ImpactsMosquito-borne diseases and control

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Stephaney Gyaase is a public health researcher specializing in epidemiology and disease control in Ghana, with a strong focus on malaria, household air pollution, and maternal and child health. Gyaase utilizes longitudinal cohort studies, randomized controlled trials, and demographic surveillance systems to investigate disease patterns, vaccine efficacy, and the impacts of environmental interventions. Recent work has expanded into digital health, applying machine learning to predict vaccination defaulters and analyzing health information systems.

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What is the comparative efficacy of household water treatment interventions versus improved water source infrastructure in reducing stunting among children under five in low- and middle-income countries?

Why this gap exists: While the retrieved literature confirms associations between water quality and child growth (e.g., Abstracts 2, 5, 8), no study directly compares the efficacy of household water treatment interventions against improved water source infrastructure for reducing stunting, leaving the specific comparative question unresolved.

Sources

  1. Determinants of stunting in Indonesian children: evidence from a cross-sectional survey indicate a prominent role for the water, sanitation and hygiene sector in stunting reduction — BMC Public Health, 2016
  2. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  3. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trial — The Lancet Global Health, 2018
  4. Effects of Water Pollution on Human Health and Disease Heterogeneity: A Review — Frontiers in Environmental Science, 2022
  5. Associated factors with malnutrition among children under-5 years old in Somaliland: evidence from Somaliland health and demographic survey of 2020. — BMC public health, 2026
  6. Safe Drinking Water and Its Impact on Children's Growth and Development: A Systematic Review. — International journal of environmental research and public health, 2026
  7. Modelling the impact of dietary diversity on child nutrition in Pakistan: a machine learning analysis with Shapley Additive exPlanations and Boruta interpretability. — Journal of global health, 2026
  8. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis — The Lancet, 2022
  9. Effect of Household Source of Drinking Water on Malnutrition among under Five Children in Ethiopia: Systematic Review and Meta-Analysis — 2026
  10. Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields — Water 2017, 9, 339, 2018

What is the comparative efficacy and cost-effectiveness of the one-step 75g OGTT versus the two-step (50g GCT followed by 100g OGTT) diagnostic approach in preventing adverse maternal and neonatal outcomes?

Why this gap exists: While Abstract [7] compares diagnostic criteria and Abstract [4] compares 75g and 100g OGTTs, the retrieved evidence lacks direct, comparative studies on the cost-effectiveness and relative efficacy of the one-step versus two-step *approaches* in preventing adverse outcomes, leaving the specific question unresolved.

Sources

  1. Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO Criteria — PLoS ONE, 2016
  2. A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes — New England Journal of Medicine, 2009
  3. Standards of Medical Care in Diabetes—2013 — Diabetes Care, 2012
  4. An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative Review — Diabetes Metabolic Syndrome and Obesity, 2021
  5. Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to detect gestational diabetes mellitus — Frontiers in Endocrinology, 2025
  6. Large language models for generating longitudinal synthetic data in low-risk pregnancy care. — Data in brief, 2026
  7. Effects of physical activity and diet in pregnancy to prevent gestational diabetes: an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation. — Health technology assessment (Winchester, England), 2026
  8. 187-OR: Randomized Clinical Trial of the IADPSG vs. Carpenter Coustan Criteria for Diagnosis of Gestational Diabetes Mellitus — Diabetes, 2020
  9. Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A cross-sectional study. — Diabetes & metabolic syndrome, 2019
  10. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026

What are the specific long-term treatment strategies required to mitigate the risk of developing chronic non-communicable diseases in children born to mothers with gestational diabetes mellitus?

Why this gap exists: While the retrieved literature consistently establishes that maternal gestational diabetes mellitus (GDM) increases the long-term risk of cardiometabolic diseases in offspring [1][2][3], it focuses primarily on pathogenesis and risk association rather than defining specific, evidence-based long-term treatment strategies for the children to mitigate these risks.

Sources

  1. Diagnosis and Classification of Diabetes Mellitus — Diabetes Care, 2010
  2. A Clinical Update on Gestational Diabetes Mellitus — Endocrine Reviews, 2022
  3. Maternal Diabetes and Risk of Early-Onset Cardiovascular Diseases in Offspring. — JAMA cardiology, 2026
  4. Gestational diabetes as an inter-generational cardiometabolic risk factor: spotlight on emerging exerkines. — Cardiovascular diabetology, 2026
  5. Gestational diabetes: from pathogenesis to therapeutic intervention. — Diabetology & metabolic syndrome, 2026
  6. 2. Classification and Diagnosis of Diabetes:<i>Standards of Medical Care in Diabetes—2022</i> — Diabetes Care, 2021
  7. Maternal congenital heart disease and risk of child developmental vulnerability in early school age: A population-based cohort study. — PLoS medicine, 2026
  8. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026
  9. Gestational Diabetes and Obesity: Immediate and Late Sequelae for Offspring. — Children (Basel, Switzerland), 2025
  10. Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications — Diabetes & Metabolism Journal, 2022

How do specific policy frameworks regarding social protection and food systems in low-income countries moderate the projected increase in child wasting and maternal undernutrition caused by economic shocks like the COVID-19 pandemic?

