Benjamin Amoani

University of Cape Coast

65 publications · 431 citations · ORCID 0000-0002-4086-3033

Iron Metabolism and DisordersMalaria Research and ControlParasites and Host InteractionsHemoglobinopathies and Related DisordersParasite Biology and Host Interactions

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Benjamin Amoani is a biomedical researcher specializing in immunology, infectious diseases, and molecular pathology within the Ghanaian context. Amoani's work focuses on the immunological interactions between co-infections such as malaria and hookworm, the identification of biomarkers for cancers and inflammatory disorders, and the evaluation of therapeutic interventions including micronutrient fortification and plant extracts.

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How does the consumption of plant-based proteins, specifically those high in anti-nutritional factors like phytates and trypsin inhibitors, affect mineral bioavailability and growth outcomes in children relying on these proteins as primary staples?

Why this gap exists: While the retrieved papers confirm that anti-nutritional factors like phytates and trypsin inhibitors reduce mineral bioavailability [0, 2], they focus on general adult health or crop improvement [1, 6] and do not provide direct evidence on the specific growth outcomes in children relying on these proteins as primary staples.

Sources

Plant food anti-nutritional factors and their reduction strategies: an overview — Food Production Processing and Nutrition, 2020
Sustaining Protein Nutrition Through Plant-Based Foods — Frontiers in Nutrition, 2022
Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds — Nutrients, 2020
Faba Bean: An Untapped Source of Quality Plant Proteins and Bioactives — Nutrients, 2022
Nutritional properties and health aspects of pulses and their use in plant‐based yogurt alternatives — Comprehensive Reviews in Food Science and Food Safety, 2021
Grains – a major source of sustainable protein for health — Nutrition Reviews, 2021
Healthy and Resilient Cereals and Pseudo-Cereals for Marginal Agriculture: Molecular Advances for Improving Nutrient Bioavailability — Frontiers in Genetics, 2020
Protein Quality in Perspective: A Review of Protein Quality Metrics and Their Applications — Nutrients, 2022
Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases — Nutrients, 2021
Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits — Frontiers in Nutrition, 2020

How do specific cultural beliefs regarding 'insufficient milk' in rural South African communities mediate the relationship between maternal dietary diversity and the introduction of prelacteal feeds?

Why this gap exists: While the retrieved papers discuss general breastfeeding barriers in South Africa [8] and cultural influences in other regions like Ethiopia [6] and Malaysia [9], none specifically address the mediation of 'insufficient milk' beliefs on the relationship between maternal dietary diversity and prelacteal feeds in rural South African communities.

Sources

African Political Systems. — American Sociological Review, 1940
Maternal nutrition counselling is associated with reduced stunting prevalence and improved feeding practices in early childhood: a post-program comparison study — Nutrition Journal, 2019
Trends and determinants of early initiation of breastfeeding and exclusive breastfeeding in Ethiopia from 2000 to 2016 — International Breastfeeding Journal, 2019
Marketing of commercial milk formula: a system to capture parents, communities, science, and policy — The Lancet, 2023
Facilitators, barriers, and factors determining the willingness to donate human milk among postpartum mothers in a tertiary women's hospital in Nepal: a cross-sectional study. — International breastfeeding journal, 2026
Assessment of Infant and Young Child Feeding Practices among Mothers Attending Maternal and Child Health Clinic at a Tertiary Hospital, North Karnataka, India - A Cross-sectional Study. — Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine, 2025
Sociocultural and structural influences on infant and young child feeding in pastoralist communities of Afar, Ethiopia: a qualitative phenomenological study. — BMJ open, 2026
Knowledge, attitude, and practice of exclusive breastfeeding among mothers in East Africa: a systematic review — International Breastfeeding Journal, 2020
Facilitators and barriers associated with breastfeeding among mothers attending primary healthcare facilities in Mpumalanga, South Africa. — Frontiers in nutrition, 2023
Assessing the Influence of Cultural Beliefs and Practices on Early Breastfeeding Initiation Rates in Rural Sarawak Communities, Malaysia — Scientific Journal of Pediatrics, 2023

What are the comparative efficacy and adherence rates of new short-course latent tuberculosis infection (LTBI) regimens versus traditional long-course therapies in high-burden, low-resource settings?

