Simon K. Attah

University of Ghana

67 publications · 2,571 citations

Parasitic Diseases Research and TreatmentParasites and Host InteractionsMalaria Research and ControlMosquito-borne diseases and controlInsects and Parasite Interactions

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Simon K. Attah is a public health researcher specializing in parasitology, entomology, and infectious disease epidemiology, with a primary focus on onchocerciasis and malaria vector control in Ghana. Attah's work spans clinical trials of macrofilaricidal drugs, investigations into insecticide resistance mechanisms, and studies on the ecology of malaria vectors. The research portfolio demonstrates a long-standing engagement with onchocerciasis treatment strategies and a more recent expansion into urban malaria transmission and arboviral vector surveillance.

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What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

New developments in tuberculosis diagnosis and treatment — Breathe, 2022
Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

How does the consumption of plant-based proteins, specifically those high in anti-nutritional factors like phytates and trypsin inhibitors, affect mineral bioavailability and growth outcomes in children relying on these proteins as primary staples?

Why this gap exists: While the retrieved papers confirm that anti-nutritional factors like phytates and trypsin inhibitors reduce mineral bioavailability [0, 2], they focus on general adult health or crop improvement [1, 6] and do not provide direct evidence on the specific growth outcomes in children relying on these proteins as primary staples.

Sources

Plant food anti-nutritional factors and their reduction strategies: an overview — Food Production Processing and Nutrition, 2020
Sustaining Protein Nutrition Through Plant-Based Foods — Frontiers in Nutrition, 2022
Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds — Nutrients, 2020
Faba Bean: An Untapped Source of Quality Plant Proteins and Bioactives — Nutrients, 2022
Nutritional properties and health aspects of pulses and their use in plant‐based yogurt alternatives — Comprehensive Reviews in Food Science and Food Safety, 2021
Grains – a major source of sustainable protein for health — Nutrition Reviews, 2021
Healthy and Resilient Cereals and Pseudo-Cereals for Marginal Agriculture: Molecular Advances for Improving Nutrient Bioavailability — Frontiers in Genetics, 2020
Protein Quality in Perspective: A Review of Protein Quality Metrics and Their Applications — Nutrients, 2022
Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases — Nutrients, 2021
Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits — Frontiers in Nutrition, 2020

What is the comparative effectiveness of telemedicine versus traditional in-person care in maintaining essential antenatal coverage and reducing maternal mortality in low-income and middle-income countries during future health system shocks?

Why this gap exists: While abstracts [4], [7], [8], and [9] discuss digital tools and maternity care in low- and middle-income countries, none provide a direct comparative effectiveness analysis of telemedicine versus in-person care regarding maternal mortality during health system shocks, leaving the specific question unresolved.

Sources

COVID-19 and resilience of healthcare systems in ten countries — Nature Medicine, 2022
Community Health Workers Can Provide Psychosocial Support to the People During COVID-19 and Beyond in Low- and Middle- Income Countries — Frontiers in Public Health, 2021
Social Impacts and Responses Related to COVID-19 in Low- and Middle-income Countries — OpenDocs (Institute of Development Studies), 2020
Seizing the moment to rethink health systems — The Lancet Global Health, 2021
Use of mHealth in promoting maternal and child health in “BIMARU” states of India “A health system strengthening strategy”: Systematic literature review — PLOS Digital Health, 2024
Investments for effective functionality of health systems towards Universal Health Coverage in Africa: A scoping review — PLOS Global Public Health, 2022
Infant and young child feeding — OECD eBooks, 2023
Facilitators and barriers to the implementation of a Mobile Health Wallet for pregnancy-related health care: A qualitative study of stakeholders’ perceptions in Madagascar — PLoS ONE, 2020
The impact of digital interventions on health insurance coverage for reproductive, maternal, newborn and child health services utilization in Kakamega, Kenya: a cluster randomized controlled trial — Health Policy and Planning, 2024
Seeking digital maternity healthcare during the pandemic health system shock: a systematic review of women's experiences in low- and middle-income countries — Frontiers in Reproductive Health, 2026

How do specific policy interventions aimed at improving female education and labor force participation accelerate the 'maternal mortality transition' in regions currently experiencing high maternal mortality?

Why this gap exists: While the retrieved literature establishes links between female education, political power, and health outcomes (e.g., [3], [6], [9]), no study directly addresses how specific labor or education policy interventions accelerate the 'maternal mortality transition' in high-mortality regions, leaving the mechanism and impact of such specific policies unresolved.

Sources

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 — The Lancet, 2024
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 — The Lancet, 2024
Determinants of female labor force participation: implications for policy in Qatar — Cogent Social Sciences, 2022
Maternal Mortality and Women’s Political Power — Journal of the European Economic Association, 2023
The labor force participation of Indian women before and after widowhood — Demographic Research, 2020
The public health effects of interventions similar to basic income: a scoping review — The Lancet Public Health, 2020
Differential impact of maternal education on under-five mortality in rural and urban India — Health & Place, 2023
Public Health Expenditure and Under-five Mortality in Nigeria: An Overview for Policy Intervention — Open Access Macedonian Journal of Medical Sciences, 2020
Efficacy of companion-integrated childbirth preparation for childbirth fear, self-efficacy, and maternal support in primigravid women in Malawi — BMC Pregnancy and Childbirth, 2020
The contribution of female health to economic development — The Economic Journal, 2020

How does the longitudinal trajectory of maternal stress and resilience during pregnancy specifically mediate the association between social determinants of health (e.g., socioeconomic status, structural inequality) and infant cognitive or emotional development outcomes?

Why this gap exists: While the retrieved literature confirms associations between socioeconomic disadvantage, maternal stress, and infant neurodevelopment, it does not resolve the specific question of how longitudinal trajectories of maternal stress and resilience mediate these associations, as the studies focus on broad correlations or static measures rather than dynamic mediation pathways.

Sources

Maternal Depression During Pregnancy and the Postnatal Period — JAMA Psychiatry, 2013
Socioeconomic disadvantage, gestational immune activity, and neurodevelopment in early childhood — Proceedings of the National Academy of Sciences, 2017
Disrupted beginnings: Neurodevelopmental outcomes of COVID-19 lockdowns in early childhood (Review). — Experimental and therapeutic medicine, 2026
Pregnancy as a period of risk, adaptation, and resilience for mothers and infants — Development and Psychopathology, 2020
The influence of attachment and relational quality on developmental outcomes across the lifespan: a systematic review and meta-analytic insights (2014-2024). — Frontiers in psychology, 2026
Nutrition as the Foundation of Human Capital: Pathways to Holistic Development. — Maternal & child nutrition, 2026
Chronic stress may disrupt covariant fluctuations of vitamin D and cortisol plasma levels in pregnant sheep during the last trimester: a preliminary report — arXiv preprint, 2019
Resilience and Stress during Pregnancy: A Comprehensive Multidimensional Approach in Maternal and Perinatal Health — The Scientific World JOURNAL, 2021
Maternal Stress During Pregnancy and Infant and Child Outcome — Oxford Handbooks Online, 2014
Maternal Docosahexaenoic Acid Status During Pregnancy and Its Impact on Infant Neurodevelopment — 2020

Publications

Comparative analysis reveals concentration-dependent and site-specific detoxification gene expression patterns in pyrethroid-resistant Anopheles gambiae s.l. from Accra, Ghana

Scientific Reports · 2026 · 1 citations

High resistance of Anopheles gambiae s.L. populations to public health insecticides in Ghana: contribution of domestic and agricultural pesticide use

BMC Infectious Diseases · 2026

Prevalence and Awareness of HIV and Hepatitis B Infections among Blood Donors at the Greater Accra Regional Hospital-Ridge

Open MIND · 2026

Prevalence and Awareness of HIV and Hepatitis B Infections among Blood Donors at the Greater Accra Regional Hospital-Ridge

Zenodo (CERN European Organization for Nuclear Research) · 2026

Insecticide resistance dynamics in Anopheles gambiae s.l. in Ghana

Gigabyte · 2026

Environmental contaminants drive insecticide resistance in Anopheles mosquitoes in Ghana

Scientific Reports · 2025 · 6 citations

Urban malaria in Accra, Ghana: transmission risk and influence of irrigated vegetable farms

BMC Infectious Diseases · 2025 · 4 citations

Malaria transmission risk in the city of Accra, Ghana: vector behavior and distribution

Research Square · 2025 · 3 citations

Insecticide resistance dynamics in Aedes mosquitoes in Ghana

Gigabyte · 2025 · 2 citations

Are Environmental volatiles contributing to Insecticide resistance in Anopheles Mosquitoes in Ghana?