Why this gap exists: While the retrieved literature confirms the projected increase in child wasting and maternal undernutrition due to COVID-19 disruptions [0] and explores general concepts of food system resilience [2] and social protection [3], no study directly quantifies how specific policy frameworks moderate these projected outcomes, leaving the core interaction unresolved.

Sources

  1. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  2. Biofortification as a sustainable strategy to address micronutrient malnutrition in South Asia. — Journal of health, population, and nutrition, 2025
  3. Resilience of local food systems and links to food security – A review of some important concepts in the context of COVID-19 and other shocks — Food Security, 2020
  4. Resilience and Recovery in the Informal Economy: Social Networks, Social Protection, and Adaptive Strategies Among Post-COVID Workers in Bangladesh. — Public health challenges, 2026
  5. Malnutrition at a Crossroads: The Impact of Pandemic, Climate Change, and War on Tigray’s Children Malnutrition — 2026
  6. Economic Shocks, Inequality and Poverty: The Need for Safety Nets — 1998
  7. Lessons from low-to middle-income countries on the development of child protection systems — The Development of Child Protection Systems and Practice in Low- to Middle-Income Countries, 2025
  8. Drivers of Stunting Reduction in Yogyakarta, Indonesia: A Case Study. — International journal of environmental research and public health, 2022
  9. Inequality, mobility and the financial accumulation process: A computational economic analysis — Journal of Economic Interaction and Coordination (2020), online, 2019
  10. The Role of Agriculture in Ensuring Food Security in Developing Countries: Considerations in the Context of the Problem of Sustainable Food Production — Sustainability, 2020

How do specific maternal microbiota profiles (gut, oral, or vaginal) during gestation correlate with the development of gestational diabetes mellitus (GDM) and subsequent long-term metabolic health in offspring?

Why this gap exists: While recent reviews [8] confirm GDM alters maternal gut microbiota and neonatal health, and older studies [0] note dysbiosis across maternal sites, the retrieved evidence lacks direct, longitudinal studies correlating specific gestational maternal microbiota profiles with the *long-term* metabolic health of offspring, leaving the core question unresolved.

Sources

  1. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus — Gut, 2018
  2. Dysbiosis of the gut microbiota in disease — Microbial Ecology in Health and Disease, 2015
  3. Temporal development of the gut microbiome in early childhood from the TEDDY study — Nature, 2018
  4. Microbiota in health and diseases — Signal Transduction and Targeted Therapy, 2022
  5. Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis — Hormone and Metabolic Research, 2024
  6. Perinatal phlorizin alleviates maternal high-fat diet-induced metabolic syndrome in female mouse offspring and is associated with modulation of the gut microbiota. — Frontiers in nutrition, 2026
  7. Offspring long-term infectious morbidity following pregnancies with cervical cerclage. — Archives of gynecology and obstetrics, 2026
  8. Interaction between microbiota and immunity in health and disease — Cell Research, 2020
  9. Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions. — Journal of translational medicine, 2026
  10. Microbes in the Moonlight: How the Gut Microbiota Influences Sleep — arXiv preprint, 2025

What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

  1. New developments in tuberculosis diagnosis and treatment — Breathe, 2022
  2. Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
  3. Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
  4. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
  5. Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
  6. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
  7. Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
  8. Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
  9. Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
  10. Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

Publications

The Malaria Vaccine Implementation Programme study area in Ghana: results of a household survey prior to the introduction of the RTS,S/AS01 vaccine

Figshare · 2026

Additional file 1 of The Malaria Vaccine Implementation Programme study area in Ghana: results of a household survey prior to the introduction of the RTS,S/AS01 vaccine

Open MIND · 2026

Additional file 1 of The Malaria Vaccine Implementation Programme study area in Ghana: results of a household survey prior to the introduction of the RTS,S/AS01 vaccine

Figshare · 2026

Mortality Trends in the Kintampo Health and Demographic Surveillance System, Ghana (2011—2024)

Research Connections · 2026

Prenatal and child malaria and child growth: evidence from a Ghanaian pregnancy cohort