Why this gap exists: While a 2023 network meta-analysis [6] synthesizes general efficacy and adherence data for LTBI regimens, the retrieved evidence lacks direct comparative studies specifically focused on high-burden, low-resource settings, leaving the specific constraints of these environments unresolved.

Sources

New developments in tuberculosis diagnosis and treatment — Breathe, 2022
Latent Tuberculosis and HIV Infection — Current Infectious Disease Reports, 2020
Epidemic and pandemic viral infections: impact on tuberculosis and the lung — European Respiratory Journal, 2020
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems — Nature Reviews Drug Discovery, 2023
Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management — Frontiers in Cellular and Infection Microbiology, 2022
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline — American Journal of Respiratory and Critical Care Medicine, 2024
Efficacy and safety of different regimens in the treatment of patients with latent tuberculosis infection: a systematic review and network meta-analysis of randomized controlled trials — Archives of Public Health, 2023
Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model — Tuberculosis & respiratory diseases, 2023
Mind the gap – Managing tuberculosis across the disease spectrum — EBioMedicine, 2022
Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review — Drugs, 2024

To what extent do changes in the maternal microbiota (gut, oral, or vaginal) during pregnancy mediate the relationship between maternal perinatal anxiety/depression and the neurodevelopmental outcomes of the offspring?

Why this gap exists: While recent studies confirm associations between maternal mental health and microbiota composition (Abstract 5, 8) and suggest the microbiome-gut-brain axis influences neurodevelopment (Abstract 0, 2), the retrieved evidence does not contain studies that directly test the mediating role of maternal microbiota changes between perinatal anxiety/depression and offspring neurodevelopmental outcomes.

Sources

Parental microbiome programming of early-life neurodevelopment: multi-niche contributions through the microbiome-gut-brain axis. — Gut microbes, 2026
Dysbiosis of the gut microbiota in disease — Microbial Ecology in Health and Disease, 2015
Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner — Scientific Reports, 2017
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication — Frontiers in Endocrinology, 2020
Ultra-processed food consumption across early life: implications for pediatric health and disease risk. — Frontiers in nutrition, 2026
Mental health in early pregnancy: Interplay of objectively measured lifestyles, gut microbiota, and metabolomics. — iScience, 2026
The impact of maternal high-fat diet on offspring neurodevelopment — Frontiers in Neuroscience, 2022
Maternal education and offspring birthweight for gestational age: the mediating effect of smoking during pregnancy — arXiv preprint, 2020
Is Gut Microbiota Altered in Depression and Anxiety? — 2025
Vaginal Microbiota: A Critical Component of Reproductive Health and Pregnancy Outcomes — Vaginal Microbiota: A Critical Component of Reproductive Health and Pregnancy Outcomes, 2025

What is the comparative efficacy and cost-effectiveness of the one-step 75g OGTT versus the two-step (50g GCT followed by 100g OGTT) diagnostic approach in preventing adverse maternal and neonatal outcomes?

Why this gap exists: While Abstract [7] compares diagnostic criteria and Abstract [4] compares 75g and 100g OGTTs, the retrieved evidence lacks direct, comparative studies on the cost-effectiveness and relative efficacy of the one-step versus two-step *approaches* in preventing adverse outcomes, leaving the specific question unresolved.

Sources

Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO Criteria — PLoS ONE, 2016
A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes — New England Journal of Medicine, 2009
Standards of Medical Care in Diabetes—2013 — Diabetes Care, 2012
An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative Review — Diabetes Metabolic Syndrome and Obesity, 2021
Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to detect gestational diabetes mellitus — Frontiers in Endocrinology, 2025
Large language models for generating longitudinal synthetic data in low-risk pregnancy care. — Data in brief, 2026
Effects of physical activity and diet in pregnancy to prevent gestational diabetes: an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation. — Health technology assessment (Winchester, England), 2026
187-OR: Randomized Clinical Trial of the IADPSG vs. Carpenter Coustan Criteria for Diagnosis of Gestational Diabetes Mellitus — Diabetes, 2020
Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A cross-sectional study. — Diabetes & metabolic syndrome, 2019
Gestational Diabetes in Somali Women: Neglected Risks for Maternal and Neonatal Health. — International journal of women's health, 2026

To what extent does maternal access to improved water and sanitation facilities mediate the relationship between maternal undernutrition and child developmental outcomes during the first 1,000 days?

