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James Abugri

Navrongo Health Research Centre

53 publications · 511 citations · ORCID 0000-0003-1871-8048

Malaria Research and ControlMosquito-borne diseases and controlComputational Drug Discovery MethodsParasites and Host InteractionsIron Metabolism and Disorders

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James Abugri is a researcher focused on infectious diseases, particularly malaria, and non-communicable diseases such as diabetes and cardiovascular health within the Ghanaian context. Abugri's work spans molecular studies of *Plasmodium falciparum* drug resistance and invasion mechanisms to clinical analyses of early-onset diabetes and gestational diabetes mellitus. Additionally, Abugri contributes to research on environmental health, phytochemistry, and the immunology of pregnancy-associated malaria.

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How do specific maternal microbiota profiles (gut, oral, or vaginal) during gestation correlate with the development of gestational diabetes mellitus (GDM) and subsequent long-term metabolic health in offspring?

Why this gap exists: While recent reviews [8] confirm GDM alters maternal gut microbiota and neonatal health, and older studies [0] note dysbiosis across maternal sites, the retrieved evidence lacks direct, longitudinal studies correlating specific gestational maternal microbiota profiles with the *long-term* metabolic health of offspring, leaving the core question unresolved.

What are the specific long-term treatment strategies required to mitigate the risk of developing chronic non-communicable diseases in children born to mothers with gestational diabetes mellitus?

Why this gap exists: While the retrieved literature consistently establishes that maternal gestational diabetes mellitus (GDM) increases the long-term risk of cardiometabolic diseases in offspring [1][2][3], it focuses primarily on pathogenesis and risk association rather than defining specific, evidence-based long-term treatment strategies for the children to mitigate these risks.

What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

To what extent do changes in the maternal microbiota (gut, oral, or vaginal) during pregnancy mediate the relationship between maternal perinatal anxiety/depression and the neurodevelopmental outcomes of the offspring?

Why this gap exists: While recent studies confirm associations between maternal mental health and microbiota composition (Abstract 5, 8) and suggest the microbiome-gut-brain axis influences neurodevelopment (Abstract 0, 2), the retrieved evidence does not contain studies that directly test the mediating role of maternal microbiota changes between perinatal anxiety/depression and offspring neurodevelopmental outcomes.

What is the comparative efficacy and cost-effectiveness of the one-step 75g OGTT versus the two-step (50g GCT followed by 100g OGTT) diagnostic approach in preventing adverse maternal and neonatal outcomes?

Why this gap exists: While Abstract [7] compares diagnostic criteria and Abstract [4] compares 75g and 100g OGTTs, the retrieved evidence lacks direct, comparative studies on the cost-effectiveness and relative efficacy of the one-step versus two-step *approaches* in preventing adverse outcomes, leaving the specific question unresolved.

Sources

  1. Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO CriteriaPLoS ONE, 2016
  2. A Multicenter, Randomized Trial of Treatment for Mild Gestational DiabetesNew England Journal of Medicine, 2009
  3. Standards of Medical Care in Diabetes—2013Diabetes Care, 2012
  4. An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative ReviewDiabetes Metabolic Syndrome and Obesity, 2021
  5. Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to detect gestational diabetes mellitusFrontiers in Endocrinology, 2025
  6. Large language models for generating longitudinal synthetic data in low-risk pregnancy care.Data in brief, 2026
  7. Effects of physical activity and diet in pregnancy to prevent gestational diabetes: an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation.Health technology assessment (Winchester, England), 2026
  8. 187-OR: Randomized Clinical Trial of the IADPSG vs. Carpenter Coustan Criteria for Diagnosis of Gestational Diabetes MellitusDiabetes, 2020
  9. Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A cross-sectional study.Diabetes & metabolic syndrome, 2019
  10. Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health.International journal of women's health, 2026

What is the comparative efficacy of digital versus in-person delivery of mental health interventions for mitigating the increased risk of perinatal depression and anxiety in low-income and middle-income countries during future pandemic-like disruptions?

Why this gap exists: While abstracts [6] and [8] compare digital and in-person delivery during the pandemic, they are set in high-income contexts (Spain, unspecified high-income), and abstract [7] focuses on LMICs but lacks a comparative digital vs. in-person design, leaving the specific question of comparative efficacy in LMICs unresolved.