Research Square · 2025 · 1 citations

Larval habitat diversity, physicochemical characteristics and their effect on the larval density of malaria vectors in the city of Accra, Ghana

Malaria Journal · 2025 · 1 citations

Larval habitat diversity, physicochemical characteristics and their effect on the larval density of malaria vectors in the city of Accra, Ghana

Research Square · 2025

Baseline susceptibility of Anopheles gambiae to clothianidin in northern Ghana

Malaria Journal · 2024 · 8 citations

Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia

Parasites & Vectors · 2024 · 5 citations

Risk of arboviral transmission and insecticide resistance status of Aedes mosquitoes during a yellow fever outbreak in Ghana

BMC Infectious Diseases · 2024 · 5 citations

Risk of Arboviral Transmission and Insecticide Resistance Status of Aedes Mosquitoes during a Yellow Fever Outbreak in Ghana

Research Square · 2024

Larval habitat diversity, physicochemical characterization and their effect on the density of larval malaria vectors in the city of Accra, Ghana

Research Square · 2024

Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?

Philosophical Transactions of the Royal Society B Biological Sciences · 2023 · 33 citations

Insecticide resistance status of Aedes aegypti in southern and northern Ghana

Parasites & Vectors · 2023 · 25 citations

In vitro antimicrobial activity of crude propolis extracts and fractions

FEMS Microbes · 2023 · 17 citations

Perceptions of the roles, impact, challenges and needs of community drug distributors in the control and elimination of neglected tropical diseases in difficult-to-access communities in Ghana

BMC Infectious Diseases · 2023 · 8 citations

Coverage of preventive measures and surveillance for neglected tropical diseases in hard-to-reach communities in Ghana

BMC Public Health · 2023 · 5 citations

O. volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: Results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia

Research Square · 2023 · 1 citations

Perceptions of the roles, impact, challenges and needs of community drug distributors in the control and elimination of neglected tropical diseases in difficult-to-access communities in Ghana

Research Square · 2023

Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection

PLoS neglected tropical diseases · 2022 · 155 citations

Effect of a single dose of 8 mg moxidectin or 150 μg/kg ivermectin on O. volvulus skin microfilariae in a randomized trial: Differences between areas in the Democratic Republic of the Congo, Liberia and Ghana and impact of intensity of infection

PLoS neglected tropical diseases · 2022 · corresponding author · 148 citations

The resting behavior of malaria vectors in different ecological zones of Ghana and its implications for vector control

Parasites & Vectors · 2022 · 35 citations

Preliminary Investigation into Plasmodium-like Piroplasms (Babesia/Theileria) among Cattle, Dogs and Humans in A Malaria-Endemic, Resource-Limited Sub-Saharan African City

Medical Sciences · 2022 · 8 citations

Effect of a single dose of 8 mg moxidectin or 150 µg/kg ivermectin on O. volvulus skin microfilariae in a randomized trial: Differences between areas in the Democratic Republic of the Congo, Liberia and Ghana and impact of intensity of infection

medRxiv · 2022 · 3 citations

Insecticide resistance status of Aedes aegypti in Southern and Northern Ghana

Research Square · 2022 · 1 citations

Resting Behavior of Malaria Vectors in Ghana and Its Implication on Vector Control.

Research Square · 2022

Baseline susceptibility of Anopheles gambiae to clothianidin in northern Ghana

Research Square · 2022

Non-invasive Thermal Imaging for Estimation of the Fecundity of Live Female Onchocerca Worms

Lecture notes in computer science · 2022

Larval habitat diversity and Anopheles mosquito species distribution in different ecological zones in Ghana

Parasites & Vectors · 2021 · 69 citations

Infection of Plasmodium falciparum and helminths among school children in communities in Southern and Northern Ghana

BMC Infectious Diseases · 2021 · 22 citations

Co-Infection of Plasmodium Falciparum and Helminths Among School Children in Communities in Southern and Northern Ghana

Research Square · 2021

Ecology of Anopheles Mosquito Larvae in Different Ecological Zones in Ghana

Research Square · 2021

Cytological and Wet Mount Microscopic Observations Made in Urine ofSchistosoma haematobium-Infected Children: Hint of the Implication in Bladder Cancer

Canadian Journal of Infectious Diseases and Medical Microbiology · 2019 · 11 citations

Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial

The Lancet · 2018 · 306 citations

Moving on from antibiotic foot baths for the control of digital dermatitis

Veterinary Record · 2017 · 4 citations

DETERMINING THE OPTIMAL DOSE OF MOXIDECTIN FOR ONCHOCERCIASIS VIA PHARMACOKINETIC-PHARMACODYNAMIC (PK-PD) MODELLING OF DATA FROM HEALTHY VOLUNTEERS AND PATIENTS WITH ONCHOCERCIASIS

American Journal of Tropical Medicine and Hygiene · 2017 · 3 citations

Response to the Letter to the Editor by Eberhard et al.

Parasites & Vectors · 2017 · 2 citations

Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings

Parasites & Vectors · 2016 · 37 citations

Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana

BMC Research Notes · 2016 · corresponding author · 37 citations

Microbial Content of “Bowl Water” Used for Communal Handwashing in Preschools within Accra Metropolis, Ghana

International Journal of Microbiology · 2016 · 15 citations

Additional file 1: of Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings

Figshare · 2016

MOESM1 of Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana

Figshare · 2016

MOESM1 of Malaria, helminths and malnutrition: a cross-sectional survey of school children in the South-Tongu district of Ghana

Figshare · 2016

Additional file 1: of Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings

Figshare · 2016

The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data

Parasites & Vectors · 2015 · 197 citations

Prevalence of intestinal parasites among patients of a Ghanaian psychiatry hospital

BMC Research Notes · 2015 · 23 citations

Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch

Parasites & Vectors · 2015 · 15 citations

A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection

PLoS neglected tropical diseases · 2014 · 239 citations

A comparative survey of the prevalence of human parasites found in fresh vegetables sold in supermarkets and open-aired markets in Accra, Ghana

BMC Research Notes · 2014 · 141 citations

Microbial Carriage of Cockroaches at a Tertiary Care Hospital in Ghana

Environmental Health Insights · 2013 · 44 citations

Extracts of Euphorbia hirta Linn. (Euphorbiaceae) and Rauvolfia vomitoria Afzel (Apocynaceae) demonstrate activities against Onchocerca volvulus Microfilariae in vitro

BMC Complementary and Alternative Medicine · 2013 · corresponding author · 25 citations

Urinary Schistosomiasis in Children—Still a Concern in Part of the Ghanaian Capital City

Open Journal of Medical Microbiology · 2013 · 17 citations

Efficacy of a single oral dose of 8 mg Moxidectin vs. 150 mu g/kg ivermectin in onchocerca volvulus infection: results of a randomized, double-blind single dose phase 3 study in areas without mass treatment with ivermectin in Liberia, Ghana and DRC

Tropical Medicine & International Health · 2013 · 3 citations

Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

PLoS neglected tropical diseases · 2011 · 315 citations

Onchocerca volvulus, Ivermectin, Anthelmintic resistance, Genetic changes Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

2011

An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana

Annals of Tropical Medicine and Parasitology · 2004 · 226 citations

Thirty-month follow-up of sub-optimal responders to multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana

Annals of Tropical Medicine and Parasitology · 2004 · 149 citations

The safety, tolerability and pharmacokinetics of levamisole alone, levamisole plus ivermectin, and levamisole plus albendazole, and their efficacy against Onchocerca volvulus

Annals of Tropical Medicine and Parasitology · 2004 · 43 citations

The co-administration of ivermectin and albendazole - safety, pharmacokinetics and efficacy against Onchocerca volvulus

Annals of Tropical Medicine and Parasitology · 2003 · 63 citations

The effects of high-dose ivermectin regimens on Onchocerca volvulus in onchocerciasis patients

Transactions of the Royal Society of Tropical Medicine and Hygiene · 1999 · 73 citations

The safety and efficacy of amocarzine in African onchocerciasis and the influence of ivermectin on the clinical and parasitological response to treatment

Annals of Tropical Medicine and Parasitology · 1997 · 17 citations

The anterior central nervous system of male Onchocerca volvulus (Nematoda: Filarioidea) as a target for chemotherapy: results of an electron microscopy study

Parasitology Research · 1997 · 1 citations