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Alex Osei‐Akoto

Komfo Anokye Teaching Hospital

53 publications · 1,397 citations · ORCID 0000-0002-6764-4383

Hemoglobinopathies and Related DisordersIron Metabolism and DisordersMalaria Research and ControlBlood groups and transfusionPrenatal Screening and Diagnostics

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Alex Osei‐Akoto is a clinical researcher focused on hematology and pediatric infectious diseases in Ghana, with a primary emphasis on Sickle Cell Disease (SCD) and malaria. Osei‐Akoto has contributed to establishing SCD patient registries, evaluating clinical management protocols, and investigating the epidemiology of malaria in children. The research spans from early work on malaria pathogenesis and treatment to recent efforts in building research capacity and standardizing SCD care across Africa.

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What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

  1. New developments in tuberculosis diagnosis and treatment — Breathe, 2022
  2. Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
  3. Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
  4. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
  5. Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
  6. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
  7. Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
  8. Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
  9. Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
  10. Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

What is the comparative efficacy and cost-effectiveness of the one-step 75g OGTT versus the two-step (50g GCT followed by 100g OGTT) diagnostic approach in preventing adverse maternal and neonatal outcomes?

Why this gap exists: While Abstract [7] compares diagnostic criteria and Abstract [4] compares 75g and 100g OGTTs, the retrieved evidence lacks direct, comparative studies on the cost-effectiveness and relative efficacy of the one-step versus two-step *approaches* in preventing adverse outcomes, leaving the specific question unresolved.

Sources

  1. Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO Criteria — PLoS ONE, 2016
  2. A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes — New England Journal of Medicine, 2009
  3. Standards of Medical Care in Diabetes—2013 — Diabetes Care, 2012
  4. An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative Review — Diabetes Metabolic Syndrome and Obesity, 2021
  5. Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to detect gestational diabetes mellitus — Frontiers in Endocrinology, 2025
  6. Large language models for generating longitudinal synthetic data in low-risk pregnancy care. — Data in brief, 2026
  7. Effects of physical activity and diet in pregnancy to prevent gestational diabetes: an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation. — Health technology assessment (Winchester, England), 2026
  8. 187-OR: Randomized Clinical Trial of the IADPSG vs. Carpenter Coustan Criteria for Diagnosis of Gestational Diabetes Mellitus — Diabetes, 2020
  9. Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A cross-sectional study. — Diabetes & metabolic syndrome, 2019
  10. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026

What is the comparative efficacy of household water treatment interventions versus improved water source infrastructure in reducing stunting among children under five in low- and middle-income countries?

Why this gap exists: While the retrieved literature confirms associations between water quality and child growth (e.g., Abstracts 2, 5, 8), no study directly compares the efficacy of household water treatment interventions against improved water source infrastructure for reducing stunting, leaving the specific comparative question unresolved.

Sources

  1. Determinants of stunting in Indonesian children: evidence from a cross-sectional survey indicate a prominent role for the water, sanitation and hygiene sector in stunting reduction — BMC Public Health, 2016
  2. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  3. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trial — The Lancet Global Health, 2018
  4. Effects of Water Pollution on Human Health and Disease Heterogeneity: A Review — Frontiers in Environmental Science, 2022
  5. Associated factors with malnutrition among children under-5 years old in Somaliland: evidence from Somaliland health and demographic survey of 2020. — BMC public health, 2026
  6. Safe Drinking Water and Its Impact on Children's Growth and Development: A Systematic Review. — International journal of environmental research and public health, 2026
  7. Modelling the impact of dietary diversity on child nutrition in Pakistan: a machine learning analysis with Shapley Additive exPlanations and Boruta interpretability. — Journal of global health, 2026
  8. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis — The Lancet, 2022
  9. Effect of Household Source of Drinking Water on Malnutrition among under Five Children in Ethiopia: Systematic Review and Meta-Analysis — 2026
  10. Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields — Water 2017, 9, 339, 2018

What are the specific long-term treatment strategies required to mitigate the risk of developing chronic non-communicable diseases in children born to mothers with gestational diabetes mellitus?

Why this gap exists: While the retrieved literature consistently establishes that maternal gestational diabetes mellitus (GDM) increases the long-term risk of cardiometabolic diseases in offspring [1][2][3], it focuses primarily on pathogenesis and risk association rather than defining specific, evidence-based long-term treatment strategies for the children to mitigate these risks.

Sources

  1. Diagnosis and Classification of Diabetes Mellitus — Diabetes Care, 2010
  2. A Clinical Update on Gestational Diabetes Mellitus — Endocrine Reviews, 2022
  3. Maternal Diabetes and Risk of Early-Onset Cardiovascular Diseases in Offspring. — JAMA cardiology, 2026
  4. Gestational diabetes as an inter-generational cardiometabolic risk factor: spotlight on emerging exerkines. — Cardiovascular diabetology, 2026
  5. Gestational diabetes: from pathogenesis to therapeutic intervention. — Diabetology & metabolic syndrome, 2026
  6. 2. Classification and Diagnosis of Diabetes:<i>Standards of Medical Care in Diabetes—2022</i> — Diabetes Care, 2021
  7. Maternal congenital heart disease and risk of child developmental vulnerability in early school age: A population-based cohort study. — PLoS medicine, 2026
  8. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026
  9. Gestational Diabetes and Obesity: Immediate and Late Sequelae for Offspring. — Children (Basel, Switzerland), 2025
  10. Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications — Diabetes & Metabolism Journal, 2022

How do specific policy frameworks regarding social protection and food systems in low-income countries moderate the projected increase in child wasting and maternal undernutrition caused by economic shocks like the COVID-19 pandemic?

Why this gap exists: While the retrieved literature confirms the projected increase in child wasting and maternal undernutrition due to COVID-19 disruptions [0] and explores general concepts of food system resilience [2] and social protection [3], no study directly quantifies how specific policy frameworks moderate these projected outcomes, leaving the core interaction unresolved.

Sources

  1. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
  2. Biofortification as a sustainable strategy to address micronutrient malnutrition in South Asia. — Journal of health, population, and nutrition, 2025
  3. Resilience of local food systems and links to food security – A review of some important concepts in the context of COVID-19 and other shocks — Food Security, 2020
  4. Resilience and Recovery in the Informal Economy: Social Networks, Social Protection, and Adaptive Strategies Among Post-COVID Workers in Bangladesh. — Public health challenges, 2026
  5. Malnutrition at a Crossroads: The Impact of Pandemic, Climate Change, and War on Tigray’s Children Malnutrition — 2026
  6. Economic Shocks, Inequality and Poverty: The Need for Safety Nets — 1998
  7. Lessons from low-to middle-income countries on the development of child protection systems — The Development of Child Protection Systems and Practice in Low- to Middle-Income Countries, 2025
  8. Drivers of Stunting Reduction in Yogyakarta, Indonesia: A Case Study. — International journal of environmental research and public health, 2022
  9. Inequality, mobility and the financial accumulation process: A computational economic analysis — Journal of Economic Interaction and Coordination (2020), online, 2019
  10. The Role of Agriculture in Ensuring Food Security in Developing Countries: Considerations in the Context of the Problem of Sustainable Food Production — Sustainability, 2020

What is the comparative effectiveness of telemedicine versus traditional in-person care in maintaining essential antenatal coverage and reducing maternal mortality in low-income and middle-income countries during future health system shocks?

Why this gap exists: While abstracts [4], [7], [8], and [9] discuss digital tools and maternity care in low- and middle-income countries, none provide a direct comparative effectiveness analysis of telemedicine versus in-person care regarding maternal mortality during health system shocks, leaving the specific question unresolved.

Sources

  1. COVID-19 and resilience of healthcare systems in ten countries — Nature Medicine, 2022
  2. Community Health Workers Can Provide Psychosocial Support to the People During COVID-19 and Beyond in Low- and Middle- Income Countries — Frontiers in Public Health, 2021
  3. Social Impacts and Responses Related to COVID-19 in Low- and Middle-income Countries — OpenDocs (Institute of Development Studies), 2020
  4. Seizing the moment to rethink health systems — The Lancet Global Health, 2021
  5. Use of mHealth in promoting maternal and child health in “BIMARU” states of India “A health system strengthening strategy”: Systematic literature review — PLOS Digital Health, 2024
  6. Investments for effective functionality of health systems towards Universal Health Coverage in Africa: A scoping review — PLOS Global Public Health, 2022
  7. Infant and young child feeding — OECD eBooks, 2023
  8. Facilitators and barriers to the implementation of a Mobile Health Wallet for pregnancy-related health care: A qualitative study of stakeholders’ perceptions in Madagascar — PLoS ONE, 2020
  9. The impact of digital interventions on health insurance coverage for reproductive, maternal, newborn and child health services utilization in Kakamega, Kenya: a cluster randomized controlled trial — Health Policy and Planning, 2024
  10. Seeking digital maternity healthcare during the pandemic health system shock: a systematic review of women's experiences in low- and middle-income countries — Frontiers in Reproductive Health, 2026

Publications

Sickle Cell Disease in Africa: SickleInAfrica Registry in Ghana, Nigeria and Tanzania

eJHaem · 2025 · 9 citations

Clinical manifestations of sickle cell disease in Africa and its association with foetal haemoglobin parameters

Communications Medicine · 2025 · 9 citations

Transition Readiness of Pediatric Sickle Cell Patients to Adult Clinic in a Teaching Hospital, Ghana

Advances in Hematology · 2025 · 1 citations

Morbidity, Mortality, and Management of Sickle Cell Disease in Africa Before and During the Covid-19 Pandemic: A Multinational Hospital-Based Retrospective Cohort Study

SSRN Electronic Journal · 2025

Healthcare providers’ knowledge on sickle cell disease and its management: A pre- and post-training test evaluation outcome

PLoS ONE · 2025 · corresponding author

A contemporary evaluation of the frequency &amp; factors associated with overt stroke across the lifespan: A Ghanaian sickle cell disease registry analysis

Journal of the Neurological Sciences · 2024 · 2 citations

Adherence to routinely prescribed medications among paediatric sickle cell disease patients in Kumasi, Ghana

Ghana Medical Journal · 2024

A cross-sectional study of the clinical manifestations of Sickles Cell Disease in Ghana, Nigeria and Tanzania and its association with foetal haemoglobin parameters

Research Square · 2024

Hospitalizations among children with sickle cell disease enrolled in the Kumasi Sickle Cell Pan African Consortium (SPARCo) database: A cross sectional study

Health Science Reports · 2023 · 8 citations

Hemolysis scavenger proteins and renal function marker in children with sickle cell disease at steady state: A cross‐sectional study

Health Science Reports · 2023 · 3 citations

Establishing a Sickle Cell Disease Registry in Africa: Experience From the Sickle Pan-African Research Consortium, Kumasi-Ghana

Frontiers in Genetics · 2022 · 33 citations

Iron stores in steady‐state sickle cell disease children accessing care at a sickle cell disease clinic in Kumasi, Ghana: A cross‐sectional study

Health Science Reports · 2022 · 13 citations

Skills Capacity Building For Health Care Services and Research Through the Sickle Pan African Research Consortium

Frontiers in Genetics · 2022 · 11 citations

Penicillin V prophylaxis uptake among children living with sickle cell disease in a specialist sickle cell clinic in Ghana: A cross‐sectional study

Health Science Reports · 2022 · 4 citations

Hospitalizations among children with Sickle Cell Disease enrolled into the Kumasi SPARCo database

African Journal of Current Medical Research · 2022 · 1 citations

One third of alloantibodies in patients with sickle cell disease transfused with African blood are missed by the standard red blood cell test panel

Haematologica · 2021 · 18 citations

Stigma Associated With Sickle Cell Disease in Kumasi, Ghana

Journal of Transcultural Nursing · 2021 · 14 citations

Utilization of Pneumococcal Vaccine and Penicillin Prophylaxis in Sickle Cell Disease in Three African Countries: Assessment among Healthcare Providers in SickleInAfrica

Hemoglobin · 2021 · 12 citations

SickleInAfrica

The Lancet Haematology · 2020 · 52 citations

Point prevalence of asymptomatic Plasmodium infection and the comparison of microscopy, rapid diagnostic test and nested PCR for the diagnosis of asymptomatic malaria among children under 5 years in Ghana

PLoS ONE · 2020 · 20 citations

Caregiver Perception of Sickle Cell Disease Stigma in Ghana: An Ecological Approach

Journal of Pediatric Health Care · 2020 · 16 citations

Educating caregivers to recognise the clinical signs of pneumonia in children younger than 6 months