Why this gap exists: While the retrieved papers confirm the individual importance of WASH access for child nutrition [0], maternal undernutrition for child development [5, 8], and the critical nature of the first 1,000 days [5], none of the provided abstracts directly analyze the specific mediating role of water and sanitation facilities in the relationship between maternal undernutrition and child developmental outcomes.

Sources

Household water, sanitation, and hygiene access and its impact on nutritional outcomes in children under five: evidence from Pakistan. — BMC public health, 2026
Early childhood development and stunting: Findings from the MAL‐ED birth cohort study in Bangladesh — Maternal and Child Nutrition, 2019
Policy and Structural Drivers of Malnutrition in Afghan Women: Evidence and Interventions. — International journal of women's health, 2026
COVID-19 pandemic and mitigation strategies: implications for maternal and child health and nutrition — American Journal of Clinical Nutrition, 2020
Maternal and child undernutrition 3: what works? Interventions for maternal and child undernutrition and survival — Child: Care, Health and Development, 2008
Nutrition as the Foundation of Human Capital: Pathways to Holistic Development. — Maternal & child nutrition, 2026
The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring. — The British journal of nutrition, 2017
Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study — The Lancet Global Health, 2020
Prevalence of undernutrition and its associated factors among pregnant women attending antenatal care service in public hospitals in Mogadishu, Somalia. — PloS one, 2026
Concurrent wasting and stunting among under‐five children in Niakhar, Senegal — Maternal & Child Nutrition, 2018

Publications

LDL‐C Estimation in Ghana: A Comparative Study of 13 Calculation Methods

BioMed Research International · 2026

Effect of Iron-Containing Micronutrient Powders on Growth and Malaria-Induced Anaemia Among Preschool Children in Ghana: A Cluster-Randomized, Double-Blind, Placebo-Controlled Trial

medRxiv · 2026

Macrophage immunometabolism dysregulation and inflammatory disorders

Biomedicine & Pharmacotherapy · 2025 · 19 citations

NF‑κB (p65) protein expression in head and neck tumors and its association with clinicopathological parameters

World Academy of Sciences Journal · 2025 · 3 citations

HIV-1 diagnostic, prognostic and ART-resistance detection potential of selected MiRNAs

BMC Infectious Diseases · 2025 · 1 citations

HLA-G 14 bp polymorphism: Implications and its associated risk to malaria severity among iron-fortified Ghanaian infants and young children

PLoS ONE · 2025 · corresponding author · 1 citations

Biomarkers in Colon Cancer Metastasis

2025

Expression patterns of plasma microRNAs in patients with cervical cancer from two teaching hospitals in Ghana

Journal of Cancer Research and Clinical Oncology · 2025

Iron deficiency anemia and its association with cognitive function among adolescents in the Ashanti Region - Ghana

BMC Public Health · 2024 · 14 citations

High prevalence of late presentation with advanced HIV disease and its predictors among newly diagnosed patients in Kumasi, Ghana

BMC Infectious Diseases · 2024 · 8 citations

Prognostic Significance of Nuclear Factor Kappa B (p65) among Breast Cancer Patients in Cape Coast Teaching Hospital

Medical Principles and Practice · 2024 · 4 citations

Dermatologic diseases in Africa: The profile of patients attending a tertiary hospital in the Ashanti Region of Ghana

Research Square · 2024 · 1 citations

Evaluation of Immune Characteristics and Factors Associated with Immune Response following Hepatitis B Vaccination among Ghanaian Adolescents

Advances in Virology · 2024 · 1 citations

Prior Knowledge and Antiretroviral Therapy Prophylaxis are Associated with Mother-To-Child Transmission of HIV/AIDS in Kumasi, Ghana

Research Square · 2024

Validity and reliability of the short-form adolescent health promotion scale among adolescents and young adults in Ghana: methodological study

Discover Public Health · 2024

Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups

BMC Nutrition · 2023 · 11 citations

Thyroid dysfunction and glycaemic control among Type 2 diabetes mellitus patients in Ghana: A comparative cross‐sectional study