BMJ Paediatrics Open · 2026

The Malaria Vaccine Implementation Programme study area in Ghana: results of a household survey prior to the introduction of the RTS,S/AS01 vaccine

Malaria Journal · 2026

The Malaria Vaccine Implementation Programme study area in Ghana: results of a household survey prior to the introduction of the RTS,S/AS01 vaccine

Figshare · 2026

Climate, Air Quality and Their Contribution to Cardiovascular Disease Morbidity and Mortality in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Global Heart · 2025 · 8 citations

Prevalence of Large‐for‐Gestational Age and Macrosomia Among Livebirths in 23 Low‐ and Middle‐Income Countries Between 2000 and 2021: An Individual Participant Data Analysis

BJOG An International Journal of Obstetrics & Gynaecology · 2025 · 2 citations

Advancing Knowledge on Machine Learning Algorithms for Predicting Childhood Vaccination Defaulters in Ghana: A Comparative Performance Analysis

Applied Sciences · 2025 · 1 citations

Feature representation in analysing childhood vaccination defaulter risk predictors: A scoping review of studies in low-resource settings

PLOS Digital Health · 2025 · corresponding author · 1 citations

Risk prediction models to determine maternal and newborn adverse pregnancy outcomes in low and middle-income countries: A scoping review protocol

PLoS ONE · 2025 · corresponding author

Adherence to the Test, Treat and Track malaria policy among selected health facilities in Ghana: The clients’ perspective

Research Square · 2025

Adherence to the test, treat and track malaria policy among selected health facilities in Ghana: the clients’ perspective

Malaria Journal · 2025

Prevalence and factors associated with malaria among children aged 6 months to 10 years in the Greater Accra Region of Ghana: a community-based cross-sectional survey

Malaria Journal · 2024 · 12 citations

Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low‐ and middle‐income countries, 2000–2017

BJOG An International Journal of Obstetrics & Gynaecology · 2024 · 11 citations

Neonatal mortality risk of vulnerable newborns: A descriptive analysis of subnational, population‐based birth cohorts for 238 203 live births in low‐ and middle‐income settings from 2000 to 2017

BJOG An International Journal of Obstetrics & Gynaecology · 2023 · 20 citations

Prevalence and determinants of caesarean section deliveries in the Kintampo Districts of Ghana

BMC Pregnancy and Childbirth · 2023 · 20 citations

Background malaria incidence and parasitemia during the three-dose RTS,S/AS01 vaccination series do not reduce magnitude of antibody response nor efficacy against the first case of malaria

BMC Infectious Diseases · 2023 · 8 citations

Association between malaria and household air pollution interventions in a predominantly rural area of Ghana

Malaria Journal · 2023 · 2 citations

Malaria Transmission Intensity and Parasitemia during the Three-Dose RTS,S/AS01 Vaccination Series do not Reduce Magnitude of Antibody Response nor Efficacy Against the First Case of Malaria

Research Square · 2023 · 2 citations

Did COVID-19 Change the Availability and Use of Clean Energy for Cooking? Evidence From Ghana

Environmental Health Insights · 2023

“I don’t want to have anything to do with someone suspected of COVID-19”: a genuine infection avoidance interests or inappropriate concerns related to stigma?

Journal of Public Health in Africa · 2023 · corresponding author

Malaria Transmission Intensity Likely Modifies RTS, S/AS01 Efficacy Due to a Rebound Effect in Ghana, Malawi, and Gabon

The Journal of Infectious Diseases · 2022 · 14 citations

Head Injury Prevalence in a Population of Injured Patients Seeking Care in Ghana, West Africa

Frontiers in Neurology · 2022 · 12 citations

The Association between Household Air Pollution and Blood Pressure in Obuasi Municipality, Ghana

Atmosphere · 2022 · 4 citations

Risk factors for COVID-19 virus infection among health workers: A case-control study in the Bono East Region of Ghana

American Journal of Infection Control · 2022 · 4 citations

Particulate Matter (Pm2.5) concentration among hypertensives primary cooks in Obuasi Municipality, Ghana

ISEE Conference Abstracts · 2022

Determinants of clean cooking fuels utilization in three peri-urban communities in Ghana: key lessons to inform national policy

ISEE Conference Abstracts · 2022

A cluster randomised trial of cookstove interventions to improve infant health in Ghana

BMJ Global Health · 2021 · 63 citations

Prenatal and Postnatal Household Air Pollution Exposure and Infant Growth Trajectories: Evidence from a Rural Ghanaian Pregnancy Cohort

Environmental Health Perspectives · 2021 · 58 citations

Prenatal household air pollutant exposure is associated with reduced size and gestational age at birth among a cohort of Ghanaian infants