South African Journal of Child Health · 2020 · 2 citations

Social constructs, late recognition and decision making for managing fast breathing in children

Children and Youth Services Review · 2020 · 1 citations

The Sickle Cell Disease Ontology: enabling universal sickle cell-based knowledge representation

Database · 2019 · 28 citations

Red blood cell alloimmunization and minor red blood cell antigen phenotypes in transfused Ghanaian patients with sickle cell disease

Transfusion · 2019 · 21 citations

Decreased Mortality After Establishing a Pediatric Emergency Unit at an Urban Referral Hospital in Ghana

Pediatric Emergency Care · 2019 · corresponding author · 9 citations

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

The Lancet Haematology · 2018 · 122 citations

Microchimerism in Ghanaian children recipients of whole blood transfusion for severe anaemia

Vox Sanguinis · 2018 · 5 citations

Nutritional Intervention in Children Undergoing Chemotherapy for Cancer

Journal of Cancer and Tumor International · 2018 · 1 citations

Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana

BMJ Open · 2017 · 8 citations

Effects of chemotherapy and disease burden on the nutritional status of patients undergoing treatment for burkitt’s lymphoma

Der pharmacia lettre · 2015 · 1 citations

Hodgkins lymphoma: Clinicopathologic features in paediatric patients presenting at the Komfo Anokye Teaching Hospital-Kumasi.

Journal of Clinical Oncology · 2015

Fourteen‐year experience of a tertiary hospital transfusion committee in <scp>W</scp>est <scp>A</scp>frica

Transfusion · 2014 · 10 citations

The Drug Regimen Prescribed for Sickle Cell Patients Attending a Clinic in Kumasi, Ghana, in a Period of One Year

Open Journal of Blood Diseases · 2014 · 1 citations

The Diagnostic Implications of Spot Urinalysis of Subjects from a Ghanaian Sickle Cell Clinic

Journal of internal medicine research · 2014

Sickle Cell Disease: Management options and challenges in developing countries

Mediterranean Journal of Hematology and Infectious Diseases · 2013 · 63 citations

Haematological indices, nutritional assessment and mortality outcome of children presenting with severe malaria to a tertiary hospital in Ghana

DergiPark (Istanbul University) · 2013

Genome-wide association study indicates two novel resistance loci for severe malaria

Nature · 2012 · 280 citations

Some conventional and non-conventional hematological and biochemical markers for characterizing some acute and chronic presentations of sickle cell patients.

Journal of Investigational Biochemistry · 2012 · 1 citations

T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children

PLoS ONE · 2011 · 66 citations

Prognostic significance of biochemical markers in African Burkitt’s lymphoma

Clinical & Translational Oncology · 2011 · 4 citations

Exploring the relationship between chronic undernutrition and asymptomatic malaria in Ghanaian children

Malaria Journal · 2010 · 69 citations

Clinical and epidemiological characterisation of Burkitt’s lymphoma: an eight-year case study at Komfo Anokye Teaching Hospital, Ghana

British Journal of Biomedical Science · 2010 · 10 citations

Clinical and epidemiological characterisation of Burkitt’s lymphoma: an eight-year case study at Komfo Anokye Teaching Hospital, Ghana

British Journal of Biomedical Science · 2010 · 3 citations

Correction: Randomized Controlled Trial of RTS,S/AS02<sub>D</sub>and RTS,S/AS01<sub>E</sub>Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children

PLoS ONE · 2010

Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children

PLoS ONE · 2009 · 88 citations

von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation

British Journal of Haematology · 2006 · 126 citations

Malaria and anaemia among children in two communities of Kumasi, Ghana: a cross-sectional survey

Malaria Journal · 2006 · 80 citations

Urban malaria and anaemia in children: a cross‐sectional survey in two cities of Ghana

Tropical Medicine & International Health · 2006 · 71 citations

Capillary refill time as an independent prognostic indicator in severe and complicated malaria

The Journal of Pediatrics · 2006 · 62 citations

Atovaquone-proguanil for treating uncomplicated malaria

Cochrane Database of Systematic Reviews · 2005 · 41 citations

Dehydration and metabolic disturbance in Ghanaianchildren with severe malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene · 2003

Atovaquone-proguanil for treating uncomplicated malaria

The Cochrane Database of Systematic Reviews · 2003