Endocrinology Diabetes & Metabolism · 2023 · 8 citations

Prognostic Worth of Nrf2/BACH1/HO-1 Protein Expression in the Development of Breast Cancer

Medical Principles and Practice · 2023 · 6 citations

Comparison of Modified Manual Acid-Phenol Chloroform Method and Commercial RNA Extraction Kits for Resource Limited Laboratories

International Journal of Clinical Practice · 2023 · 6 citations

Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, Ghana

Health Science Reports · 2023 · 5 citations

Evaluating circulating soluble markers of endothelial dysfunction and risk factors associated with PE: A multicentre longitudinal case control study in northern Ghana

Heliyon · 2023 · 4 citations

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

The Scientific World JOURNAL · 2023 · 3 citations

Cytokine Profile and Common Uropathogens Among Diabetic Patients Visiting Cape Coast Teaching Hospital

SSRN Electronic Journal · 2023

Biomarkers in Colon Cancer Metastasis

2023

Profiling vitamin D, its mediators and proinflammatory cytokines in rheumatoid arthritis: A case–control study

Immunity Inflammation and Disease · 2022 · 13 citations

Factors associated with anti-retroviral therapy (ART) adherence among adult people living with HIV (PLWH): A 5-year retrospective multi-centre study in Kumasi, Ghana

Dialogues in Health · 2022 · 9 citations

Foeto-maternal complications associated with low birth weight: A prospective multicenter study in northern Ghana

PLoS ONE · 2022 · 8 citations

Evaluating immunohaematological profile among COVID-19 active infection and recovered patients in Ghana

PLoS ONE · 2022 · corresponding author · 7 citations

Assessing the role of eosinophil‐mediated immune response markers in detecting hookworm infection: A case‐control study in Kintampo, Ghana

Health Science Reports · 2022 · 5 citations

Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens

Health Science Reports · 2022 · corresponding author · 5 citations

Extracellular Vesicles as Biomarkers and Therapeutic Targets in Cancers

Physiology · 2022 · 3 citations

Treatment Failure, Knowledge, Attitude and Practices Related to Schistosomiasis and Soil-Transmitted Helminthic Infections among Basic School Pupils

Infectious diseases · 2022 · corresponding author · 3 citations

Assessing the variability and the role of inflammatory cytokines and monocyte chemoattractant protein-1 (MCP-1) in predicting stroke among hypertensives: A case-control study

Dialogues in Health · 2022 · 2 citations

Effect of Iron Fortification on Anaemia and risk of Malaria among Ghanaian Pre-School Children with Haemoglobinopathies and different ABO blood groups

Research Square · 2022

Effect of Iron Fortification on Anaemia and Risk of Malaria among Ghanaian Pre-School Children with Haemoglobinopathies and Different ABO Blood Groups

Research Square · 2022

Effect of Iron Fortification on Anaemia and risk of Malaria among Ghanaian Pre-School Children with Haemoglobinopathies and different ABO blood groups

Figshare · 2022

Effect of Iron Fortification on Anaemia and Risk of Malaria among Ghanaian Pre-School Children with Haemoglobinopathies and Different ABO Blood Groups

Research Square · 2022

Tissue inhibitor metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) best predicts the development of acute kidney injury

Heliyon · 2021 · 27 citations

Allanblackia floribunda Seed Extract Attenuates the Ethanol‐Induced Gastric Ulcer in Rats via the Inhibition of TNF‐α and INF‐γ Levels and Modulation in the Expression of Ki67 Protein

BioMed Research International · 2021 · 26 citations

A Review: Mechanism of Phyllanthus urinaria in Cancers—NF-κB, P13K/AKT, and MAPKs Signaling Activation

Evidence-based Complementary and Alternative Medicine · 2021 · 22 citations

Increased metformin dosage suppresses pro-inflammatory cytokine levels in systemic circulation and might contribute to its beneficial effects

Journal of Immunoassay and Immunochemistry · 2021 · 19 citations

Impact of iron fortification on anaemia and iron deficiency among pre-school children living in Rural Ghana

PLoS ONE · 2021 · 18 citations

In vitro and In vivo antimalarial activities of Avicennia africana P. Beauv. (Avicenniaceae) ethanolic leaf extract

Journal of Traditional and Complementary Medicine · 2021 · 15 citations

Vitamin D Deficiency Is Common in Ghana despite Abundance of Sunlight: A Multicentre Comparative Cross-Sectional Study

Journal of Nutrition and Metabolism · 2021 · 15 citations

Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens

BMC Infectious Diseases · 2021 · 13 citations

Profiling immuno-metabolic mediators of vitamin B12 deficiency among metformin-treated type 2 diabetic patients in Ghana

PLoS ONE · 2021 · 13 citations

Impact of IgG response to malaria-specific antigens and immunity against malaria in pre-school children in Ghana. A cluster randomized, placebo-controlled trial

PLoS ONE · 2021 · 5 citations

Cercariacidal activity of ripe and unripe lime oil extracts on Schistosoma mansoni

2021

Effect of IgG3 Hinge Region Length Polymorphisms on Iron Fortification among Rural Pre-School Ghanaian Children and Its Associated Risk to Malaria and Anaemia.

Food Science & Nutrition Research · 2021

Prognostic Worth of Epidermal Growth Factor Receptor (EGFR) in Patients with Head and Neck Tumors

Journal of Cancer Epidemiology · 2020 · 12 citations

Ameliorative Effect of Vernonia amygdalina Plant Extract on Heavy Metal-Induced Liver and Kidney Dysfunction in Rats

Advances in Pharmacological and Pharmaceutical Sciences · 2020 · 11 citations

Intracytoplasmic Expression of IL-6 and IL-17A in Circulating CD4+ T Cells Are Strongly Associated with and Predict Disease Activity in Rheumatoid Arthritis: A Case-Control Study in Ghana

International Journal of Rheumatology · 2020 · 10 citations

Prevalence and Risk Factors Associated With Preeclampsia, Low Birth Weight and Postpartum Hemorrhage in Northern Ghana

Research Square (Research Square) · 2020 · 3 citations

In-vitro Anti-cercarial activity of extracts and steroidal alkaloids from the stem bark of Holarrhena floribunda (G. Don) Dur. & Schinz

International Journal of Phytomedicine · 2020 · 2 citations

Intracytoplasmic expression of IL-6 and IL-17A in circulating CD4+ T cells are strongly associated with and predict disease activity in rheumatoid arthritis: A case-control study in Ghana

Research Square (Research Square) · 2020 · 2 citations

Profiling Immuno-Metabolic Mediators of Vitamin B12 Deficiency Among Metformin-Treated Type II Diabetes Patients in Ghana

Research Square · 2020 · 1 citations

Impact of Iron Fortification on Anaemia and Iron Deficiency among Pre-school Children Living in Rural Ghana

Research Square (Research Square) · 2020 · 1 citations

Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana

PLoS ONE · 2019 · 14 citations

Cytokine profiles of Necator americanus and Plasmodium falciparum co-infected patients in rural Ghana

Cytokine X · 2019 · corresponding author · 9 citations

Comparative Analysis of Haematological Parameters in Hookworm and Plasmodium falciparum Co-Infected Individuals in Kintampo North Municipality, Ghana

International Journal of TROPICAL DISEASE & Health · 2019 · 3 citations

In vitro Cercaricidal Activity of Fractions and Isolated Compounds of Erythrophleum ivorense (Fabaceae) Root Bark against Schistosoma haematobium

International Journal of TROPICAL DISEASE & Health · 2019 · 2 citations

Necator Americanus and Plasmodium Falciparum Co-Infection and Albendazole Treatment Outcome among Individuals in Rural Ghana

The Journal of Advances in Parasitology · 2019 · corresponding author · 1 citations

Inducible nitric oxide synthase 2 promoter polymorphism and malaria disease severity in children in Southern Ghana

PLoS ONE · 2018 · 10 citations

Epidemiology of Ocular Toxoplasmosis in Three Community Surveys in the Central Region of Ghana, West Africa

Ophthalmic Epidemiology · 2016 · 25 citations

Effect of pre-existing Schistosoma haematobium infection on Plasmodium berghei multiplications in imprinting control region mice

Asian Pacific Journal of Tropical Biomedicine · 2015 · corresponding author · 2 citations