Environment International · 2021 · 42 citations

Prenatal and Postnatal Household Air Pollution Exposures and Pneumonia Risk

CHEST Journal · 2021 · 38 citations

Potential effect modification of RTS,S/AS01 malaria vaccine efficacy by household socio-economic status

BMC Public Health · 2021 · 10 citations

Correction: Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana

PLoS ONE · 2021 · 2 citations

Corrigendum to “Prenatal household air pollutant exposure is associated with reduced size and gestational age at birth among a cohort of Ghanaian infants” [Environ. Int. 155 (2021) 106659]

Environment International · 2021 · 2 citations

Determinants of the varied profiles of Plasmodium falciparum infections among infants living in Kintampo, Ghana

Malaria Journal · 2021 · 2 citations

Impact of COVID-19 on household energy use in Ghana

ISEE Conference Abstracts · 2021

Constructing clean cookstove stack in Ghana

ISEE Conference Abstracts · 2021

Determinants of Inappropriate Antibiotics Use in Rural Central Ghana Using a Mixed Methods Approach

Frontiers in Public Health · 2020 · 77 citations

Utilization of the national cluster of district health information system for health service decision-making at the district, sub-district and community levels in selected districts of the Brong Ahafo region in Ghana

BMC Health Services Research · 2020 · 57 citations

Profiles of Plasmodium falciparum infections detected by microscopy through the first year of life in Kintampo a high transmission area of Ghana

PLoS ONE · 2020 · 12 citations

Time Use Implication of Clean Cookstoves in Rural Settings in Ghana: A Time Use Study

International Journal of Environmental Research and Public Health · 2020 · 9 citations

Geospatial analysis of malaria mortality in the kintampo health and demographic surveillance area of central Ghana

Annals of GIS · 2020 · 8 citations

Prevalence of Hypertension in the Middle Belt of Ghana: A Community‐Based Screening Study

International Journal of Hypertension · 2019 · 54 citations

Intermittent preventive treatment of pregnant women in Kintampo area of Ghana with sulphadoxine-pyrimethamine (SP): trends spanning 2011 and 2015

BMJ Open · 2019 · 44 citations

Prenatal maternal stress and birth outcomes in rural Ghana: sex-specific associations

BMC Pregnancy and Childbirth · 2019 · 37 citations

284: Prenatal household air pollution exposure associated with lower birth weight and length in rural Ghana

American Journal of Obstetrics and Gynecology · 2019 · 1 citations

Dynamics of asymptomatic infections and symptomatic malaria show different temporal profiles among infants living in a high transmission area of Ghana

Research Square (Research Square) · 2019

Epidemiology of soil transmitted Helminth infections in the middle-belt of Ghana, Africa

Parasite Epidemiology and Control · 2018 · 65 citations

Experiences with the Mass Distribution of LPG Stoves in Rural Communities of Ghana

EcoHealth · 2018 · 40 citations

Opinions of Health Professionals on Tailoring Reproductive Health Services to the Needs of Adolescents

International Journal of Reproductive Medicine · 2018 · 10 citations

Quality of Artemisinin-based Combination Therapy for malaria found in Ghanaian markets and public health implications of their use

BMC Pharmacology and Toxicology · 2016 · 34 citations

Economic costs of fever to households in the middle belt of Ghana

Malaria Journal · 2016 · 29 citations

The application of a biometric identification technique for linking community and hospital data in rural Ghana

Global Health Action · 2016 · 27 citations

Use of antimalarials among participants who sought treatment for fever.

Figshare · 2016

Univariate and multivariate logistic logistic regression for predictors of fever among 341 residents of the Kintampo North Municipality and Kintampo South District.

Figshare · 2016

Univariate and multivariate logistic logistic regression for predictors of malaria infection among residents of the Kintampo North Municipality and Kintampo South District.

Figshare · 2016

Demographic characteristics of 1436 participants, reported fever and parasitaemia infection at household and individual levels.

Figshare · 2016

Predictors of abortions in Rural Ghana: a cross-sectional study

BMC Public Health · 2015 · 65 citations

Provider compliance to artemisinin-based combination therapy at primary health care facilities in the middle belt of Ghana

Malaria Journal · 2015 · 17 citations

Family Planning Awareness, Perceptions and Practice among Community Members in the Kintampo Districts of Ghana

Advances in Reproductive Sciences · 2015 · 15 citations

Use of Antimalarial in the Management of Fever during a Community Survey in the Kintampo Districts of Ghana

PLoS ONE · 2015 · 9 citations

An Evaluation of the Clinical Assessments of Under-Five Febrile Children Presenting to Primary Health Facilities in Rural Ghana

PLoS ONE · 2011 · 54 citations