Sources

  1. Mobile Health for Perinatal Depression and Anxiety: Scoping ReviewJournal of Medical Internet Research, 2020
  2. Effects of COVID-19 on College Students’ Mental Health in the United States: Interview Survey StudyJournal of Medical Internet Research, 2020
  3. A Preventive Social Media Intervention for Perinatal Depression and Anxiety in Regional, Rural, and Remote Communities: Participatory Co-Design Study.Journal of medical Internet research, 2026
  4. Risk-Stratified Screening for Perinatal Depression and Anxiety: Integrating Sexual Function, Self-Esteem, and Psychosocial Context.Diagnostics (Basel, Switzerland), 2026
  5. A Brief Intervention for the Treatment of Anxiety in Pregnancy: A Pilot Randomized Controlled Trial (The TAP Study).Psychotherapy and psychosomatics, 2026
  6. Barriers to and Facilitators of User Engagement With Digital Mental Health Interventions: Systematic ReviewJournal of Medical Internet Research, 2021
  7. Engagement, efficacy, and experiences of psychotherapy for perinatal populations with depression and anxiety during the COVID-19 pandemic.Frontiers in psychiatry, 2025
  8. Integration of stepped care for perinatal mood and anxiety disorders among women attending maternal and child health clinics in Kenya: Protocol for a cluster randomized controlled trial.PloS one, 2026
  9. Internet-based interdisciplinary therapeutic group (Grupo Interdisciplinar Online, GIO) for perinatal anxiety and depression-a randomized pilot study during COVID-19.Archives of women's mental health, 2024
  10. Detecting anxiety and depression in dialogues: a multi-label and explainable approachde Arriba-Pérez, F., García-Méndez, S. (2024). Detecting anxiety and depression in dialogues: a multi-label and explainable approach. In Proceedings of the 3rd AIxIA Workshop on Artificial Intelligence For Healthcare (pp. 257-271), 2024
  11. Community Interventions for Addressing Postpartum Depression Across the United States: A Narrative Review.Cureus, 2026
  12. Perspectives and support needs for a spouse-inclusive digital intervention for perinatal depression and anxiety: a qualitative study.Women's health nursing (Seoul, Korea), 2026
  13. How effective are cognitive behavior therapies for major depression and anxiety disorders? A meta‐analytic update of the evidenceWorld Psychiatry, 2016
  14. Association between maternal and neonatal outcomes and psychosocial risk levels in pregnant women: a convergent parallel mixed methods study protocol.Reproductive health, 2026
  15. Detecting anxiety and depression in dialogues: a multi-label and explainable approachde Arriba-Pérez, F., García-Méndez, S. (2024). Detecting anxiety and depression in dialogues: a multi-label and explainable approach. In Proceedings of the 3rd AIxIA Workshop on Artificial Intelligence For Healthcare (pp. 257-271), 2024
  16. Multitask learning for recognizing stress and depression in social mediaOnline Social Networks and Media (Volumes: 37-38, September 2023), 2023
  17. Digital Cognitive Behavioral Therapy for Insomnia Versus Sleep Hygiene Education for Prevention of Perinatal Depression: Protocol for a Randomized Clinical Trial.JMIR research protocols, 2026

Publications

Soil quality and heavy metal contamination in an open dumpsite in Navrongo, Ghana

Environmental Monitoring and Assessment · 2024 · 8 citations

Early-onset diabetes in Africa: A mini-review of the current genetic profile

European Journal of Medical Genetics · 2023 · 3 citations

Recapitulating potential environmental and industrial applications of biomass wastes

Journal of Material Cycles and Waste Management · 2022 · 24 citations

Microbiota in a long survival discourse with the human host

Archives of Microbiology · 2022 · corresponding author · 11 citations

Microbiota in a Long Survival Discourse with the Human Host

Preprints.org · 2022 · corresponding author · 2 citations

Prevention and Treatment of Methotrexate-Induced Hepato toxicity: Potential of Natural Phytobioactive Compounds

HAL (Le Centre pour la Communication Scientifique Directe) · 2022 · 1 citations

Impact of default rate of antiretroviral use on viral load among HIV/AIDS patients in Tamale and Sunyani

Journal of Applied Biotechnology & Bioengineering · 2021 · corresponding author · 3 citations

Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites

bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations